Immunophenotypic characteristics of Langhans giant cells and the role of CCR7 in their formation [0.03%]
朗格汉斯巨细胞的免疫表型特征及其CCR7在巨细胞形成中的作用
Yumeng Jiang,Yanqing Chen,Gai Ge et al.
Yumeng Jiang et al.
Langhans giant cells (LGCs) play a crucial role in granulomatous diseases, yet their unique molecular characteristics and formation mechanisms remain unclear. In this study, we aimed to systematically characterize the molecular features of ...
Mitochondrial RNA/RIG-I promotes Caspase-1/GSDMD-mediated inflammation in sepsis-associated acute kidney injury [0.03%]
线粒体RNA/RIG-I促进脓毒症相关急性肾损伤中的Caspase-1/GSDMD介导的炎症反应
Jie Jiao,Xuan Fang,Lisha Ma et al.
Jie Jiao et al.
Mitochondria play a decisive role in the pathological mechanisms of acute kidney injury (AKI). However, the specific mechanisms by which mitochondria regulate inflammation in AKI remain elusive. We aimed to investigate the role of mitochond...
Integrated transcriptomic, metabolomic, and lipidomic analyses reveal a unique lipid profile of regulatory T cells upon activation [0.03%]
整合转录组、代谢组和脂质组分析揭示激活后调节性T细胞独特的脂质特征
Yohei Sato,Misa Yura,Alana Chandler et al.
Yohei Sato et al.
Regulatory T cells (Tregs) exhibit stable FOXP3 expression and regulate the immune response through suppressive activity. Their unique metabolic properties include increased glycolysis and oxidative phosphorylation. We combined transcriptom...
Phellodendrine chloride alleviates gouty arthritis through IL-6/STAT3 signaling pathway [0.03%]
黄柏酮氯化物通过IL-6/STAT3信号途径缓解痛风性关节炎
Yu-Yao Qin,Zi-Yi Qin,Tao Liang et al.
Yu-Yao Qin et al.
Background: Phellodendrine, a primary bioactive constituent of Phellodendron chinense Schneid (PCS), is crucial in its pharmacological profile. Phellodendrine exhibits potent anti-nephritic properties and demonstrates a m...
Rafael Almeida Paiva,Marion Salou
Rafael Almeida Paiva
Mucosal-associated invariant T (MAIT) and invariant natural killer T (iNKT) are innate-like T cells, which develop in the thymus through an original developmental program leading to the acquisition of effector memory and tissue targeting ph...
Expression of miR-146a in Th17 cells from rheumatoid arthritis patients and its correlation with inflammatory cytokines [0.03%]
类风湿关节炎患者Th17细胞中miR-146a的表达及其与炎症因子的相关性研究
Jinhui Tan,Linghua Tan,Hai Huang et al.
Jinhui Tan et al.
To investigate the expression of miR-146a in peripheral blood T helper 17(Th17) cells of patients with rheumatoid arthritis (RA) and its correlation with inflammatory cytokines [tumor necrosis factor-α (TNF-α), interleukin-6(IL-6) and int...
Exploring the role of diosgenin in modulating RUNX1 and HIPK2 transcription to mitigate Primary Sjögren's Syndrome [0.03%]
探究薯蓣皂苷通过调节RUNX1和HIPK2转录作用减轻原发性舍格伦综合征的研究
Yiwei Pan,Lunquan Wei,Han Liu et al.
Yiwei Pan et al.
Background: Primary Sjögren's Syndrome (pSS) is a chronic autoimmune disease characterized by inflammation of the exocrine glands, resulting in symptoms like dry mouth and eyes. Despite existing symptomatic treatments, u...
METTL3 regulates ASMCs proliferation and M2 macrophage polarization via mediating the m6A methylation of TIMMDC1 in asthma [0.03%]
METTL3通过介导TIMMDC1的m6A甲基化调节哮喘中气道平滑肌细胞增殖和M2型巨噬细胞极化
Shihao Zhang,Xiurong Wen,Lin Liu
Shihao Zhang
Background: Asthma has widespread prevalence and can affect the lives of children, adolescents, and adults. While methyltransferase-like 3 (METTL3) and translocase of inner mitochondrial membrane domain-containing protein...
Systemic lupus erythematosus as the paradigm for understanding the complex immune relationships and therapeutic opportunities for targeting complement in autoimmune diseases [0.03%]
系统性红斑狼疮作为理解自身免疫性疾病中补体治疗潜力的复杂免疫关系的典范模型
V Michael Holers
V Michael Holers
Complement therapeutics have been increasingly tested and approved for human diseases, often in orphan diseases with strong and apparently causal genetic linkage or mutation-associated features. However, the complement system has been demon...
A Tertiary lymphoid structures-based pathological score predicts survival and recurrence in colorectal Cancer patients [0.03%]
基于三级淋巴器官的病理评分可预测结直肠癌患者的生存和复发
Marion Le Rochais,Marie Morvan,Servane Bouzeloc et al.
Marion Le Rochais et al.
Background & aim: Colorectal cancer (CRC) is a major global health burden. The immune response within the tumor microenvironment (TME), especially the presence of tertiary lymphoid structures (TLS), plays a critical role ...