Time is life: EpAssistant - a new tool for the automatic identification of anti-HLA antibody epitope specificity in transplant programs [0.03%]
时间就是生命：EpAssistant——移植项目中识别抗HLA抗体表位特异性的新工具
Keylla S U Aita,Semiramis J H Monte,Adalberto S Silva et al.
Keylla S U Aita et al.
Background and objectives: This work aims to present the expert system EpAssistant, a platform algorithm designed to accurately and automatically identify the EPLETS specificities of anti-HLA (Human Leukocyte Antigen) ant...
Administration of donor splenocytes via the respiratory tract generates CD8α+ regulatory dendritic cells and induces hyporesponsiveness to fully allogeneic cardiac grafts [0.03%]
经呼吸道给入供者脾细胞可生成CD8α+调节性树突状细胞并使受者对同种异体心脏移植物产生免疫无能
Daiki Iwami,Osamu Aramaki,Nobuo Shinohara et al.
Daiki Iwami et al.
Background: We previously showed that pretreatment with intratracheal delivery (ITD) of alloantigen induced prolonged cardiac allograft survival and generated regulatory T cells (Tregs) in mice. In this study, we examined...
Tacrolimus has immunosuppressive effects on heavy/light chain pairs and free light chains in patients after heart transplantation: A relationship with infection [0.03%]
他克莫司对心脏移植患者重链/轻链对和游离轻链的免疫抑制效应及其与感染的关系
Petra Lavríková,Peter Sečník,Zdenek Kubíček et al.
Petra Lavríková et al.
The aim of the study was to investigate the relationship between tacrolimus (TAC) immunosuppressive treatment and serum concentrations of immunoglobulin heavy/light chain pairs (sHLC) and free light chains (sFLC) in patients after heart tra...
The clinical significance of epitope mismatch load in kidney transplantation: A multicentre study [0.03%]
肾移植中抗原表位不匹配负担的临床意义：多中心研究
Liesbeth Daniëls,Maarten Naesens,Jean-Louis Bosmans et al.
Liesbeth Daniëls et al.
Since the advent of kidney transplantation a key strategy for maximising graft survival by avoiding allorecognition has been to minimise HLA mismatching between donor and recipient. As HLA antibodies are now recognised as being specific for...
Multicenter Study
Transplant immunology. 2018 Oct:50:55-59. DOI:10.1016/j.trim.2018.06.006 2018
Characterization of monocyte subtypes regarding their phenotype and development in the context of graft-versus-host disease [0.03%]
供体淋巴细胞输注后移植物抗宿主病背景下单核细胞亚群的表型及发育特征分析
Katharina Reinhardt-Heller,Insa Hirschberg,Thomas Vogl et al.
Katharina Reinhardt-Heller et al.
Graft-versus-host disease (GvHD) is a major cause of morbidity and mortality after allogeneic hematopoietic cell transplantation (HCT). In this study, monocyte subtypes were characterized regarding cytokine expression pattern and developmen...
Transplantation preferentially induces a KLRG-1lo CD127hi differentiation program in antigen-specific CD8+ T cells [0.03%]
移植通过优先诱导抗原特异性CD8⁺T细胞向KLRG-1lowCD127hi方向的功能分化来增强记忆性反应
Alana M Bozeman,Sonia J Laurie,Divya Haridas et al.
Alana M Bozeman et al.
Models of infection have shaped our understanding of programmed memory T cell differentiation, yet whether these models apply to memory programming in the context of transplantation has yet to be defined. Previous work has identified differ...
Comparative Study
Transplant immunology. 2018 Oct:50:34-42. DOI:10.1016/j.trim.2018.06.003 2018
Value of C3d assay and IgG subclass in the prediction of the flow cytometry cross-match result for renal transplantation [0.03%]
补体C3d检测和IgG亚类检测在肾移植流式交配试验中的价值分析
Alan G Contreras,Aurora Casillas-Abundis,Josefina Alberú et al.
Alan G Contreras et al.
The aim of this study is to compare the association and the predictive capacity of DSA MFI, complement fixing capacity (C3d assay) and IgG subclasses determination in the prediction of FCxM result. ...
Observational Study
Transplant immunology. 2018 Oct:50:8-14. DOI:10.1016/j.trim.2018.05.002 2018
Dual antibody induction and de novo use of everolimus enable low-dose tacrolimus with early corticosteroid withdrawal in simultaneous pancreas-kidney transplantation [0.03%]
新型免疫抑制方案在胰肾联合移植中应用的前瞻性研究
Jun Li,Martina Koch,Kathrin Kramer et al.
Jun Li et al.
Background: To be an optimal immunosuppressive regimen after simultaneous pancreas kidney transplantation (SPK), low dose calcineurin inhibitor and early withdrawal of corticosteroids are desired. ...
Screening RhoA/ROCK inhibitors for the ability to prevent chronic rejection of mouse cardiac allografts [0.03%]
筛选RhoA/ROCK抑制剂预防小鼠心脏异体移植慢性排斥反应的能力
Wei Chen,Song Chen,Wenhao Chen et al.
Wei Chen et al.
Background: Chronic rejection of transplanted organs is a major obstacle in organ transplantation. The main symptoms of chronic rejection are vessel occlusion and tissue fibrosis. Macrophages play a crucial role in chroni...
Effect of long-term immunosuppressive therapy on native rat liver morphology and hepatocyte- apoptosis [0.03%]
长期免疫抑制治疗对大鼠肝组织形态及肝细胞凋亡的影响研究
Aleksandra Wilk,Dagmara Szypulska-Koziarska,Karolina Kędzierska-Kapuza et al.
Aleksandra Wilk et al.
A negative result of therapy based on immunosuppressive drugs is its leading to pathological alterations in the organ, including liver. Use of immunosuppressive medication may also lead to organized and genetically controlled cell death - a...