Ibrutinib suppresses alloantibody responses in a mouse model of allosensitization [0.03%]
伊布替尼能够抑制致敏小鼠异种抗体的产生响应
Irene Kim,Gordon Wu,Ning-Ning Chai et al.
Irene Kim et al.
Background: Ibrutinib is a Bruton's tyrosine Kinase (BTK) antagonist that inhibits B cell receptor (BCR) signaling. Complete BTK deficiency is associated with absence of B-cells. Ibrutinb is currently approved by FDA for ...
Immune reconstitution with two different rabbit polyclonal anti-thymocytes globulins [0.03%]
两种不同兔多克隆抗胸腺细胞球蛋白的免疫重建
Jamal Bamoulid,Thomas Crepin,Emilie Gaiffe et al.
Jamal Bamoulid et al.
Broad T cell depletion by polyclonal anti-thymocyte globulins (ATG) has been used for many years as a part of immunosuppressive treatment in transplantation. Currently, two different ATG are used in clinical practice, Thymoglobulin and Graf...
Comparative Study
Transplant immunology. 2017 Dec:45:48-52. DOI:10.1016/j.trim.2017.09.002 2017
Immunoglobulin isotype switching of antibodies to vimentin is associated with development of transplant glomerulopathy following human renal transplantation [0.03%]
抗原?vimentin抗体的免疫球蛋白同种型转换与人类肾移植后的移植物系膜病相关性研究
Muthukumar Gunasekaran,Thin Thin Maw,Rowena Delos Santos et al.
Muthukumar Gunasekaran et al.
Background: Immune responses to tissue-restricted self-antigens are thought to play a role in chronic rejection after solid organ transplantation. De novo development of antibodies (Abs) to vimentin have been reported to ...
Migratory properties of ex vivo expanded regulatory T cells: Influence of all-trans retinoic acid and rapamycin [0.03%]
全反式视黄酸和雷帕霉素对体外扩增的调节性T细胞迁移特性的影响
J L Beermann,C T Thiesler,U Dringenberg et al.
J L Beermann et al.
Adoptively transferred regulatory T-cells represent a promising therapeutic approach for tolerance induction in autoimmunity and transplantation medicine. However, a major hurdle for clinical application is the manufacturing of sufficient T...
B-cell activating factor BAFF reflects patients' immunological risk profile after kidney transplantation [0.03%]
B细胞激活因子BAFF可反映肾移植受者的免疫风险特征
A Schuster,B Jung,J Hofbauer et al.
A Schuster et al.
The B-cell activating factor BAFF plays an important role in the development and maturation of B-lymphocytes, which can contribute to the generation of donor-specific antibodies and thus may influence graft function and graft survival. Inco...
Comparative Study
Transplant immunology. 2017 Dec:45:35-41. DOI:10.1016/j.trim.2017.08.006 2017
T cell costimulation blockade promotes transplantation tolerance in combination with sirolimus and post-transplantation cyclophosphamide for haploidentical transplantation in children with severe aplastic anemia [0.03%]
T细胞共刺激阻断联合西罗莫司及移植后环磷酰胺用于儿童再生障碍性贫血半匹配移植中的应用研究
Sarita Rani Jaiswal,Prakash Bhakuni,Shamsuz Zaman et al.
Sarita Rani Jaiswal et al.
We conducted a pilot study employing extended T cell costimulation blockade (COSBL) with Abatacept along with sirolimus and post-transplantation cyclophosphamide (PTCy) in 10 patients (median age 12) with severe aplastic anemia (SAA). Nine ...
Clinical Trial
Transplant immunology. 2017 Aug:43-44:54-59. DOI:10.1016/j.trim.2017.07.004 2017
Pre-transplant infusion of donor-derived dendritic cells maintained at the immature stage by sinomenine increases splenic Foxp3+ Tregs in recipient rats after renal allotransplantation [0.03%]
肾移植前输入由青藤碱维持在未成熟阶段的供者树突状细胞增加受体大鼠移植后脾脏中Foxp3+Treg细胞的比例
Lian Li,Zhigang Luo,Zhe Song et al.
Lian Li et al.
Objective: The immunosuppressive mechanism of sinomenine in organ allotransplantation was investigated, especially its effect of blocking dendritic cell (DC) maturation, which might influence the frequency of regulatory T...
NKT cells are important mediators of hepatic ischemia-reperfusion injury [0.03%]
NKT细胞是肝缺血再灌注损伤的重要介导因素
James A Richards,Stephen J Wigmore,Stephen M Anderton et al.
James A Richards et al.
Introduction: IRI results from the interruption then reinstatement of an organ's blood supply, and this poses a significant problem in liver transplantation and resectional surgery. In this paper, we explore the role T ce...
Deleterious impact of C3d-binding donor-specific anti-HLA antibodies after pediatric liver transplantation [0.03%]
儿童肝脏移植后C3d结合的供者特异性抗HLA抗体的不利影响
Eduardo Couchonnal,Christine Rivet,Stéphanie Ducreux et al.
Eduardo Couchonnal et al.
Background: The prevalence and clinical impact of anti-HLA donor-specific antibodies (DSA) after liver transplantation (LT) have not been extensively studied, especially in pediatric population. ...
Adipose-derived mesenchymal stem cells promote liver regeneration and suppress rejection in small-for-size liver allograft [0.03%]
脂肪来源的间充质干细胞促进小体积异体肝移植的肝脏再生和抑制排斥反应
Wei Gao,Luzhou Zhang,Yanyan Zhang et al.
Wei Gao et al.
Adipose-derived mesenchymal stem cells (ADSCs) possess a liver regeneration capacity and immunosuppressive activity and hold promise in autologous cell-based technology. This study aimed to determine whether autologous ADSCs can improve out...