Extravascular hemolysis and complement consumption in Paroxysmal Nocturnal Hemoglobinuria patients undergoing eculizumab treatment [0.03%]
补体耗竭和溶血状态下的依库珠单抗的治疗效果分析——依库珠单抗治疗PNH患者的回顾性研究
Marta Subías Hidalgo,Hector Martin Merinero,Alicia López et al.
Marta Subías Hidalgo et al.
Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired hemolytic anemia characterized by complement-mediated intravascular hemolysis that is effectively treated with eculizumab. However, treatment responses are reported heterogeneous with...
Altered B cell homeostasis and Toll-like receptor 9-driven response in patients affected by autoimmune polyglandular syndrome Type 1: Altered B cell phenotype and dysregulation of the B cell function in APECED patients [0.03%]
自身免疫性多腺体综合征1型患者中B淋巴细胞稳态和 toll 样受体 9 驱动的反应异常：APECED 患者中 B 淋巴细胞表型改变及 B 细胞功能失调
Valentina Perri,Elena Gianchecchi,Riccardo Scarpa et al.
Valentina Perri et al.
APECED is a T-cell mediated disease with increased frequencies of CD8+ effector and reduction of FoxP3+ T regulatory cells. Antibodies against affected organs and neutralizing to cytokines are found in the peripheral blood. The contribution...
Breastfeeding and IL-10 levels in children affected by cow's milk protein allergy: A restrospective study [0.03%]
儿童牛奶蛋白过敏的母乳喂养与IL-10水平的相关性研究回顾式研究
Sara Manti,Vassilios Lougaris,Caterina Cuppari et al.
Sara Manti et al.
Aim: To assess the protective role of breast-feeding in infants with CMPA-related AEDS as well as IL-10 utility as marker of disease evolution. Methods: ...
Association of the I148M/PNPLA3 (rs738409) polymorphism with premature coronary artery disease, fatty liver, and insulin resistance in type 2 diabetic patients and healthy controls. The GEA study [0.03%]
PNPLA3 (rs738409) I148M多态性与2型糖尿病患者和健康对照者冠心病、脂肪肝及胰岛素抵抗的关系：GEA研究
Rosalinda Posadas-Sánchez,Ángel René López-Uribe,Carlos Posadas-Romero et al.
Rosalinda Posadas-Sánchez et al.
The aim of this study was to evaluate the potential use of the I148M/PNPLA3 (rs738409) gene polymorphism as a susceptibility marker for premature coronary artery disease (pCAD) and/or cardiovascular risk factors in Mexican type 2 diabetes m...
Evaluation of a nanotechnology-based approach to induce gene-expression in human THP-1 macrophages under inflammatory conditions [0.03%]
评估纳米技术在炎症条件下诱导人THP-1巨噬细胞基因表达的方法
Laura Bernal,Abigail Alvarado-Vázquez,David Wilson Ferreira et al.
Laura Bernal et al.
Macrophages orchestrate the initiation and resolution of inflammation by producing pro- and anti-inflammatory products. An imbalance in these mediators may originate from a deficient or excessive immune response. Therefore, macrophages are ...
Leishmania infantum antigens modulate memory cell subsets of liver resident T lymphocyte [0.03%]
利什曼原虫幼虫型抗原调节肝驻T淋巴细胞亚群记忆细胞
A Rodrigues,M Claro,G Alexandre-Pires et al.
A Rodrigues et al.
In the recent years, the liver has been recognized as an important immune organ with major regulatory functions and immune memory, adding to the well-described vital metabolic functions. There are evidences from experimental infections perf...
Mohamed Ahmed,Menno P J de Winther,Jan Van den Bossche
Mohamed Ahmed
The alarming rise of obesity and type 2 diabetes (T2D) has put a tremendous strain on global healthcare systems. Over the past decade extensive research has focused on the role of macrophages as key mediators of inflammation in T2D. The inf...
PLA2G2A polymorphisms are associated with metabolic syndrome and type 2 diabetes mellitus. Results from the genetics of atherosclerotic disease Mexican study [0.03%]
PLA2G2A基因多态性与代谢综合征和2型糖尿病的关联研究——来自墨西哥动脉粥样硬化遗传学研究的结果
Irma Eloisa Monroy-Muñoz,Javier Angeles-Martinez,Rosalinda Posadas-Sánchez et al.
Irma Eloisa Monroy-Muñoz et al.
The secretory phospholipase A2 II A (sPLA2-IIA) encoded by PLA2G2A gene hydrolyzes phospholipids liberating free fatty acids (FFAs) and lysophospholipids. If lipolysis exceeds lipogenesis, the free fatty acids undergo a continuous release i...
Poly I:C primes the suppressive function of human palatine tonsil-derived MSCs against Th17 differentiation by increasing PD-L1 expression [0.03%]
聚I:C通过提高PD-L1的表达增强人腭扁桃体来源的MSCs对Th17分化的抑制功能
Kyung-Ah Cho,Minhwa Park,Yu-Hee Kim et al.
Kyung-Ah Cho et al.
It has been established that mesenchymal stem cells (MSCs) can have a suppressive effect on T cells, yet much remains unknown about the underlying mechanisms that support this effect. The T cell co-stimulatory pathway involving the programm...
Pneumococcal DnaJ modulates dendritic cell-mediated Th1 and Th17 immune responses through Toll-like receptor 4 signaling pathway [0.03%]
肺炎链球菌DnaJ通过 toll 样受体 4 信号转导途径调节树突状细胞介导的 Th1 和 Th17 免疫应答
Yingying Wu,Jingjing Cui,Xuemei Zhang et al.
Yingying Wu et al.
Pneumococcal DnaJ was recently shown to be a potential protein vaccine antigen that induces strong Th1 and Th17 immune response against streptococcus pneumoniae infection in mice. However, how DnaJ mediates T cell immune response against S....