The relationship between interfacial overlap and functional divergence in the yeast protein-protein interaction network [0.03%]
酵母蛋白质相互作用网络中的界面叠覆盖度和功能分歧之间的关系
Yilun Han,Mohamed Ghadie,Yu Xia
Yilun Han
Protein-protein interactions (PPIs) and genetic interactions are central to cellular function. We investigate their relationship in the structurally resolved yeast PPI network, specifically the relationship between PPI structural divergence...
Jonathan Webb,Jeremy J M Liew,Andrew D Gnann et al.
Jonathan Webb et al.
The HMG-box protein capicua (CIC) is a conserved transcriptional repressor with key functions in development and disease. CIC binding of DNA requires both its HMG-box and a separate domain called C1. How these domains cooperate to recognize...
Initial leads to combat streptogramin resistance generated from X-ray fragment screening against VatD [0.03%]
基于VatD衍射片段的筛选用于对抗streptogramin抗性的初始先导物生成研究
Pooja Asthana,Sonya Lee,Christian M MacDonald et al.
Pooja Asthana et al.
Streptogramins are potent antibiotics targeting bacterial ribosome. The synergistic binding of group A and B streptogramins to 50S-ribosome yields bactericidal effects. However, their efficacy is compromised by resistance mechanisms, includ...
Structural analysis of ASCH domain-containing proteins and their implications for nucleotide processing [0.03%]
含ASCH结构域蛋白的结构分析及其对核苷酸加工的启示
Chunyan Meng,Xiaoyan Shi,Wenting Guo et al.
Chunyan Meng et al.
ASC-1 homology (ASCH) domain family proteins are believed to play essential roles in RNA metabolism, but detailed structural and functional information is limited. Research has shown that the E. coli enzyme YqfB, which contains an ASCH doma...
Genetically encoded FerriTag as a specific label for cryo-electron tomography [0.03%]
一种遗传编码的FerriTag特异性标记物用于冷冻电子断层扫描
Chang Wang,Amin Khosrozadeh,Ioan Iacovache et al.
Chang Wang et al.
Cryo-electron tomography (cryoET) provides 3D datasets of organelles and proteins at nanometer and sub-nanometer resolution. However, locating target proteins in live cells remains a significant challenge. Conventional labeling methods, suc...
Hao Xu,Yimin Zhang,Qinru Bai et al.
Hao Xu et al.
GABA (g-aminobutyric acid) transporter 3 (GAT3) is primarily found in glial cells and is essential for regulating GABA homeostasis in the central nervous system by mediating GABA uptake. Consequently, GAT3 has emerged as a significant thera...
Kevin D Corbett,Amar Deep
Kevin D Corbett
The structural maintenance of chromosomes (SMC)-family Wadjet complex restricts plasmid transformation in bacteria through a distinctive mechanism coupling DNA loop extrusion and cleavage. In this issue of Structure, Roisné-Hamelin et al.1...
Zhenmei Xu,Yuanzheng He
Zhenmei Xu
Rhodopsins typically harness light energy through the covalently bound retinal cofactor. However, some rhodopsins have lost this ability during evolution. In this issue of Structure, Kovalev et al.1 present the cryo-electron microscopy (cry...
Fungal kinesin-8 motors dimerize by folding their proximal tail domain into a compact helical bundle [0.03%]
真菌kinesin-8 Motor通过将近端尾部结构域折叠成一个紧致的螺旋束而二聚化
Daria Trofimova,Caitlin Doubleday,Byron Hunter et al.
Daria Trofimova et al.
Kinesin-8 motors regulate kinetochore-microtubule dynamics and control spindle length and positioning. Certain isoforms achieve this by traversing microtubules, accumulating at plus-ends, and depolymerizing terminal αβ-tubulin subunits. W...
Structural insights into outer membrane protein biogenesis in pathogenic Neisseria [0.03%]
致病性奈瑟氏菌外膜蛋白生物发生的结构见解
Evan Billings,Zixing Fan,Moloud Aflaki Sooreshjani et al.
Evan Billings et al.
N. gonorrhoeae (Ngo) causes the sexually transmitted infection gonorrhea with ∼106 million infections worldwide annually. Ngo infections can result in an increased risk of acquiring HIV, infertility, and blindness. To combat Ngo infections...