Pharmacological basis for the potential role of Azithromycin and Doxycycline in management of COVID-19 [0.03%]
阿奇霉素和多西环素在治疗新冠肺炎中潜在作用的药理学依据
Ahmed S Ali,Mai A ASattar,Shahid Karim et al.
Ahmed S Ali et al.
A novel corona virus SARS-CoV-2 has led to an outbreak of the highly infectious pandemic COVID-19 complicated viral pneumonia. Patients with risk factors frequently develop secondary infections where the role of appropriate antibiotics is m...
Potential bioactive compounds as SARS-CoV-2 inhibitors from extracts of the marine red alga Halymenia durvillei (Rhodophyta) - A computational study [0.03%]
基于海洋红藻Halymenia durvillei提取物的潜在生物活性化合物作为SARS-CoV-2抑制剂的计算研究
Asmi Citra Malina A R Tassakka,Ophirtus Sumule,Muhammad Nasrum Massi et al.
Asmi Citra Malina A R Tassakka et al.
The respiratory infection COVID-19 caused by the virus SARS CoV-2 has continued to be a major health problem worldwide and has caused more than a million mortalities. Even if the development of COVID-19 vaccines has shown much progress, eff...
Ahmed S Ali,Ibrahim M Ibrahim,Abdulhadi S Burzangi et al.
Ahmed S Ali et al.
Background: COVID-19 is an ongoing viral pandemic produced by SARS-CoV-2. In light of in vitro efficacy, several medications were repurposed for its management. During clinical use, many of these medications produced inco...
Exploring the interaction of quercetin-3-O-sophoroside with SARS-CoV-2 main proteins by theoretical studies: A probable prelude to control some variants of coronavirus including Delta [0.03%]
通过理论研究探讨檞皮素-3-O- sophoroside与SARS-CoV-2主要蛋白的相互作用：控制包括Delta变体在内的某些冠状病毒的可能前奏
Suliman Khan,Arif Hussain,Yasaman Vahdani et al.
Suliman Khan et al.
The aim of this study was to investigate the mechanism of interaction between quercetin-3-O-sophoroside and different SARS-CoV-2's proteins which can bring some useful details about the control of different variants of coronavirus including...
Structure-based virtual screening and molecular dynamics of phytochemicals derived from Saudi medicinal plants to identify potential COVID-19 therapeutics [0.03%]
基于结构的虚拟筛选和分子动力学模拟：从沙特阿拉伯药用植物中分离出的天然药物化合物潜在COVID-19治疗药物的鉴定
Mubarak A Alamri,Ali Altharawi,Alhumaidi B Alabbas et al.
Mubarak A Alamri et al.
Coronavirus disease 2019 (COVID-19) has affected almost every country in the world by causing a global pandemic with a high mortality rate. Lack of an effective vaccine and/or antiviral drugs against SARS-CoV-2, the causative agent, has sev...
TAT-peptide conjugated repurposing drug against SARS-CoV-2 main protease (3CLpro): Potential therapeutic intervention to combat COVID-19 [0.03%]
用于针对SARS-CoV-2主要蛋白酶(3CL pro)的再利用药物的TAT肽缀合物：潜在的治疗干预措施，以抗击COVID-19
Mohammad Azam Ansari,Qazi Mohammad Sajid Jamal,Suriya Rehman et al.
Mohammad Azam Ansari et al.
The Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) that originated in Chinese city of Wuhan has caused around 906,092 deaths and 28,040,853 confirmed cases worldwide (https://covid19.who.int/, 11 September 2020). In a life-thr...
3D printing and continuous flow chemistry technology to advance pharmaceutical manufacturing in developing countries [0.03%]
3D打印和连续流动化学技术促进发展中国家药物制造产业发展
Cloudius R Sagandira,Margaret Siyawamwaya,Paul Watts
Cloudius R Sagandira
The realization of a downward spiralling of diseases in developing countries requires them to become self-sufficient in pharmaceutical products. One of the ways to meet this need is by boosting the local production of active pharmaceutical ...
Development of superior antibodies against the S-protein of SARS-Cov-2 using macrocyclic epitopes [0.03%]
利用环形表位开发针对SARS-Cov-2刺突蛋白的优质抗体
Hassan Traboulsi,Mohammed A Khedr,Rafea Elgorashe et al.
Hassan Traboulsi et al.
One of the proven methods to prevent and inhibit viral infections is to use antibodies to block the initial Receptor Binding Domain (RBD) of SARS-CoV-2 S protein and avoid its binding with the host cells. Thus, developing these RBD-targetin...