Phagocytizing activity of PMN from severe trauma patients in different post-traumatic phases during the 10-days post-injury course [0.03%]
严重创伤患者伤后10天内不同时间段PMN吞噬功能的改变
Ramona Sturm,David Heftrig,Katharina Mörs et al.
Ramona Sturm et al.
Objective: Phagocytizing leukocytes (granulocytes and monocytes) play a fundamental role in immunological defense against pathogens and clearance of cellular debris after tissue injury due to trauma. According to the "two...
Genistein improves thyroid function in Hashimoto's thyroiditis patients through regulating Th1 cytokines [0.03%]
染料木素通过调节Th1细胞因子改善桥本氏病患者的甲状腺功能
Kaili Zhang,Ying Wang,Weiyuan Ma et al.
Kaili Zhang et al.
Hashimoto thyroiditis (HT) is a common autoimmune disease. Genistein is an isoflavone with immunomodulatory functions in various diseases. In this double-blind, randomized, placebo-controlled clinical study, we investigated the effects of g...
Pneumocystis infection alters the activation state of pulmonary macrophages [0.03%]
肺炎克苏鲁寄生菌感染改变肺巨噬细胞的活化状态
Jessica M Deckman,Cathryn J Kurkjian,Joseph P McGillis et al.
Jessica M Deckman et al.
Recent studies show a substantial incidence of Pneumocystis jirovecii colonization and infection in patients with chronic inflammatory lung conditions. However, little is known about the impact of Pneumocystis upon the regulation of pulmona...
Jon Andoni Sánchez,Amparo Alfonso,Olivier P Thomas et al.
Jon Andoni Sánchez et al.
Previous works with autumnalamide reported that Store Operated Calcium (SOC) channels were blocked through mitochondrial modulation. In the present paper we studied the effect of autumnalamide on ionomycin Ca2+ fluxes. Thus, autumnalamide d...
Both intrinsic and extrinsic apoptotic pathways are involved in Toll-like receptor 4 (TLR4)-induced cell death in monocytic THP-1 cells [0.03%]
toll样受体4诱导的单核细胞凋亡涉及内源性和外源性两条途径
Bei Liu,Ruili Sun,Hongbo Luo et al.
Bei Liu et al.
Our previous study showed that TLR3 induces apoptosis via both death receptors and mitochondial in human endothelial cells. We report here that the activation of TLR4 induced dose- and time-dependent cell death in moncytic THP-1 cells. LPS ...
STA-21, a STAT-3 inhibitor, attenuates the development and progression of inflammation in collagen antibody-induced arthritis [0.03%]
STA-21（一种STAT-3抑制剂）能够减缓抗胶原蛋白诱导的关节炎炎症的发展及恶化症状
Sheikh Fayaz Ahmad,Mushtaq Ahmad Ansari,Ahmed Nadeem et al.
Sheikh Fayaz Ahmad et al.
We set out to investigate the influence of STA-21, a dynamic STAT-3 inhibitor, on the expansion and progression of rheumatoid arthritis (RA), and to determine its potential mechanisms of action in a mouse model of collagen antibody-induced ...
Vincent Sam Yong Tchang,Michael Stiess,Kerstin Siegmund et al.
Vincent Sam Yong Tchang et al.
Coronin 1, a member of the evolutionary conserved WD repeat protein family of coronin proteins is expressed in all leukocytes, but a role for coronin 1 in natural killer (NK) cell homeostasis and function remains unclear. Here, we have anal...
Non-redundant role of the chemokine receptor CX3CR1 in the anti-inflammatory function of gut macrophages [0.03%]
肠道巨噬细胞的抗炎功能中化学引诱素受体CX3CR1发挥非冗余作用
G Marelli,C Belgiovine,A Mantovani et al.
G Marelli et al.
Mucosal immunity at the intestinal level is constantly challenged by the presence of external food and microbial antigens and must be kept under strict control to avoid the rise of aberrant inflammation. Among cells of the innate immunity, ...
Lidiana Flora Vidoto da Costa,Anuska Marcelino Alvares-Saraiva,Paulo Ricardo Dell&#x;Armelina Rocha et al.
Lidiana Flora Vidoto da Costa et al.
Encephalitozoon cuniculi is an opportunist intracellular pathogen of mammals. The adaptive immune response is essential to eliminate E. cuniculi, but evidence is mounting that the response initiated by the innate immune response may ultimat...
A vaccine composed of a hypothetical protein and the eukaryotic initiation factor 5a from Leishmania braziliensis cross-protection against Leishmania amazonensis infection [0.03%]
一种假想蛋白质和Leishmania braziliensis的真核起始因子5a组成的疫苗对莱什曼原虫亚马逊ensis感染的交叉保护作用
Mariana Costa Duarte,Daniela Pagliara Lage,Vívian Tamietti Martins et al.
Mariana Costa Duarte et al.
In the present study, two proteins cloned from Leishmania braziliensis species, a hypothetical protein (LbHyp) and the eukaryotic initiation factor 5a (EiF5a), were evaluated to protect BALB/c mice against L. amazonensis infection. The anim...