PD-1 inhibitor use for skin malignancies in patients with solid organ and bone marrow transplants: Graft rejection, treatment responses, and survival [0.03%]
器官移植及骨髓移植患者中使用PD-1抑制剂治疗皮肤恶性肿瘤：移植物排斥、治疗反应和生存期
Lily M Parker,Kate E Beekman,Meredith E Thomley et al.
Lily M Parker et al.
Importance: Solid organ transplant recipients face a markedly increased risk of aggressive skin cancers. Programmed cell death protein-1 (PD-1) inhibitors have significantly improved outcomes for advanced melanoma, squamo...
Macrae Kozody,Roberta Buccilli,Giovanni Faddoul et al.
Macrae Kozody et al.
Social determinants of health, bias and genetic predisposition contribute to racial inequities in chronic kidney disease (CKD)and kidney transplant (KTX) allocation. Recognizing and addressing these complex factors leads to improvement in o...
ELAVL1-stabilized USP22 promotes diabetic nephropathy progression via mediating podocyte injury and death by triggering ACSL4 deubiquitination [0.03%]
通过触发ACSL4去泛素化介导足细胞损伤和死亡促进糖尿病肾病进展的ELAVL1稳定USP22的作用
Xin Wang,Wei Wang,MengYing Han et al.
Xin Wang et al.
Background: Diabetic nephropathy (DN) represents approximately 50 % of all chronic kidney disease cases. Given the established involvement of USP22 in DN progression, this study investigated its underlying regulatory mech...
Juhi R Patel,John Dark,Daniel Harvey et al.
Juhi R Patel et al.
Background: Inflammatory injury in organ donors, particularly after brain death and during ischemia-reperfusion, contributes to graft dysfunction, rejection, and reduced survival. Statins, beyond their lipid-lowering role...
Pre-transplant compatibility testing: Transition from CDCXM to flow cytometry in India [0.03%]
移植前兼容性检验：印度从CDCXM向流式细胞术过渡
Kashyap Shubham,Junior Scientist,K Tiwari Kumar Aseem et al.
Kashyap Shubham et al.
Over 60 % of kidney transplant candidates are non-sensitised while remaining 40 % are sensitised because of previous exposure to human alloantigens during previous transplants, blood transfusions, and pregnancy in women. Pre-transplant comp...
Fxyd5 downregulation protects the heart from ischemia/reperfusion injury by suppressing myocardial inflammation [0.03%]
FXYD5通过抑制心肌炎症保护心脏免受缺血/再灌注损伤
Lei Zhang,Junjie Xu,Fujiang Cui et al.
Lei Zhang et al.
Background: Myocardial ischemia/reperfusion (I/R) injury is a common cause of death. FXYD domain-containing ion transport regulator-5 (Fxyd5) is a type I membrane protein that plays a significant role in mediating cellula...
Case report: Hyperacute rejection of living relative kidney transplantation caused by colony-stimulating factor 2 antibodies [0.03%]
个例报告：集落刺激因子 2 抗体导致的亲属活体肾移植超急性排斥反应
Qixuan Li,Zhaoying Pang,Meng Yang et al.
Qixuan Li et al.
Kidney transplantation (KT) stands as a highly effective, life-saving intervention for patients with end-stage renal disease, offering substantial improvements in both quality of life and long-term survival. However, one of the most critica...
Case Reports
Transplant immunology. 2025 Sep 2:102285. DOI:10.1016/j.trim.2025.102285 2025
Fatemeh Moosaie,Shiva Abedinzadeh,Sepide Javankiani et al.
Fatemeh Moosaie et al.
Background and aim: Lung transplantation (LTx) is increasingly performed worldwide, yet post-transplant survival remains lower than for other solid organs. Diabetes mellitus (DM) is common among LTx recipients and impacts...
Myth or reality: Graft versus host disease after autologous hematopoietic cell transplantation, a multicentre experience [0.03%]
自体造血细胞移植后移植物抗宿主病的多中心经验：事实还是传说
Süreyya Yiğit Kaya,Leylagül Kaynar,Yaşa Gül Mutlu et al.
Süreyya Yiğit Kaya et al.
Acute graft-versus-host disease (aGvHD) is a rare but clinically significant complication of autologous hematopoietic cell transplantation. The aim of this retrospective multicenter study was to evaluate the clinical features, outcomes and ...
IL-6 amplifies corneal transplant alloimmunity by inducing dysfunctional IFN-γ- secreting Treg through the VEGFA-VEGFR1 axis [0.03%]
通过血管内皮生长因子A-Ⅰ型血管内皮生长因子受体轴诱导分泌干扰素-γ功能障碍的调节性T细胞放大白细胞介素6角膜移植排斥反应
Seokjoo Lee,Akitomo Narimatsu,Neda Heydarian et al.
Seokjoo Lee et al.
Background: Corneal allografts generally exhibit high acceptance due to the immune-privileged ocular microenvironment. Regulatory T cells (Treg) promote graft tolerance; however, in a vascularized milieu, they may acquire...