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期刊名:Structure

缩写:STRUCTURE

ISSN:0969-2126

e-ISSN:1878-4186

IF/分区:4.3/Q1

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共收录本刊相关文章索引3345
Clinical Trial Case Reports Meta-Analysis RCT Review Systematic Review
Classical Article Case Reports Clinical Study Clinical Trial Clinical Trial Protocol Comment Comparative Study Editorial Guideline Letter Meta-Analysis Multicenter Study Observational Study Randomized Controlled Trial Review Systematic Review
Maria Del Carmen Fernandez-Ramirez,Binh A Nguyen,Shumaila Afrin et al. Maria Del Carmen Fernandez-Ramirez et al.
Transthyretin amyloidosis is a systemic protein misfolding disorder with diverse clinical phenotypes, including cardiomyopathy, polyneuropathy, or a combination of both. While structural polymorphism of amyloid fibrils has been linked to di...
William S Henriques,Jarrett Bowman,Laina N Hall et al. William S Henriques et al.
Cas1 and Cas2 are the hallmark proteins of prokaryotic adaptive immunity. However, these two proteins are often fused to other proteins and the functional association of these fusions often remain poorly understood. Here we purify and deter...
Evan J McMahon,Alexander G Cioffi,Patrick R Visperas et al. Evan J McMahon et al.
Targeted protein degradation (TPD) leverages the ubiquitin-proteasome system to eliminate disease-causing proteins via E3 ligases. To date, the field is limited to utilizing a few of the over 600 human E3 ligases. To expand this repertoire,...
S M Naimul Hasan,Elnaz Khalili Samani,Alexander F A Keszei et al. S M Naimul Hasan et al.
Mycobiota fatty acid synthases (FASs) catalyze iterative cycles of condensation, dehydration, and reduction to produce saturated fatty acids. Although these multienzymes are attractive antifungal drug targets, no clinically approved small-m...
Nikolaos Louros,Joost Schymkowitz,Frederic Rousseau Nikolaos Louros
In this issue of Structure, Connor et al.1 combine topology and residue-level energetics of α-synuclein and tau fibrils to identify isoenergetic fold families. They reveal how conserved hotspot residues, mutations, and, potentially, enviro...
Fiyaz Mohammed,Carrie R Willcox,Benjamin E Willcox Fiyaz Mohammed
In this issue of Structure, Rashleigh et al.1 used cryoelectron microscopy to assess recognition of the model foreign antigen phycoerythrin (PE) by a γδ TCR, an αβ TCR, and an antibody. With potential relevance for anti-pathogen immunit...
Eva M Huber,Wolfgang Heinemeyer,Michael Groll Eva M Huber
Single point mutations in proteasome subunits can cause severe autoinflammatory syndromes. By still largely unknown mechanisms, some of these disease-associated mutations impair normal proteasome function and induce the production of pro-in...
Chenyao Li,Rouslan G Efremov Chenyao Li
Ryanodine receptors (RyRs) are intracellular tetrameric ion channels responsible for Ca2+ release from the sarcoplasmic and endoplasmic reticulum. Ryanodine receptor 1 (RyR1) isoform, critical for muscle contraction, has been studied most e...
Tianling Guo,Yuxin Zheng,Zheng Fan et al. Tianling Guo et al.
Interleukin-31 (IL-31) signals through the IL-31 receptor alpha (IL-31RA) and oncostatin M receptor beta (OSMRβ) heterodimer, mediating pruritus, dermatitis, inflammatory responses, neuroimmune interactions, and certain cancers. Here, we p...
Yann Vander Meersche,Julien Diharce,Jean-Christophe Gelly et al. Yann Vander Meersche et al.
Release of AlphaFold 2 and subsequent development of AlphaFold 3 had a profound impact on protein structure prediction, providing near-experimental accuracy. However, the utility of AF2's confidence index (pLDDT) as indicators of protein fl...