Giuseppe Fabio Parisi,Maria Papale,Novella Rotolo et al.
Giuseppe Fabio Parisi et al.
Fecal calprotectin (FC) is used to asses the presence of intestinal inflammation also in patients with Cystic Fibrosis (CF) and recent studies showed a correlation between bowel and lung disease in these patients. The aim of this study was ...
Jaime Zamora-Chimal,Joselín Hernández-Ruiz,Ingeborg Becker
Jaime Zamora-Chimal
The role of NKT cells in the resistance or susceptibility towards Leishmania infections remains to be defined, since controversial data persist. The response of these cells seems to depend on many variables such as the infection site, the n...
Curdlan induces selective mast cell degranulation without concomitant release of LTC4, IL-6 or CCL2 [0.03%]
凝乳素诱导选择性肥大细胞脱颗粒而不伴随释放LTC4、IL-6或CCL2
Valéria C Barbosa-Lorenzi,Simon Peyda,Annika Scheynius et al.
Valéria C Barbosa-Lorenzi et al.
Mast cells are sentinel cells with a tissue-specific localization in the interface between the host and the external environment. Their quick and selective response upon encountering pathogens is part of the innate host response and typical...
Kinetic analysis of changes in T- and B-lymphocytes after anti-CD20 treatment in renal pathology [0.03%]
抗CD20治疗后肾病患者T淋巴细胞和B淋巴细胞的动态变化分析
Alexis Sentís,Fritz Diekmann,Arturo Llobell et al.
Alexis Sentís et al.
Introduction: The main objective of this study is to describe qualitatively and quantitatively the different immune lymphocyte phenotypes of patients with renal disease after treatment with anti-CD20. ...
Intratumoral heterogeneity of macrophages and fibroblasts in breast cancer is associated with the morphological diversity of tumor cells and contributes to lymph node metastasis [0.03%]
乳腺癌内的巨噬细胞和成纤维细胞的异质性与肿瘤细胞形态多样性相关并促淋巴结转移
Lubov A Tashireva,Evgeny V Denisov,Tatiana S Gerashchenko et al.
Lubov A Tashireva et al.
Recent studies have highlighted the heterogeneity of the tumor microenvironment (ME) and the importance of its analysis to the understanding of its impact on clinical outcomes. In this study, we aimed to analyze the intratumoral distributio...
Negative regulation of NLRP3 inflammasome by SIRT1 in vascular endothelial cells [0.03%]
SIRT1对血管内皮细胞NLRP3炎性小体的负向调控作用
Yanxiang Li,Xiaofeng Yang,Yanhao He et al.
Yanxiang Li et al.
NLRP3 inflammasome not only functions as a critical effector in innate immunity, but also triggers the production of proinflammatory cytokines involved in inflammation-associated diseases. Sirtuin 1 (SIRT1) plays an important role in the re...
Comparative analysis of the internalization of the macrophage receptor sialoadhesin in human and mouse primary macrophages and cell lines [0.03%]
人和小鼠原代巨噬细胞及细胞系中巨噬细胞受体唾液酸粘附素内化的比较分析研究
Marjorie De Schryver,Annelies Leemans,Isabel Pintelon et al.
Marjorie De Schryver et al.
Sialoadhesin (Sn) is a surface receptor expressed on resident macrophages with the ability to bind with sialic acids. During inflammation, an upregulation of Sn is observed. Upon binding of monoclonal antibodies to Sn, the receptor becomes ...
Comparative Study
Immunobiology. 2017 Jun;222(6):797-806. DOI:10.1016/j.imbio.2016.11.013 2017
Esther Heideveld,Emile van den Akker
Esther Heideveld
Tissue resident macrophages are found in various tissues like Langerhans cells in the skin or alveolar macrophages in the lung, and their main function is to regulate organ homeostasis. They have also been observed in the bone marrow and th...
Structural evaluation of a nanobody targeting complement receptor Vsig4 and its cross reactivity [0.03%]
针对补体受体Vsig4的纳米抗体的结构评价及其交叉反应性分析
Yurong Wen,Zhenlin Ouyang,Steve Schoonooghe et al.
Yurong Wen et al.
Vsig4 is a recently identified immune regulatory protein related to the B7 family with dual functionality: a negative regulator of T cell activation and a receptor for the complement components C3b and C3c. Here we present a structural eval...
Differences in the modulation of reactive species, lipid bodies, cyclooxygenase-2, 5-lipoxygenase and PPAR-γ in cerebral malaria-susceptible and resistant mice [0.03%]
在对脑型疟疾敏感和有抗性的鼠类体内调节活化物质、脂滴体、环氧化酶-2、白三烯加氧酶及PPAR-γ的差异性研究
Tatiana K S Borges,Érica A R Alves,Henda A R Vasconcelos et al.
Tatiana K S Borges et al.
Proinflammatory responses are associated with the severity of cerebral malaria. NO, H2O2, eicosanoid and PPAR-γ are involved in proinflammatory responses, but regulation of these factors is unclear in malaria. This work aimed to compare th...