Research on gene editing and immunosuppressants in kidney xenotransplantation [0.03%]
基因编辑和免疫抑制剂在肾脏异种移植中的研究
JiaJiao Luo,CongWen Bian,Min Liu et al.
JiaJiao Luo et al.
Gene-edited pig organ transplantation can solve the serious shortage of human donor organs. Currently, xenotransplantation is rapidly developing and has made significant breakthroughs. The use of GTKO (Gal knockout) pigs is an important ste...
Cuproptosis gene characterizes the immune microenvironment of diabetic nephropathy [0.03%]
铜死亡基因表征糖尿病肾病的免疫微环境
Liping Guo,Fei Liu,Hui Li et al.
Liping Guo et al.
Background: The cuproptosis is an intracellular copper (Cu) accumulation triggering the aggregation of mitochondrial lipoylated proteins and destabilization of iron‑sulfur (FeS) cluster proteins, leading to cell death. T...
Novel CD62L depleted donor lymphocyte infusion with T-cell receptor alpha-beta depleted haploidentical hematopoietic stem cell transplantation in children [0.03%]
CD62L耗竭的供者淋巴细胞输注联合T细胞受体α-β链耗竭的半相合造血干细胞移植治疗儿童患者
Daniel Ka Leung Cheuk,Pamela Pui Wah Lee,Wilson Yau Ki Chan et al.
Daniel Ka Leung Cheuk et al.
Ex-vivo depletion of donor CD45RA+ naïve T-cells can reduce graft-versus-host-disease (GVHD) in haploidentical hematopoietic stem cell transplantation (HSCT) while providing memory T-cells to reduce infections. CD62L is another marker of n...
Lianying Cheng,Xiaofeng Rong
Lianying Cheng
Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disorder primarily distinguished by synovial inflammation, which, as the disease evolves, can lead to bone erosion and destruction. Consequently, the pivotal strategy in preventing...
Impact of tacrolimus time in therapeutic range (TTR) on early post transplantation outcomes [0.03%]
他克莫司有效范围内时间占比与移植术后早期预后之间的关系
Mariano Berro,Silvina Odstrcil,Milagros Frassa et al.
Mariano Berro et al.
Tacrolimus is a backbone for immunosuppression after allogeneic stem cell transplantation (AlloSCT). There is no sufficient kinetic data demonstrating the consistency of maintaining therapeutic levels. Herein, we measured the kinetic of the...
CMV management of patients with leukopenia after CMV high-risk kidney transplantation [0.03%]
肾移植后出现CMV高风险白细胞减少患者的管理
Amina Abu-Omar,Janine Mihm,Saskia Bronder et al.
Amina Abu-Omar et al.
Background: For CMV high-risk constellations, guidelines recommend 3-6 months of prophylaxis with valganciclovir (VGCV). Management in preventing CMV primary infection in patients developing VGCV-associated leukopenia rem...
Effective management of primary central nervous system posttransplant lymphoproliferative disorder in a kidney transplant recipient using surgery and rituximab, along with a literature review [0.03%]
有效联合手术和利妥昔单抗治疗1例肾移植受者的中枢神经系统PTLD及文献回顾
Guangjun Liu,Rending Wang,Jianyong Wu et al.
Guangjun Liu et al.
Background: Primary central nervous system post-transplant lymphoproliferative disorder (PCNS-PTLD) is a rare but severe complication following solid organ transplantation (SOT). Currently, treatment regimens still lack c...
Study of human leukocyte antigen (HLA) allele and haplotype frequency using next generation sequencing (NGS) platform: Single-centre study of over 500 individuals in India! [0.03%]
基于下一代测序平台的人类白细胞抗原（HLA）等位基因和单倍体型频率的研究——来自印度一个中心的超过500人的研究！
Mehra Simmi,K Tiwari Aseem,Chauhan Rajni et al.
Mehra Simmi et al.
Background: The huge diversity of Human Leukocyte Antigen (HLA) system is well-known to be associated with various diseases, anthropology, population genetics, and transplantation. The frequencies of HLA alleles in differ...
Trametinib alleviates lipopolysaccharide-induced acute kidney injury by inhibiting macrophage polarization through the PI3K/Akt pathway [0.03%]
trametinib通过PI3K/Akt信号通路抑制巨噬细胞极化缓解脂多糖诱导的急性肾损伤
Yingqi Zeng,Wenjia Yuan,Chen Feng et al.
Yingqi Zeng et al.
Background: Sepsis-induced acute kidney injury (AKI) is a severe condition characterized by dysregulation of pro- and anti-inflammatory responses. Targeting macrophage polarization between pro-inflammatory M1 and anti-inf...
Hsp90 and HIF-1α regulate mitophagy by promoting BNIP3 expression in renal ischemia-reperfusion injury [0.03%]
Hsp90和HIF-1α通过促进BNIP3表达调节线粒体自噬在肾缺血再灌注损伤中的作用
Qi Dong,Xia Li,Ke Cheng
Qi Dong
Background: Ischemia-reperfusion injury (IRI) is a major cause of acute kidney injury (AKI). Studies have shown that mitochondrial damage is involved in the pathogenesis of AKI, and that inhibition of Hsp90 expression can...