Synthesis, antimicrobial, anticancer, antiviral evaluation and QSAR studies of 4-(1-aryl-2-oxo-1,2-dihydro-indol-3-ylideneamino)- N-substituted benzene sulfonamides [0.03%]
4-(1-芳基-2-氧化-1,2-二氢吲哚-3-亚氨基)-N取代苯磺酰胺的合成、抗菌抗病毒抗癌活性及QSAR研究
Mahesh Kumar,Kalavathy Ramasamy,Vasudevan Mani et al.
Mahesh Kumar et al.
A series of 4-(1-aryl-2-oxo-1,2-dihydro-indol-3-ylideneamino)-N-substituted benzenesulfonamide derivatives (1-32) was synthesized and evaluated for its in vitro antimicrobial, antiviral and cytotoxic activities. Antimicrobial results indica...
A synthesis of (±)-thia-calanolide A, its resolution and in vitro biological evaluation [0.03%]
(±)-硫杂环氯烷啶A的合成、拆分及体外生物活性评价
Anil U Chopade,Manojkumar U Chopade,Bhanu M Chanda et al.
Anil U Chopade et al.
A synthesis of (±)-thia-calanolide A 3 has been successfully accomplished starting from 3,5-dimethoxythiophenol 4, in six steps in an overall yield of 4.5%. The key reaction involved Friedel-Crafts tigloylation of 5,7-dihydroxy-4-n-propyl ...
Structure-based design, and development of amidinyl, amidoximyl and hydroxamic acid based organic molecules as novel antimalarial drug candidates [0.03%]
基于结构设计和发展作为新型抗疟疾药物候选者的酰氨甲基、氨基肟基和羟肟酸类有机分子
Glory P Adebayo,Gbolahan O Oduselu,Damilola V Aderohunmu et al.
Glory P Adebayo et al.
Malaria remains a significant global health concern causing numerous fatalities and the emergence of antimalarial drug resistance highlights the urgent need for novel therapeutic options with innovative mechanisms of action and targets. Thi...
A suitable drug structure for interaction with SARS-CoV-2 main protease between boceprevir, masitinib and rupintrivir; a molecular dynamics study [0.03%]
针对SARS-CoV-2主要蛋白酶的博赛普韦、马西替坦和芦帕曲辛相互作用的适宜药物结构——分子动力学研究
Mehdi Yoosefian,Razieh Dashti,Mohamad Mahani et al.
Mehdi Yoosefian et al.
In recent years, more than 200 countries of the world have faced a health crisis due to the epidemiological disease of COVID-19 caused by the SARS-CoV-2 virus. It had a huge impact on the world economy and the global health sector. Research...
Identification of potential Indonesian marine invertebrate bioactive compounds as TMPRSS2 and SARS-CoV-2 Omicron spike protein inhibitors through computational screening [0.03%]
通过计算筛选识别潜在的印尼海洋无脊椎动物生物活性化合物作为TMPRSS2和SARS-CoV-2奥密克戎刺突蛋白抑制剂
Haviani Rizka Nurcahyaningtyas,Alfrina Irene,Joko Tri Wibowo et al.
Haviani Rizka Nurcahyaningtyas et al.
The coronavirus pandemic led to the announcement of a worldwide health emergency. The SARS-CoV-2 Omicron variant, which swiftly spread worldwide, has fueled existing challenges. Appropriate medication is necessary to avoid severe SARS-CoV-2...
Screening compounds for treating the diabetes and COVID-19 from Miao medicine by molecular docking and bioinformatics [0.03%]
基于分子对接和生物信息学的苗药筛选治疗糖尿病和COVID-19化合物的研究
Feng Xu,Xulong Huang,Hongmei Wu et al.
Feng Xu et al.
Both diabetes and Corona Virus Disease 2019 (COVID-19) are seriously harmful to human health, and they are closely related. It is of great significance to find drugs that can simultaneously treat diabetes and COVID-19. Based on the theory o...
Compounds from myrtle flowers as antibacterial agents and SARS-CoV-2 inhibitors: In-vitro and molecular docking studies [0.03%]
牻牛儿菊素衍生物的抗细菌和抗SARS-CoV-2病毒活性及分子对接研究
Badra Barhouchi,Rafik Menacer,Saad Bouchkioua et al.
Badra Barhouchi et al.
Plants and their related phytochemicals play a key role in the treatment of bacterial and viral infections, which inspire scientists to design and develop more efficient drugs starting from the phytochemical active scaffold. This work aims ...
Prospecting native and analogous peptides with anti-SARS-CoV-2 potential derived from the trypsin inhibitor purified from tamarind seeds [0.03%]
来源于番木瓜种子中提取的胰蛋白酶抑制剂的具有抗SARS-CoV-2潜能的天然和类似肽的筛选研究
Anna Beatriz Santana Luz,Amanda Fernandes de Medeiros,Lucas Lima Bezerra et al.
Anna Beatriz Santana Luz et al.
The study aimed to prospect in silico native and analogous peptides with anti-SARS-CoV-2 potential derived from the trypsin inhibitor purified from tamarind seeds (TTIp). From the most stable theoretical model of TTIp (TTIp 56/287), in sili...
Bio-guided chemical characterization and nano-formulation studies of selected edible volatile oils with potentials antibacterial and anti-SARS-CoV-2 activities [0.03%]
选食挥发油的生物导向化学特征及纳米配方研究，具有抗菌和抗SARS-CoV-2潜力
Mohamed S Refaey,Marwa A A Fayed,Omnia Kutkat et al.
Mohamed S Refaey et al.
The recent pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has opened the door to potential threats of the respiratory system. The discovery of drugs from natural sources is one of the most important strategi...
Unraveling the mechanism of action of cepharanthine for the treatment of novel coronavirus pneumonia (COVID-19) from the perspectives of systematic pharmacology [0.03%]
基于系统药理学的cepharanthine治疗新型冠状病毒肺炎(COVID-19)机制研究
Feifei Sun,Jinde Liu,Ali Tariq et al.
Feifei Sun et al.
Natural products play an irreplaceable role in the treatment of SARS-CoV-2 infection. Nevertheless, the underlying molecular mechanisms involved remain elusive. To better understand their potential therapeutic effects, more validation studi...