The role of carbohydrate component of recombinant α7 nicotinic acetylcholine receptor extracellular domain in its immunogenicity and functional effects of resulting antibodies [0.03%]
重组α7烟碱乙酰胆碱受体胞外区糖基成分在其免疫原性及诱导抗体功能效应中的作用研究
Olena Lykhmus,Lyudmyla Koval,Dar&#x;ya Pastuhova et al.
Olena Lykhmus et al.
Nicotinic acetylcholine receptors of α7 subtype (α7 nAChRs) attenuate the inflammatory cytokines production by macrophages and are involved in pathogenesis of Alzheimer disease by directly influencing the processing of amyloid-beta (Aβ) ...
Pathogen-associated porin turns IL-10 competent B-1a cells toward proinflammatory cytokine response [0.03%]
病原相关孔蛋白使IL-10有能力的B-1a细胞转向促炎症细胞因子反应
Amlan Kanti Ghosh,Debolina Sinha,Ratna Biswas et al.
Amlan Kanti Ghosh et al.
Shigellosis is a major problem in the developing countries causing mortality and morbidity particularly among the children. Shigella spp. harbours the epithelial cells of the human colon to infect the host and spread the disease. We analyze...
Hyperglycemia induces mixed M1/M2 cytokine profile in primary human monocyte-derived macrophages [0.03%]
高血糖使单核细胞来源的人巨噬细胞产生混合M1 / M2型细胞因子谱
Kondaiah Moganti,Feng Li,Christina Schmuttermaier et al.
Kondaiah Moganti et al.
Hyperglycaemia is a key factor in diabetic pathology. Macrophages are essential regulators of inflammation which can be classified into two major vectors of polarisation: classically activated macrophages (M1) and alternatively activated ma...
Innate and adaptive immunologic functions of complement in the host response to Listeria monocytogenes infection [0.03%]
补体在宿主抵抗单核细胞增生李斯特菌感染的固有和适应性免疫反应中的作用
Daniel G Calame,Stacey L Mueller-Ortiz,Rick A Wetsel
Daniel G Calame
Listeria monocytogenes is a leading cause of foodborne-illness associated mortality that has attracted considerable attention in recent years due to several significant outbreaks. It has also served as a model organism for the study of intr...
Complement analysis 2016: Clinical indications, laboratory diagnostics and quality control [0.03%]
补体分析2016：临床指标、实验室诊断和质量控制
Zoltán Prohászka,Bo Nilsson,Ashley Frazer-Abel et al.
Zoltán Prohászka et al.
In recent years, complement analysis of body fluids and biopsies, going far beyond C3 and C4, has significantly enhanced our understanding of the disease process. Such expanded complement analysis allows for a more precise differential diag...
Hydroxytyrosol modulates Par j 1-induced IL-10 production by PBMCs in healthy subjects [0.03%]
羟基酪醇通过调节健康受试者PBMCs中Par j 1诱导的IL-10产生而发挥抗炎作用
Angela Bonura,Sara Vlah,Alessandra Longo et al.
Angela Bonura et al.
Several papers have demonstrated the importance of substances from natural sources which can exert powerful anti-inflammatory effects. In this respect, hydroxytyrosol, one of the major elements of the phenolic components of olive oil, has b...
Complement triggers relocation of Mortalin/GRP75 from mitochondria to the plasma membrane [0.03%]
补体触发Mortalin/GRP75从线粒体向质膜重新定位
Niv Mazkereth,Francesco Rocca,Jennifer-Rose Schubert et al.
Niv Mazkereth et al.
Mortalin/GRP75 is a ubiquitously expressed mitochondrial chaperon that is overexpressed in cancer. Mortalin protects cells from complement-dependent cytotoxicity (CDC) and facilitates elimination of the complement C5b-9 complexes from the c...
Immune response of macrophages induced by Porphyromonas gingivalis requires HmuY protein [0.03%]
牙龈卟啉单胞菌诱导巨噬细胞免疫反应需要血红素载体蛋白HmuY
Anna Gmiterek,Anna Kłopot,Halina Wójtowicz et al.
Anna Gmiterek et al.
The main etiologic agent and a key pathogen responsible for initiation and progression of chronic periodontitis is Porphyromonas gingivalis. We examined the role of P. gingivalis, with particular interest to HmuY protein, in expression of g...
TGF-β signaling regulates resistance to parasitic nematode infection in Drosophila melanogaster [0.03%]
DNF信号调节果蝇寄生线虫感染的抗性
Ioannis Eleftherianos,Julio Cesar Castillo,Jelena Patrnogic
Ioannis Eleftherianos
Over the past decade important advances have been made in the field of innate immunity; however, our appreciation of the signaling pathways and molecules that participate in host immune responses to parasitic nematode infections lags behind...
The role of macrophages in anti-inflammatory activity of antidepressant drugs [0.03%]
抗抑郁药物的抗炎作用中的巨噬细胞的作用
Katarzyna Nazimek,Spencer Strobel,Paweł Bryniarski et al.
Katarzyna Nazimek et al.
Depression is a common disease influencing patients' quality of life, whose etiology involves complex interactions of environmental, genetic and immunological factors. The latter factors include proinflammatory activation of monocytes and m...