Decoding the molecular choreography of colibactin: Structural insights into a genotoxic assembly line [0.03%]
大肠杆菌colibactin蛋白结构解析：一类具有遗传毒性的蛋白质装配线
Dandan Li,Zhijun Wang
Dandan Li
The evolutionary fusion of modular polyketide synthase (PKS) and nonribosomal peptide synthetase (NRPS) pathways unlocks chemical space that is inaccessible to either system alone. In this issue of Structure, Kim et al.1 present cryoelectro...
AI-guided cryo-EM analysis untangles uromodulin lattices that safeguard kidneys [0.03%]
人工智能引导的低温电磁分析解开保护肾脏的尿膜蛋白晶格结构
Kelvin Han Chung Chong,Bin Wu
Kelvin Han Chung Chong
In this issue of Structure, Chang et al.1 combined deep-learning cryoelectron microscopy (cryo-EM) particle picking and heterogeneous refinement to obtain structures of human uromodulin filament lattices that were isolated from urine sample...
Modeling phase separation of biomolecular condensates with data-driven mass-conserving reaction-diffusion systems [0.03%]
数据驱动的守恒反应扩散系统在生物分子凝聚体相分离建模中的应用
Cheng Li,Man-Ting Guo,Xiaoqing He et al.
Cheng Li et al.
Phase separation, as one important type of pattern formation, plays a critical role in regulating cellular processes and sustaining ecological resilience. Mass-conserving reaction-diffusion (MCRD) models have been proposed to capture the un...
Structural insights into the biotechnologically relevant reversible NADPH-oxidizing NiFe-hydrogenase from P.furiosus [0.03%]
来自P.furiosus的可逆型NADPH氧化NiFe氢酶的结构洞察
Xiansha Xiao,Gerrit J Schut,Xiang Feng et al.
Xiansha Xiao et al.
The cytoplasmic hydrogenase I (SHI) from the hyperthermophilic archaeon Pyrococcus furiosus belongs to the group III hydrogenase family. SHI oxidizes NADPH rather than NADH to reduce protons and evolve hydrogen gas, and because of this prop...
Deveney Dasilva,Nivea Pereira de Sa,Kathryn Takemura et al.
Deveney Dasilva et al.
Invasive fungal infections (IFIs) caused by pathogenic fungi are a major public health concern, particularly across various immunocompromised populations. Effective clinical management is currently hindered by limited treatment options. Fun...
Rapid hepatitis C virus replication machinery removal after antiviral treatment with DAA monitored by multimodal imaging [0.03%]
全口服直接抗病毒药物治疗可快速清除丙型肝炎病毒感染——多模式影像学监测显示
Victoria Castro,Gema Calvo,Ana J Pérez-Berná et al.
Victoria Castro et al.
Hepatitis C virus (HCV) replication causes a profound remodeling of the host endomembrane system. The availability of direct-acting antiviral (DAA) drugs provides an opportunity to define the ultrastructural events that follow viral replica...
High throughput cryo-EM provides structural understanding for modulators of the lysosomal ion channel TRPML1 [0.03%]
高通量冷冻电镜解析调控溶酶体离子通道TRPML1的小分子及其复合物结构
Judith Reeks,Pravin Mahajan,Mellissa Clark et al.
Judith Reeks et al.
Access to high-resolution structural data for protein-ligand complexes is a prerequisite for structure-based medicinal chemistry, where the ability to iterate cycles of design-structure-redesign is highly desirable. For proteins refractory ...
Xiaoli Lu,Jinfeng Chen,Jing Huang
Xiaoli Lu
Biomolecular force fields have continuously evolved to improve their accuracy and broaden their applications in biological and therapeutic discoveries. The rapid adaptation of advanced computational technology, in particular the recent deep...
Redefining the role of the EryM acetyltransferase in natural product biosynthetic pathways [0.03%]
从头设计色氨酰-tRNA合成酶乙酰转移酶在天然产物生物合成途径中的作用
Yihua Li,Xunkun Liu,Natalia R Harris et al.
Yihua Li et al.
The GNAT (GCN5-related N-acetyltransferase) superfamily comprises enzymes with a conserved fold and diverse catalytic activities, including primarily acyl transfer, with a few examples of decarboxylation. EryM, a GNAT from Saccharopolyspora...
A class III ligand oscillates between internal and terminal binding modes as it engages with the Dishevelled PDZ domain [0.03%]
一类配体在与Dishevelled PDZ结构域相互作用过程中在内部和末端结合模式间转换
Jitender Kumar,Miroslav Micka,Jan Komárek et al.
Jitender Kumar et al.
One of the largest domain-motif interactomes in human involves PSD-95/Discs-large/ZO-1 (PDZ) domains. The framework for understanding the PDZ interactome is well established; however the functional dynamics associated with PDZ-ligand intera...