Cryo-EM structures of photocomplexes from the free-living aerobic anoxygenic phototrophic bacterium Erythrobacter sanguineus [0.03%]
来自好氧无氧光合细菌红细菌的光复合物的 cryo-em 结构
Xing-Yu Yue,Guang-Lei Wang,Mei-Juan Zou et al.
Xing-Yu Yue et al.
Aerobic anoxygenic phototrophic bacteria (AAPB) are widely distributed in nature and they are important members of the marine phototrophic community. However, a structural and functional understanding of the AAPB photosynthetic apparatus is...
Structural changes shifting the redox potential of the outlying cluster N1a in respiratory complex I [0.03%]
结构变化改变了呼吸复合物I边缘区簇N1a的氧化还原电位
Daniel Wohlwend,Thilo Seifermann,Emmanuel Gnandt et al.
Daniel Wohlwend et al.
Energy-converting NADH:ubiquinone oxidoreductase, respiratory complex I, is central to energy metabolism by coupling NADH oxidation and quinone reduction with proton translocation across the membrane. Electrons are transferred from the prim...
Memory engram synapse 3D macromolecular architecture visualized by cryoCLEM-guided cryoET [0.03%]
利用cryoCLEM引导的cryoET可视化记忆印痕突触三维宏分子结构
Charlie Lovatt,Thomas O&#x;Sullivan,Clara Ortega-de San Luis et al.
Charlie Lovatt et al.
Memory is incorporated into the brain as physicochemical changes to engram cells. These neuronal populations form complex neuroanatomical circuits, are modified by experiences to store information, and allow memory recall. At the molecular ...
Cradle loop regulates β-barrel pore-formation mechanism of Vibrio cholerae cytolysin [0.03%]
稳压器循环调节霍乱毒素β barrel孔形成机制
Mahendra Singh,Arnab Chatterjee,Ananya Nayak et al.
Mahendra Singh et al.
Vibrio cholerae cytolysin (VCC) is a β-barrel pore-forming toxin (β-PFT). The membrane insertion of its pore-forming "pre-stem" motif is the most crucial step in the pore-formation mechanism. In the soluble monomeric form, pre-stem remain...
Jessey Erath,Slavica Pavlovic Djuranovic
Jessey Erath
In a recent issue of Nature Structural & Molecular Biology, Anton et al.1 produce the first in situ visualization of Plasmodium falciparum ribosomes within infected erythrocytes. Using cryoelectron tomography and cryoelectron microscopy, te...
Yaxin Dai,Chia-Hsueh Lee
Yaxin Dai
Why do certain drugs bind human OAT1 with much higher affinity than the rat ortholog? In this issue of Structure, Jeon et al.1 reveal that serine 203, which is present only in human OAT1, coordinates with a chloride ion and this S203-chlori...
Soft X-ray tomography illuminates drug-induced changes in insulin granules [0.03%]
软X射线断层扫描揭示药物引起胰岛素颗粒的变化
Natalia Fuchs,Venera Weinhardt
Natalia Fuchs
In this issue of Structure, Deshmukh et al.1 reveal that β cells actively remodel insulin secretory granules in response to specific physiological cues, altering granule density, proinsulin processing, and spatial distribution. This stimul...
Catalytic mechanism and differential alarmone regulation of a conserved stringent nucleosidase [0.03%]
一种保守的严格型核苷酶的催化机制及不同报警物的调节作用
René L Bærentsen,Kristina Kronborg,Ditlev E Brodersen et al.
René L Bærentsen et al.
Insights into bacterial metabolic adaptation during stress is crucial for understanding early mechanisms of antibiotic resistance. In the Gram-negative bacterium Escherichia coli, the universal stringent response produces the alarmones (p)p...
Structural basis of isethionate transport by a TRAP transporter from a sulfate-reducing bacterium [0.03%]
来自产硫还原菌的TRAP转运蛋白结合异硫酸盐的结构基础
Michael C Newton-Vesty,Mariafrancesca Scalise,Sam A Jamieson et al.
Michael C Newton-Vesty et al.
Sulfate-reducing bacteria import organosulfur compounds from the environment for anaerobic respiration. They contribute to human disease and are problematic in industrial settings because they produce hydrogen sulfide. Here, we demonstrate ...
Huifang Yan,Fengyun Ni,Qinghua Wang et al.
Huifang Yan et al.
Propionyl-CoA carboxylase (PCC) is a biotin-dependent mitochondrial enzyme responsible for propionyl-CoA catabolism. Deficiencies in human PCC (hPCC) cause propionic acidemia, a severe metabolic disorder driven by toxic metabolite accumulat...