High expression of granzyme B in conventional CD4+ T cells is associated with increased relapses after allogeneic stem cells transplantation in patients with hematological malignancies [0.03%]
高表达颗粒酶B的常规CD4+T细胞与血液系统恶性肿瘤患者异基因造血干细胞移植后复发增多相关
Mikhail Drokov,Yulia Davydova,Natalia Popova et al.
Mikhail Drokov et al.
Granzyme B is known to be a serine protease contained in granules of cytotoxic T cells. We have previously reported an influence of granzyme B expression in T regulatory cells (Tregs) on the risk of acute graft versus host disease (GVHD) on...
Gastric submucosal alleviated pro-inflammation cytokines mediated initial dysfunction of islets allografts [0.03%]
胃亚黏膜减轻异体胰岛移植早期炎症反应及功能障碍
Zhuzeng Yin,Jiaxin Li,Yang Zheng et al.
Zhuzeng Yin et al.
Background: The liver and renal capsule are the most common site for experimental pancreatic islet transplantation, but it is not optimal. Gastric submucosa space may be an ideal site for islet transplantation; however, w...
Reduced CD4+ CD25++ CD45RA- Foxp3hi activated regulatory T cells and its association with acute rejection in patients with kidney transplantation [0.03%]
肾脏移植患者中调节性T细胞亚群的改变及其与急性排斥反应的相关性研究
Mohammad Mirzakhani,Mehdi Shahbazi,Roghayeh Akbari et al.
Mohammad Mirzakhani et al.
Background: It was found that regulatory T cells (Tregs) importantly affect the maintenance of the kidney graft. However, Tregs are a heterogeneous population with less to more suppressive activity. The aim of this study ...
Dialysis therapy is associated with peripheral marginal zone B-cell augmentation [0.03%]
透析与外周边缘区B细胞增多相关
Lucia Stranavova,Petra Hruba,Janka Slatinska et al.
Lucia Stranavova et al.
Chronic kidney disease stage 5 (CKD5) dialysis patients who stay long term in uremic environment often exhibit several, poorly defined, immune impairments. In this study, we assessed peripheral virus-specific effector/memory cells and subpo...
Acute cellular rejection in small-bowel transplantation impairs NCR+ innate lymphoid cell subpopulation 3/interleukin 22 axis [0.03%]
小肠移植急性细胞排斥通过NCR+先天淋巴样细胞亚群3/白介素22轴损害肠道功能
Melisa Pucci Molineris,Virginia González Polo,Carolina Rumbo et al.
Melisa Pucci Molineris et al.
Acute cellular rejection (ACR) remains as one of the main causes of graft loss and death in intestinal transplant (ITx) patients. ACR promotes intestinal injury, disruption of the mucosal barrier, bacterial translocation, and organ dysfunct...
The role of HLA-DP mismatches and donor specific HLA-DP antibodies in kidney transplantation: a case series [0.03%]
HLA-DP不匹配和供者特异性抗-HLA-DP抗体在肾移植中的作用：一系列病例的研究
Liesbeth Daniëls,Frans H J Claas,Cynthia S M Kramer et al.
Liesbeth Daniëls et al.
Background: The impact of HLA-DP mismatches on renal allograft outcome is still poorly understood and is suggested to be less than that of the other HLA loci. The common association of HLA-DP donor-specific antibodies (DS...
Multicenter Study
Transplant immunology. 2021 Apr:65:101287. DOI:10.1016/j.trim.2020.101287 2021
A potential role of neutrophil extracellular traps (NETs) in kidney acute antibody mediated rejection [0.03%]
中性粒细胞胞外陷阱(NETs)在急性抗体介导的肾排斥反应中的潜在作用
Jiram Torres-Ruiz,Roxana Villca-Gonzales,Diana Gómez-Martín et al.
Jiram Torres-Ruiz et al.
Background: The aim of this study was to evaluate neutrophil extracellular traps (NETs) in kidney transplant recipients (KTR) and their potential involvement in acute antibody-mediated rejection (AAMR). ...
Serum dilutions as a predictive biomarker for peri-operative desensitization: An exploratory approach to transplanting sensitized heart candidates [0.03%]
血清稀释液作为术前脱敏的预测生物标志物：移植供体心脏受者的探索性方法
Olga A Timofeeva,Rene Alvarez,Justin Pelberg et al.
Olga A Timofeeva et al.
Antibody-mediated rejection (AMR) of cardiac allografts mediated by anti-HLA Donor Specific Antibodies (DSA) is one of the major barriers to successful transplantation for the treatment of end-stage heart failure. Therapeutic plasma exchang...
Epithelial-mesenchymal transition and membrane microparticles: Potential implications for bronchiolitis obliterans syndrome after lung transplantation [0.03%]
上皮间质转化和微囊泡：对肺移植后闭塞性细支气管炎综合征的潜在影响
Benjamin Renaud-Picard,Kevin Vallière,Justine Toussaint et al.
Benjamin Renaud-Picard et al.
Long term survival post lung transplantation (LTx) is limited by the occurrence of bronchiolitis obliterans syndrome (BOS). One mechanism involved is the epithelial-mesenchymal transition (EMT). Membrane microparticles (MPs) are known to be...
Exploring predicted indirectly recognizable HLA epitopes (PIRCHE-II) in liver transplant recipients on calcineurin inhibitor-free maintenance immunosuppression. A retrospective single center study [0.03%]
他克莫司减停后肝移植受者PIRCHE-II表位的回顾性研究
Magdalena Meszaros,Matthias Niemann,José Ursic-Bedoya et al.
Magdalena Meszaros et al.
The PIRCHE (Predicted Indirectly ReCognizable HLA Epitopes) score is an HLA epitope matching algorithm. PIRCHE algorithm estimates the level of presence of T-cell epitopes in mismatched HLA. The PIRCHE-II numbers associate with de novo dono...