MIF-driven activation of macrophages induces killing of intracellular Trypanosoma cruzi dependent on endogenous production of tumor necrosis factor, nitric oxide and reactive oxygen species [0.03%]
MIF通过驱动巨噬细胞活化诱导溶菌作用从而清除胞内克鲁氏锥虫依赖于肿瘤坏死因子、一氧化氮及活性氧的内源性产生
Romina A Cutrullis,Patricia B Petray,Ricardo S Corral
Romina A Cutrullis
The proinflammatory cytokine macrophage migration inhibitory factor (MIF) is a key player in innate immunity. MIF has been considered critical for controlling acute infection by the protozoan Trypanosoma cruzi, but the underlying mechanisms...
Cord and blood levels of newborn IgE: Correlation, role and influence of maternal IgE [0.03%]
新生儿血清和脐带血IgE水平及其相关性、母体IgE的影响
M De Amici,F Perotti,G L Marseglia et al.
M De Amici et al.
The role of cord blood immunoglobulin E (IgE) levels in predicting the development of atopy has been widely investigated. The aim of the study was to evaluate the correlation between serum and cord blood total IgE in newborns and the possib...
NKT cell activation by Leishmania mexicana LPG: Description of a novel pathway [0.03%]
莱什曼原虫脂磷酸甘油激活NK T细胞：一个新的信号转导途径描述
Jaime Zamora-Chimal,Edith A Fernández-Figueroa,Adriana Ruiz-Remigio et al.
Jaime Zamora-Chimal et al.
NKT cells have been associated with protection against Leishmania donovani, yet their role in infections with Leishmania mexicana has not been addressed, nor has the activation pathway been defined after stimulation with Leishmania mexicana...
Activated NKT cells facilitated functional switch of myeloid-derived suppressor cells at inflammation sites in fulminant hepatitis mice [0.03%]
活化的NKT细胞促进肝炎小鼠炎症部位来源的髓系抑制细胞的功能转换
Danxiao Wu,Yu Shi,Cheng Wang et al.
Danxiao Wu et al.
Myeloid-derived suppressor cells (MDSCs) confer immunosuppressive properties, but their roles in fulminant hepatitis have not been well defined. In this study, we systematically examined the distribution of MDSCs in bone marrow (BM), liver ...
Human IgGs induce synthesis and secretion of IgGs and neonatal Fc receptor in human umbilical vein endothelial cells [0.03%]
人IgG诱导人脐静脉内皮细胞IgG的合成分泌及新生儿Fc受体表达
Giulia Frigo,Elisa Tramentozzi,Genny Orso et al.
Giulia Frigo et al.
Human IgGs are increasingly used in the therapy of many different immune and inflammatory diseases, however their mechanism of action still remains unclear in most diseases. To gain insight into the mechanism by which IgGs might also exert ...
Marcia Campillo-Navarro,Kahiry Leyva-Paredes,Luis Donis-Maturano et al.
Marcia Campillo-Navarro et al.
Mast cells play an essential role in different immunological phenomena including allergy and infectious diseases. Several bacteria induce mast cell activation leading to degranulation and the production of several cytokines and chemokines. ...
Tumor-associated macrophages in human breast cancer parenchyma negatively correlate with lymphatic metastasis after neoadjuvant chemotherapy [0.03%]
新辅助化疗后人乳腺癌实质中肿瘤相关巨噬细胞与淋巴转移负相关
Irina Mitrofanova,Marina Zavyalova,Nadezhda Telegina et al.
Irina Mitrofanova et al.
Breast cancer is the leading cause of cancer death in women worldwide with high morbidity and mortality. Tumor-associated macrophages (TAM) are major innate immune cells in the tumor microenvironment controlling primary tumor growth and met...
Evaluation of serum levels of IL-9 and IL-17 in human Schistosoma mansoni infection and their relationship with periportal fibrosis [0.03%]
血清中IL-9和IL-17水平在人曼氏裂头蚴病的评估及其与门脉周围纤维化的关系
Ana Virgínia Matos Sá Barreto,Glaucia Alyne Nunes de Lacerda,Anna Lígia de Castro Figueiredo et al.
Ana Virgínia Matos Sá Barreto et al.
Serum levels of IL-9 and IL-17 cytokines were evaluated in patients in the acute, chronic phases and clinical forms of human schistosomiasis and in different classifications of periportal fibrosis. No significant differences between the gro...
Dock10 regulates CD23 expression and sustains B-cell lymphopoiesis in secondary lymphoid tissue [0.03%]
Dock10调节CD23表达并维持次级淋巴组织中的B细胞淋巴生成
Azahara-María García-Serna,María-José Alcaraz-García,Natalia Ruiz-Lafuente et al.
Azahara-María García-Serna et al.
Dock10, a guanine nucleotide exchange factor for the Rho GTPases Rac1 and Cdc42, affects cell morphology, membrane protrusive activity, and cell movement. Dock10 is prominently expressed in lymphoid tissue and upregulated by IL-4 in B cells...
Downregulation of miR-3940-5p promotes T-cell activity by targeting the cytokine receptor IL-2R gamma on human cutaneous T-cell lines [0.03%]
miR-3940-5p低表达通过靶向细胞因子受体IL-2RG促进人类皮肤T细胞系活性
Yi Wang,Keyu Wang,Ningning Dang et al.
Yi Wang et al.
Vitiligo is a common established depigmentation skin disease characterized by the presence of activated T lymphocytes anti melanocytes within the skin. T-cell immunity mainly mediates the destruction of melanocytes and is one of the main me...