Anti-inflammatory or anti-SARS-CoV-2 ingredients in Huashi Baidu Decoction and their corresponding targets: Target screening and molecular docking study [0.03%]
化湿败毒方中抗炎及抗SARS-CoV-2成分及其靶点研究：基于分子对接的筛选分析
Zixuan Wang,Hongwei Gao
Zixuan Wang
Coronavirus disease 2019 (COVID-19) is a rapidly emerging infectious disease caused by SARS-CoV-2. Inflammatory factors may play essential roles in COVID-19 progression. Huashi Baidu Decoction (HSBD) is a traditional Chinese medicine (TCM) ...
New potential anti-SARS-CoV-2 and anti-cancer therapies of chitosan derivatives and its nanoparticles: Preparation and characterization [0.03%]
壳聚糖衍生物及其纳米粒子的潜在抗SARS-CoV-2和抗癌疗法：制备与表征
Mai Ali,Mansoura I Mohamed,Azza T Taher et al.
Mai Ali et al.
Chitosan (CS) is a biopolymer and has reactive amine/hydroxyl groups facilitated its modifications. The purpose of this study is improvement of (CS) physicochemical properties and its capabilities as antiviral and antitumor through modifica...
In silico study of novel niclosamide derivatives, SARS-CoV-2 nonstructural proteins catalytic residue-targeting small molecules drug candidates [0.03%]
针对SARS-CoV-2非结构蛋白催化残基的尼克地农衍生物新药候选分子的药物设计与虚拟筛选研究
Bashir Lawal,Sheng-Kuang Tsai,Alexander T H Wu et al.
Bashir Lawal et al.
The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-mediated coronavirus disease 2019 (COVID-19) infection remains a global pandemic and health emergency with overwhelming social and economic impacts throughout the world. Thera...
Chloroquine chaos and COVID-19: Smart delivery perspectives through pH sensitive polymers/micelles and ZnO nanoparticles [0.03%]
氯喹混乱和COVID-19：通过pH敏感的聚合物/胶束以及ZnO纳米颗粒实现智能传递视角
Anju Manuja,Dharvi Chhabra,Balvinder Kumar
Anju Manuja
The global pandemic of COVID-19 had a consequential impact on our lives. (Hydroxy)chloroquine, a well-known drug for treatment or prevention against malaria and chronic inflammatory conditions, was also used for COVID patients with reported...
Microwave assisted synthesis of 2-amino-4-chloro-pyrimidine derivatives: Anticancer and computational study on potential inhibitory action against COVID-19 [0.03%]
微波促进的2-氨基-4-氯嘧啶衍生物合成及其抗新冠肺炎和抗癌活性及计算研究
Faiza Qureshi,Muhammad Nawaz,Soleiman Hisaindee et al.
Faiza Qureshi et al.
We report microwave synthesis of seven unique pyrimidine anchored derivatives (1-7) incorporating multifunctional amino derivatives along with their in vitro anticancer activity and their activity against COVID-19 in silico. 1-7 were charac...
Pharmacophore model-aided virtual screening combined with comparative molecular docking and molecular dynamics for identification of marine natural products as SARS-CoV-2 papain-like protease inhibitors [0.03%]
基于药效团模型的虚拟筛选结合分子对接及分子动力学模拟鉴定海洋天然产物作为SARS-CoV-2 3CLpro抑制剂
Neelaveni Thangavel,Mohammed Albratty
Neelaveni Thangavel
Targeting SARS-CoV-2 papain-like protease using inhibitors is a suitable approach for inhibition of virus replication and dysregulation of host anti-viral immunity. Engaging all five binding sites far from the catalytic site of PLpro is ess...
Unraveling the mystery of efficacy in Chinese medicine formula: New approaches and technologies for research on pharmacodynamic substances [0.03%]
揭示中药方剂疗效物质基础的奥秘：药效物质研究的新思路与新技术
Yaolei Li,Zhijian Lin,Yu Wang et al.
Yaolei Li et al.
Traditional Chinese medicine (TCM) is the key to unlock treasures of Chinese civilization. TCM and its compound play a beneficial role in medical activities to cure diseases, especially in major public health events such as novel coronaviru...
One-pot synthesis, X-ray crystal structure, and identification of potential molecules against COVID-19 main protease through structure-guided modeling and simulation approach [0.03%]
一步合成法，X射线晶体结构鉴定及通过结构导向建模与模拟筛选的抗新冠肺炎主蛋白酶潜在化合物识别
Youness El Bakri,Malahat Musrat Kurbanova,Sabir Ali Siddique et al.
Youness El Bakri et al.
Although antimicrobial resistance before the Covid-19 pandemic is a top priority for global public health, research is already ongoing on novel organic compounds with antimicrobial and antiviral properties in changing medical environments i...
Ecofriendly and sustainable Sargassum spp.-based system for the removal of highly used drugs during the COVID-19 pandemic [0.03%]
一种环保且可持续的基于大沼藻属（Sargassum）的系统，在COVID-19疫情期间去除常用药物
J Luis López-Miranda,Gustavo A Molina,Rodrigo Esparza et al.
J Luis López-Miranda et al.
Analgesic consumption increased significantly during the COVID-19 pandemic. A high concentration of this kind of drug is discarded in the urine, reaching the effluents of rivers, lakes, and seas. These medicines have brought serious problem...
Synthesis and greener pastures biological study of bis-thiadiazoles as potential Covid-19 drug candidates [0.03%]
双噻二唑的合成及其作为潜在新冠药物候选者的生物研究
Musa A Said,Sayed M Riyadh,Nadia S Al-Kaff et al.
Musa A Said et al.
A novel series of bis- (Abdelhamid et al., 2017, Banerjee et al., 2018, Bharanidharan et al., 2022)thiadiazoles was synthesized from the reaction of precursor dimethyl 2,2'-(1,2-diphenylethane-1,2-diylidene)-bis(hydrazine-1-carbodithioate) ...