Amyloid-motif-dependent tau self-assembly is modulated by isoform sequence context [0.03%]
淀粉样蛋白模序依赖的tau自我装配通过亚型序列上下文调节
Sofia Bali,Pawel M Wydorski,Ruhar Singh et al.
Sofia Bali et al.
The microtubule-associated protein tau is implicated in neurodegenerative diseases characterized by amyloid formation. Mutations associated with frontotemporal dementia increase tau aggregation propensity and disrupt its endogenous microtub...
Jakob R Riccabona,Johannes R Loeffler,Clara T Schoeder et al.
Jakob R Riccabona et al.
Deep-learning models have transformed structural biology by enabling reliable prediction of protein 3D structure models and providing confidence metrics such as predicted local distance difference test (pLDDT) to estimate local uncertaintie...
Capture first, then deliver! [0.03%]
先吸引再转化！
Iktae Kim,Jeong-Yong Suh
Iktae Kim
In this issue of Structure, Henriques et al.1 present structural snapshots that capture distinct conformational states of the type I-F Cas1-Cas2/3 integrase complex, illustrating that foreign DNA binding triggers a large-scale domain rearra...
Cryo-EM structure of drug-resistant Escherichia coli phage E1004 reveals a conserved cylindrical core among podophages [0.03%]
药物耐药的埃希氏大肠杆菌噬菌体E1004的冷冻电镜结构揭示了尾丝噬菌体中保守的圆柱形核心
Binning Sun,Jing Zheng,Yuan Fu et al.
Binning Sun et al.
Podophage tails are too short to traverse the cell envelope and require internal core proteins to assemble into a transmembrane channel for genome delivery during infection. However, high-resolution structures of near-complete cores remain ...
The therapeutic antibody sacituzumab induces trophoblast cell-surface antigen-2 conformational rearrangement [0.03%]
治疗性抗体Sacituzumab可诱导胎盘滋养细胞表面抗原-2构象重排
Ryan Ferrao,Jinjin Zhang,Chih-Chien Chou et al.
Ryan Ferrao et al.
Sacituzumab govitecan (SG) is a therapeutic antibody-drug conjugate globally approved for the treatment of breast cancer. SG targets the trophoblast cell-surface antigen-2 (Trop2) at the surface of cancer cells to deliver the cytotoxic topo...
Protein model building for intermediate-resolution cryo-EM maps by integrating evolutionary and experimental information [0.03%]
通过整合进化和实验信息在中等分辨率的冷冻电镜密度图上构建蛋白质模型
Ji Chen,Tao Li,Jiahua He et al.
Ji Chen et al.
Accurate model building in intermediate-resolution cryo-EM maps normally requires flexible fitting of reliable initial structures. However, while deep learning-based methods such as AlphaFold2 can predict highly accurate structures, the pre...
Structural basis for binding of RILPL1 to TMEM55B reveals a lysosomal platform for adaptor assembly through a conserved peptide motif [0.03%]
RILPL1与TMEM55B的结合基础揭示了通过保守肽基序组装适应性蛋白复合物的溶酶体平台
Dieter Waschbüsch,Prosenjit Pal,Raja S Nirujogi et al.
Dieter Waschbüsch et al.
Inherited mutations in VPS35 and LRRK2 kinase lead to hyperphosphorylation of Rab GTPases. RH2 domain-containing proteins from the RILP homology family, such as RILPL1, are Rab effectors that recognize the LRRK2-phosphorylated switch 2 thre...
Cryo-EM structures of HBV capsids from human cells at near-atomic resolution [0.03%]
人源细胞中HBV壳颗粒的近原子分辨率 cryo-EM 结构
Emily N Bianchini,Carolina Pérez-Segura,Haitao Liu et al.
Emily N Bianchini et al.
HBV causes chronic infections that can lead to severe liver disease, yet current treatments rarely achieve a cure. The HBV capsid is a critical therapeutic target, but structural insights have largely relied on E. coli-derived particles lac...
Muscle-specific tyrosine kinase activation by a peptide-based dimerizer is orientation dependent [0.03%]
基于肽的二聚体化剂激活肌肉特异性酪氨酸激酶具有方向依赖性
Fumiya Mizutani,Kyoko Matoba,Hayden Peacock et al.
Fumiya Mizutani et al.
Muscle-specific receptor tyrosine kinase (MuSK) is a single-pass transmembrane protein expressed on skeletal muscle. MuSK is activated by binding of nerve-derived agrin with the help of muscle coreceptor LRP4, leading to the clustering of a...
A PIP2-stabilized syntaxin-1a structure mapped with transition metal ion FRET and unnatural fluorescent amino acids at the plasma membrane [0.03%]
基于金属离子FRET和非天然荧光氨基酸的质膜结合的PIP2稳定形式的syntaxin-1a结构测定
Kazuki Obashi,Marie-Paule Strub,Justin W Taraska
Kazuki Obashi
Ca2+-triggered exocytosis from neurons and endocrine cells is regulated by neuronal soluble N-ethylmaleimide-sensitive factor attachment receptor (SNARE) proteins. Conformational changes in syntaxin-1-the plasma membrane t-SNARE-are essenti...