Amyloid β (Aβ) inhibits retinal angiogenesis in Alzheimer's disease via LncRNA-XIST/miRNA-126-5p/VEGF axis [0.03%]
APP衍生的淀粉样蛋白β通过长链非编码RNA-XIST / miR-126-5p / VEGF轴抑制阿尔茨海默病视网膜新生血管化
Bin Wang,Wenwei Li,Chaoyang Hong et al.
Bin Wang et al.
Alzheimer's disease (AD) is often accompanied by retinal lesions, in which Amyloid β (Aβ) is a key mediator. Vascular dysfunction is always associated with the malignant progression of AD, but the precise mechanisms remain poorly understo...
Emi Ito,Sho Yamasaki
Emi Ito
Mucosal-associated invariant T (MAIT) cells are one of the innate T cell subset. They are known to contribute to anti-bacterial response by recognizing bacterial components with invariant TCRs which are presented on a monomorphic antigen pr...
Low peripheral blood B lymphocyte count predicts poor outcome in patients with multiple myeloma [0.03%]
外周血B淋巴细胞计数较低提示多发性骨髓瘤患者预后较差
Yuqi Wang,Zhongxin Zheng,Qiaoxi Kang et al.
Yuqi Wang et al.
Previous evidence suggested that B lymphocytes may be involved in the progression and prognosis of multiple myeloma (MM). However, the prognostic value of peripheral B lymphocyte counts on MM before and after treatment in the novel agent er...
B lymphocytes impair osteogenesis by inhibiting BMSC differentiation in osteoporosis [0.03%]
B淋巴细胞通过抑制骨髓间充质干细胞分化从而损伤成骨细胞导致骨质疏松症
Cong Peng,Qiao Yang,Linyu Li et al.
Cong Peng et al.
Background: B lymphocytes have been implicated in the inhibition of osteogenesis, but their role in osteoporosis (OP) remains unclear. This study investigates the association between B lymphocytes and impaired osteogenesi...
Liyan Kaiyin Formula relieves reflux pharyngitis by regulating M1 macrophage polarization via the NF-κB/NLRP3 pathway [0.03%]
黎苈咳音方通过调控NF-κB/NLRP3信号通路模式化M1型巨噬细胞治疗喉反流性咽炎的作用研究
Lirong Wang,Xuqing Chen,Tianyu Xu et al.
Lirong Wang et al.
Background: We aimed to investigate whether Liyan Kaiyin Formula (LYKYF) can relieve reflux pharyngitis in rats by regulating M1 macrophage polarization via the nuclear factor-κB (NF-κB)/Nod-like receptor protein 3 (NLR...
Wei Hou,Tengxiao Liang,Fangliang Xing et al.
Wei Hou et al.
Background: Hepatitis B Cirrhosis, a severe progression of chronic Hepatitis B infection, requires a comprehensive understanding of the interplay among lymphocyte populations. This study aims to quantify and visualize the...
Exploring GIPC2 as a key prognostic marker in colorectal cancer linked to enhanced immune response [0.03%]
探究GIPC2作为结直肠癌预后标记物及其与增强免疫反应相关的机制
Jiaoyang Gu,Xing Qi,Bin Yu et al.
Jiaoyang Gu et al.
Background: Emerging evidence indicates a potential association between aberrant expression of GIPC PDZ Domain Containing Family member 2 (GIPC2) and the progression of colorectal cancer (CRC). However, the detailed chara...
Modulation of cytokine expression by E. coli Nissle 1917 and its OMV in intestinal epithelial cell line HT-29 [0.03%]
大肠杆菌Nissle 1917菌株及其囊膜对肠上皮细胞系HT-29中细胞因子表达的调节作用
Seyed Amir Hossein Hamidzadeh,Asal Katebi,Leila Hatami-Giklou Jajan et al.
Seyed Amir Hossein Hamidzadeh et al.
Inflammatory bowel disease (IBD) is a chronic disease recognized as an autoimmune disorder. The purpose of this is to determine the impact of the E. coli strain Nissle 1917 (EcN) and its outer membrane vesicles (OMVs) on cytokine gene expre...
Advanced glycation end products induce autophagy in endothelial cells through oxidative stress and regulation of the RhoA-mTOR signaling pathway [0.03%]
晚期糖基化终末产物通过氧化应激和RhoA-mTOR信号转导调节诱导内皮细胞自噬
Yan-Zhen Li,Fu-Qiu Liang,Shi-Zhu Lin et al.
Yan-Zhen Li et al.
Background: Advanced glycation end product (AGE)-induced oxidative stress in human umbilical vein endothelial cells (HUVECs) is closely associated with the miR-200b-RhoA signaling axis. Rho-associated protein kinase (RhoA...
Wioleta M Zelek,Andrea J Tenner
Wioleta M Zelek
Neurodegenerative diseases (NDDs) such as Alzheimer's, Parkinson's, and amyotrophic lateral sclerosis pose considerable therapeutic challenges, not only due to their complex pathophysiology, but also because any effective drug must be capab...