Il-10 deficient mice express IFN-γ mRNA and clear Leptospira interrogans from their kidneys more rapidly than normal C57BL/6 mice [0.03%]
缺乏IL-10的鼠表达IFN-γ信使核糖核酸的速度比正常的C57BL/6小鼠更快并且清除致病钩端螺旋体素的速度也比正常小鼠快
Amy A Devlin,Priya J Halvorsen,Jennifer C Miller et al.
Amy A Devlin et al.
Leptospira interrogans (L. interrogans), the causative agent of leptospirosis, is a widespread zoonotic spirochete that lives a dual lifestyle. L. interrogans infects mice, rats, and wildlife in a persistent and asymptomatic fashion, while ...
TNFα-induced downregulation of microRNA-186 contributes to apoptosis in rat primary cardiomyocytes [0.03%]
肿瘤坏死因子α诱导的微小核糖核酸-186下调导致大鼠原代心肌细胞凋亡
Hua Xu,Jingyao Li,Yue Zhao et al.
Hua Xu et al.
Progressive loss of cardiac cardiomyocytes is involved in pathogenesis of heart failure. Inflammation is considered as a major risk factor that triggers cardiomyocytes apoptosis or induces cellular damage. Proinflammatory cytokines such as ...
Crosstalk between glucocorticoids and IL-4 modulates Ym1 expression in alternatively activated myeloid cells [0.03%]
糖皮质激素和IL-4的相互作用调节可极化髓系细胞YM1表达
Nathalie Ng Kuet Leong,Frank Brombacher,Alexander H Dalpke et al.
Nathalie Ng Kuet Leong et al.
Airway epithelial cells induce a tolerogenic microenvironment by modulating immune cells in the lung. We recently showed that the supernatant of airway epithelial cells induces two marker genes of alternative activation, Ym1 and Ms4a8a, in ...
The roles of a ribosomal protein S19 polymer in a mouse model of carrageenan-induced acute pleurisy [0.03%]
链菜胶诱导的小鼠急性胸膜炎模型中r蛋白s19聚合物的作用
Koji Yamanegi,Toru Kawakami,Naoko Yamada et al.
Koji Yamanegi et al.
C5-deficient mice usually present moderate neutrophil activation during the initiation phase of acute inflammation. Conversely, C5a receptor (C5aR)-deficient mice show unusually excessive activation of neutrophils. We identified the ribosom...
Molecular identification and functional characterization of a tumor necrosis factor (TNF) gene in Crassostrea hongkongensis [0.03%]
分子识别及肿瘤坏死因子(TNF)基因的功能表征在香港牡蛎中的鉴定
Fufa Qu,Zhiming Xiang,Yang Zhang et al.
Fufa Qu et al.
Tumor necrosis factor superfamily (TNFSF) represents a group of multifunctional inflammatory cytokines that have been shown to participate in a variety of pathological and immunological process. However, the functions of these proteins in o...
Enhanced immune response to a dual-promoter anti-caries DNA vaccine orally delivered by attenuated Salmonella typhimurium [0.03%]
减毒鼠伤寒沙门氏菌口服递呈的双启动子抗龋DNA疫苗诱导增强的免疫应答
Hao Jiang,Yijun Hu,Mei Yang et al.
Hao Jiang et al.
The strength of immune responses induced by DNA vaccine is closely associated with the expression level of cloned antigens available to the antigen presenting cells (APCs). To acquire a larger and more persistent amount of antigen, a dual-p...
Emerging food allergens: Identification of polyphenol oxidase as an important allergen in eggplant (Solanum melongena L.) [0.03%]
新兴的食物过敏原：鉴定出多酚氧化酶是茄子（Solanum melongena L.）中的一个重要的过敏原
Bheemanapalli N Harish Babu,Anthony Wilfred,Yeldur P Venkatesh
Bheemanapalli N Harish Babu
Although many allergens have been detected in eggplant (Solanum melongena L.), their identity have not been elucidated. The aim of this study was to investigate whether polyphenol oxidase (PPO), an important eggplant enzyme, acts as an alle...
Induction of B7-H1 receptor by bacterial cells fractions of Porphyromonas gingivalis on human oral epithelial cells: B7-H1 induction by Porphyromonas gingivalis fractions [0.03%]
牙龈卟啉单胞菌细胞裂解物诱导口腔上皮细胞表达B7-H1分子研究
S Groeger,F Jarzina,U Mamat et al.
S Groeger et al.
The immune-regulatory B7-H1 receptor, also known as programmed death-ligand 1 (PD-L1), plays an important role in cell-mediated immune response. It is a co-signaling molecule that mediates regulation of T cell activation and tolerance and i...
Giorgio Ciprandi,Paola Comite,Marco Bruzzone et al.
Giorgio Ciprandi et al.
The present study tested the hypothesis that a pan-allergen sensitization may affect the sensitization pattern. For this reason, 22 sensitization pattern allergens (SPA), common in Genoa (Italy), were selected for analyses. Successively, fi...
Robust 8-color flow cytometry panel reveals enhanced effector function of NKG2C+ CD57+ FcεRγ- NK cells in CMV seropositive human blood donors [0.03%]
一项稳健的八色流式细胞仪测定法揭示了CMV阳性人体血液供者中的NKG2C+CD57+FcεRγ- NK细胞的功能增强现象
Thomas Nerreter,Stephan Zeiß,Thomas Herrmann et al.
Thomas Nerreter et al.
Increasing evidence suggests that human NK cells may develop memory-like features. Here, we report the establishment of a robust 8-color flow cytometry panel that allows quantification and functional analysis of different memory-like NK cel...