Khalid Al-Nedawi,Sandor Haas-Neill,Azim Gangji et al.
Khalid Al-Nedawi et al.
Renal transplantation is an effective therapy with improved long-term outcomes compared with other therapies for end stage renal disease. Present methods for evaluating kidney allograft function, such as serum creatinine or allograft biopsy...
Impact of alemtuzumab pharmacokinetics on T-cell dynamics, graft-versus-host disease and viral reactivation in patients receiving allogeneic stem cell transplantation with an alemtuzumab-based T-cell-depleted graft [0.03%]
抗CD52单克隆抗体 Alemtuzumab 的药代动力学对allo-HSCT患者移植物抗宿主病及病毒再活化的影响：T细胞动力学的中介作用
Floris C Loeff,Esther H M van Egmond,Dirk J A R Moes et al.
Floris C Loeff et al.
Administration of alemtuzumab (targeting the CD52 antigen) to the patient (in-vivo) or to the graft (in-vitro) before allogeneic stem cell transplantation (alloSCT) decreases the incidence of graft-versus-host disease (GvHD). Effectiveness ...
Elda Righi,Federico Ivaldi,Alessandro La Rosa et al.
Elda Righi et al.
Background: Scarce data are available about immune cell frequencies in HIV-positive recipients of liver transplant. Alterations in immune subsets can lead to persistent immune activation and disease progression or reduced...
Switching renal transplant recipients to belatacept therapy: results of a real-life gradual conversion protocol [0.03%]
BELATACEPT转换治疗肾脏移植受者：逐步转换方案的实际情况结果分析
Paolo Malvezzi,Clara Fischman,Guillaume Rigault et al.
Paolo Malvezzi et al.
Conversion to belatacept immunosuppression is a therapeutic option for renal-transplant recipients with calcineurin inhibitors (CNI) toxicity, but it associates with high risk of acute rejection. Gradual conversion and serial immune monitor...
Analysis of genetic and clinical risk factors of post-transplant thrombocytopenia in kidney allograft recipients [0.03%]
肾移植受者术后血小板减少的遗传及临床风险因素分析
Kyung Hee Choi,Youngil Chang,Tariq Shah et al.
Kyung Hee Choi et al.
Background: Hematological abnormalities after transplantation are complications that may arise after renal transplantation, of which thrombocytopenia is associated with increased risk of bleeding and other complications. ...
Adipose tissue-derived mesenchymal stem cells ameliorate bone marrow aplasia related with graft-versus-host disease in experimental murine models [0.03%]
脂肪来源的间充质干细胞改善小鼠移植物抗宿主病相关的骨髓细胞减少症
Yukiko Nishi,Akikazu Murakami,Yuko Murayama et al.
Yukiko Nishi et al.
Graft-versus-host disease (GVHD) constitutes the most frequent complications after the allogeneic hematopoietic stem cell transplantation for a variety of hematological malignancies. In the present study, we explored the prophylactic potent...
Recurrent acute cellular rejection graded ISHLT 1R early after heart transplantation negatively affects long-term outcomes: The prognostic significance of 1990 ISHLT grades 1B and 2 [0.03%]
心脏移植后早期ISHLT分级为1级的复发性急性细胞排斥反应影响长期预后：1990年ISHLT 1B和2级分级的预后意义
Yael Peled,Jacob Lavee,Eilon Ram et al.
Yael Peled et al.
Purpose: We investigated the implications of early recurrent 1R rejections for long-term outcomes after heart transplantation (HT) and evaluated the prognostic significance of 1990 ISHLT grading 1B/2 versus 1A. ...
Clinical Trial
Transplant immunology. 2019 Aug:55:101204. DOI:10.1016/j.trim.2019.03.003 2019
Endowing human CD8 T cells with a veto-like recognition capacity via the electroporation of MHC-I/CD3ζ mRNA [0.03%]
电转递呈人MHC-I/CD3ζ mRNA赋予CD8+T细胞类似拒斥作用的识别功能
Orly Weissberg,Gideon Gross
Orly Weissberg
Graft-versus-host disease (GVHD) and transplant rejection as a result of host-versus-graft (HVG) response have remained two major complications of allogeneic hematopoietic stem cell transplantation (allo-HSCT). When donors are partially HLA...
Salvianolic acid B ameliorates liver injury in a murine aGvHD model by decreasing inflammatory responses via upregulation of HO-1 [0.03%]
salvianolic酸B通过上调HO-1降低炎症反应以改善小鼠aGVHD肝损伤
Jing Zhao,Xing-Chen Yang,Masayuki Fujino et al.
Jing Zhao et al.
Acute graft-versus-host disease (aGvHD) remains lethal, even after allogeneic hematopoietic stem cell transplantation. Inflammatory responses play an important role in aGvHD. Salvianolic acid B (Sal B) has been widely reported to have a maj...
Increased CD16 expression on NK cells is indicative of antibody-dependent cell-mediated cytotoxicity in chronic-active antibody-mediated rejection [0.03%]
慢性活动性抗体介导的排斥反应中NK细胞上CD16表达水平升高提示抗体依赖性细胞毒性作用
Kasia A Sablik,Nicolle H R Litjens,Mariska Klepper et al.
Kasia A Sablik et al.
Chronic-active antibody mediated rejection (c-aABMR) contributes significantly to late renal allograft failure. The antibodies directed against donor-derived antigens, e.g. anti-HLA antibodies, cause inflammation at the level of the microva...