Pre-existing self-reactive IgA antibodies associated with primary graft dysfunction after lung transplantation [0.03%]
术前存在的自身反应性IgA抗体与肺移植后的原发性移植物失功能相关性研究
Vaidehi Kaza,Chengsong Zhu,Leying Feng et al.
Vaidehi Kaza et al.
Background: Primary graft Dysfunction (PGD) results in significant mortality and morbidity after lung transplantation (LT). The objective of this study was to evaluate if pre-existing antibodies to self-antigens in sera o...
Combined treatment with vitamin D3 and antibody agents suppresses secondary heart transplant rejection in the early postoperative period [0.03%]
维生素D3和抗体药物联合治疗可抑制二次心脏移植排异反应
Baiyi Xie,Yunhan Ma,Yanfeng Xi et al.
Baiyi Xie et al.
Background: Accelerated transplant rejection mediated by donor reactive memory T cells is another barrier to the induction of graft tolerance. The aim of this study was to investigate the immunosuppressing effects of vita...
Receptor activator of the NFκB ligand system protects renal function during experimental renal ischemia-reperfusion in mice [0.03%]
核因子kB配体保护肾在实验性肾缺血再灌注损伤中的作用
Yuki Nakayama,Naohito Isoyama,Takeshi Yamamoto et al.
Yuki Nakayama et al.
Renal ischemia-reperfusion (I/R) injury is closely associated with delayed graft function and poor long-term graft survival following transplantation. Various pathophysiologies can cause the deterioration of renal function; however, the imm...
Prospective validation of the L-index reflecting both the intensity and duration of lymphopenia and its detailed evaluation using a lymphocyte subset analysis after allogeneic hematopoietic stem cell transplantation [0.03%]
L指数的前瞻性验证：其不仅反映淋巴细胞减少的强度也反映持续时间，并使用allo-HSCT后的亚型分析进行详细评估
Shun-Ichi Kimura,Miki Sato,Yukiko Misaki et al.
Shun-Ichi Kimura et al.
We prospectively validated the previously reported L-index, which reflects both the intensity and duration of lymphopenia, and further evaluated it using a lymphocyte subset analysis after allogeneic hematopoietic stem cell transplantation ...
An in vitro model of antibody-mediated injury to glomerular endothelial cells: Upregulation of MHC class II and adhesion molecules [0.03%]
一种抗体介导的损伤肾小球内皮细胞的体外模型：MHCⅡ类分子和粘附分子的上调表达
Nancy A Wilson,James Dylewski,Kenna R Degner et al.
Nancy A Wilson et al.
Chronic active antibody-mediated rejection is a major cause of allograft failure in kidney transplantation. Microvascular inflammation and transplant glomerulopathy are defining pathologic features of chronic active antibody-mediated reject...
TLR2 and NODs1 and 2 cooperate in inflammatory responses associated with renal ischemia reperfusion injury [0.03%]
TLR2和NOD1/2在肾脏缺血再灌注损伤相关炎症反应中合作作用
Sashi G Kasimsetty,Alana Hawkes,Kayvan Barekatain et al.
Sashi G Kasimsetty et al.
Pattern recognition receptors (PRRs) are potent triggers of tissue injury following renal ischemia/reperfusion injury (IRI). Specific PRRs, such as the toll-like receptor 2 (TLR2) and the nucleotide-binding oligomerization domain-like recep...
Identification of the immunological profile in rejection-free heart transplantation [0.03%]
无排斥反应心脏移植患者的免疫谱特征识别
Kristin Klaeske,Sven Lehmann,Petra Büttner et al.
Kristin Klaeske et al.
Background: Tolerance induction following organ transplantation can be achieved by adoptive cell transfer of regulatory T-cells (Tregs) or dendritic cells (DCs). However, the target immunological profile is unknown. The p...
Impact of immunosuppressive therapy on brain derived cytokines after liver transplantation [0.03%]
肝移植后免疫抑制治疗对脑源性细胞因子的影响
Meike Dirks,Henning Pflugrad,Anita B Tryc et al.
Meike Dirks et al.
Background: While acute neurotoxic side effects of calcineurin inhibitors (CNI) are well-known, data upon long-term effects on brain structure and function are sparse. We hypothesize that long-term CNI therapy affects the...
Effects of recombinant thrombomodulin on long-term prognosis after allogeneic hematopoietic stem cell transplantation [0.03%]
重组血栓调节蛋白对同种异体造血干细胞移植后长期预后的影响
Shosaku Nomura,Akiko Konishi,Yukie Tsubokura et al.
Shosaku Nomura et al.
We investigated the effects of early recombinant thrombomodulin (rTM) treatment on long-term prognosis after hematopoietic stem cell transplantation (HSCT). Subjects included 300 patients who underwent allogeneic HSCT (131 in the rTM(+) gro...
Strategies to achieve immune tolerance in allogeneic solid organ transplantation [0.03%]
同种异体器官移植中实现免疫耐受策略
Sen Zeng,Zhenyang Xiao,Qun Wang et al.
Sen Zeng et al.
Organ transplantation is an effective way to treat many end-stage diseases. In order to overcome post-transplant rejection, immunosuppressive agents have been widely used, but the long-term survival of transplanted organs still has not been...