Exploration of causal relationship between transplant rejection and immune cells: A two-sample Mendelian randomization study [0.03%]
移植排斥与免疫细胞间因果关系的两样本孟德尔随机化研究
Fei Xue,Xuanpeng Wu,Ming Ni et al.
Fei Xue et al.
Post-transplant rejection is a serious problem for patients undergoing organ transplantation. It is currently believed that immune-related factors are the main causes of transplant rejection, but the roles of many immune cell phenotypes are...
Impacts of donor-specific anti-HLA antibodies on post-transplant clinical outcomes in hematopoietic stem cell transplantation: A systematic review and meta-analysis [0.03%]
造血干细胞移植中供者特异性抗HLA抗体对移植后临床结局影响的系统评价和Meta分析
Muchen Liu,Zhongyu Kang,Huan Zhang
Muchen Liu
Background: Donor-specific antibodies (DSAs) are a major risk factor for adverse clinical outcomes in hematopoietic stem cell transplantation (HSCT). However, their clinical relevance remains controversial and unclear. Th...
Research progress and current status of gene-edited-pig to non-human primate kidney xenotransplantation drug application [0.03%]
基因编辑猪-非人灵长类肾异种移植用药研究进展及现状
Shujun Yang,Hao Wei,Haihong Yang et al.
Shujun Yang et al.
Kidney transplantation is the only effective treatment for patients with end-stage renal disease (ESRD). With the application of gene-editing technology and modern immunosuppressants, kidney transplants from pigs with up to 12 edited genes ...
Using machine learning to examine pre-transplant factors influencing De novo HLA-specific antibody development post-kidney transplant [0.03%]
应用机器学习研究肾脏移植受者术后新发HLA特异性抗体的前移植物因素的影响
George E Nita,Alex Rothwell,Matthew Howse et al.
George E Nita et al.
Introduction: The development of de novo donor-specific antibodies (DSAs) against HLA is associated with premature graft failure in kidney transplantation. However, reported rates and contributing factors vary widely. We ...
Regulatory B cells: Synergistic cellular mechanisms and therapeutic potential for alleviating transplant rejection [0.03%]
调节性B细胞：协同机制及缓解移植排斥的治疗潜力
Shaochen Yu,Mengjie Zhang,Ziyue Dou et al.
Shaochen Yu et al.
Posttransplantation rejection remains a critical challenge in organ transplantation. While immunosuppressants improve graft survival, their long-term side effects compromise patient quality of life, necessitating novel, side effect-free str...
The KIR/HLA class I co-expression and transplantation outcomes after HSCT/BMT from HLA-matched sibling donors [0.03%]
KIR/HLA-I配型与同胞相合造血干细胞移植后移植结局关系的研究进展
Joanna Dębska-Zielkowska,Bartosz Słomiński,Hanna Zielińska et al.
Joanna Dębska-Zielkowska et al.
Background: Natural killer (NK) cells express killer immunoglobulin-like receptors (KIRs), which regulate their functions. Self-human leukocyte antigens (HLA) class I molecules act as inhibitory molecules for KIRs, blocki...
The clinical significance of CD45RA+FOXP3low naïve and CD45RA-FOXP3high effector/memory Treg subsets in the development of acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation [0.03%]
CD45RA+FOXP3低 naive和CD45RA-FOXP3高 effecter/memory Tregs亚群在allo-HSCT后急性的移植物抗宿主病中的临床意义
Mani Ramzi,Mohammadnabi Sanaei,Maryam Hesamadini et al.
Mani Ramzi et al.
Introduction: It has been proposed that regulatory T cells (Tregs) might be involved in the induction of transplantation tolerance after allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, little is k...
Roman Gorchs,Matt Stout,Brooke Cohen et al.
Roman Gorchs et al.
Background: Acute rejection in pediatric kidney transplant patients can increase posttransplant costs and lead to limited survival of the graft. Identifying key risk factors for acute rejection in pediatric kidney recipie...
Safety and efficacy of high-dose versus standard-dose influenza vaccines in hematopoietic stem cell transplant recipients: A meta-analysis of randomized controlled trials [0.03%]
高剂量化学药物治疗的造血干细胞移植受者使用高剂量与标准剂量流感疫苗的效果和安全性：随机对照试验的meta分析
Ananda Pipphali Vidya,Nicholas Jason Wijaya,Dhabitah Zahraa Puteri Gathmir et al.
Ananda Pipphali Vidya et al.
Given the vulnerability of hematopoietic cell transplant (HCT) patients to influenza infection and its complications, annual vaccination is recommended. However, vaccination was known to be less effective in these patients. Multiple studies...
Successful use of belumosudil in a patient with chronic ocular GVHD: A case report [0.03%]
布雷莫司汀治疗慢性眼GVHD患者的成功案例报告
Xiaoli Lv,Huibo Li,Zhijian Li et al.
Xiaoli Lv et al.
Background: Belumosudil is a selective ROCK2 inhibitor approved by the U.S. Food and Drug Administration (FDA) for the treatment of patients who have failed at least two prior systemic therapies. By inhibiting ROCK2, Belu...