Amanda Sparkes,Patrick De Baetselier,Kim Roelants et al.
Amanda Sparkes et al.
Macrophage migration inhibitory factor (MIF) was first described as a cytokine 50 years ago, and emerged in mammals as a pleiotropic protein with pro-inflammatory, chemotactic, and growth-promoting activities. In addition, MIF has gained su...
Marzena Lenart,Magdalena Rutkowska-Zapała,Rafał Szatanek et al.
Marzena Lenart et al.
Tripartite motif-containing protein 21 (TRIM21) play a dual role in the cytoplasm of the cells where it facilitates destruction of some antibody-coated viruses and some bacteria, and initiates synthesis of proinflammatory cytokines. Macroph...
Regulatory T cells in malignant pleural effusions subsequent to lung carcinoma and their impact on the course of the disease [0.03%]
肺癌后恶性胸腔积液中的调节性T细胞及其对疾病进程的影响
J Budna,Ł Spychalski,M Kaczmarek et al.
J Budna et al.
Tumors exert suppressive effects on the host immune system and tumor progression can be linked to functional impairments of immune cells. Regulatory T cells (Treg) are a subpopulation of T lymphocytes and play a key role in suppressing immu...
Van-Chien Bui,Thi-Huong Nguyen
Van-Chien Bui
Knowledge about the mechanism by which some antibodies can block HIV-1 entry is critical to our understanding of their function and may offer new avenues for controlling the adhesion of HIV-1 to the host cells. While much progress has been ...
Psoriatic inflammation causes hepatic inflammation with concomitant dysregulation in hepatic metabolism via IL-17A/IL-17 receptor signaling in a murine model [0.03%]
银屑病炎症通过IL-17A/IL-17受体信号转导在小鼠模型中诱导肝脏炎症和代谢失调
Naif O Al-Harbi,Ahmed Nadeem,Mohammed M Al-Harbi et al.
Naif O Al-Harbi et al.
Psoriatic inflammation has been shown to be associated with cardiovascular dysfunction and systemic inflammation. Recently, psoriasis has also been linked to hepatic disorders, however underlying mechanism connecting the two are unknown. IL...
Down-regulation of Na+/H+ exchanger 1 by Toll-like receptor stimulation in macrophages [0.03%]
toll-like受体刺激下调巨噬细胞中的na+/h+交换器1
Shiho Takakuwa,Natsumi Mizuno,Takayuki Takano et al.
Shiho Takakuwa et al.
The role of Na+/H+ exchanger 1 (NHE1) in various cell types, including inflammatory cells, has been extensively studied. However, regulation of NHE1 protein level in activated inflammatory cells is yet to be characterized. In this study, we...
Complement activation, inflammation and relative ADAMTS13 deficiency in secondary thrombotic microangiopathies [0.03%]
补体激活、炎症和继发性血栓性微血管病的相对ADAMTS13缺乏
Péter Farkas,Dorottya Csuka,Bálint Mikes et al.
Péter Farkas et al.
Background: The secondary forms of hemolytic uremic syndrome/thrombotic thrombocytopenic purpura (secondary TMA) emerge as complications of coexisting diseases. ...
Resveratrol improves treatment outcome and laboratory parameters in patients with Takayasu arteritis: A randomized double-blind and placebo-controlled trial [0.03%]
白藜芦醇可改善巨细胞动脉炎(TAK)患者的治疗效果和实验室检查结果：一项随机双盲安慰剂对照试验
Guoxun Shi,Minhui Hua,Qiangwei Xu et al.
Guoxun Shi et al.
Tumor necrosis factor (TNF) inhibitors have exhibited certain clinical efficacy in treating refractory Takayasu arteritis (TA), albeit with severe adverse effects. We aimed to explore the anti-TNF function of resveratrol, a natural compound...
Clinical Trial
Immunobiology. 2017 Feb;222(2):164-168. DOI:10.1016/j.imbio.2016.10.008 2017
In vivo anti-inflammatory activities of novel cytokine IL-38 in Murphy Roths Large (MRL)/lpr mice [0.03%]
新型细胞因子IL-38在Murphy Roths Large (MRL)/lpr小鼠体内的抗炎活性
Man Chu,Lai Shan Tam,Jing Zhu et al.
Man Chu et al.
The newly named interleukin (IL)-36 subfamily member IL-38 has been shown to exert anti-inflammatory activity. However, the in vivo immunomodulatory activity of IL-38 was poorly investigated in systemic lupus erythematosus (SLE). We have in...
Cigarette smoking represses expression of cytokine IL-12 and its regulator miR-21-An observational study in patients with coronary artery disease [0.03%]
吸烟通过下调细胞因子IL-12及其调节microRNA-21影响冠心病患者的免疫功能临床研究
T B Opstad,B S Brusletto,H Arnesen et al.
T B Opstad et al.
Rationale: The heterodimer IL-12 is an inducer of Th1 responses and stimulates INFƴ production. Micro-RNA-21 (miR-21) is described as a key regulator of the pro-inflammatory response and has IL-12p35 mRNA as one of its m...
Observational Study
Immunobiology. 2017 Feb;222(2):169-175. DOI:10.1016/j.imbio.2016.10.007 2017