Proportional and functional anomalies of CD38+ NK Cells:A new mechanism for impaired anti-tumour immunity in multiple myeloma? [0.03%]
CD38+NK细胞的比例和功能异常:多发性骨髓瘤中受损的抗肿瘤免疫的新机制？
Huixian Chen,Kehua Fang,Jinbao Zong et al.
Huixian Chen et al.
Background: The abnormal quantity and dysfunction of immune cells in patients with multiple myeloma impede anti-tumour immunity and prompt the occurrence and development of disease. It has been reported that CD38+ NK cell...
Prior appendectomy attenuates the immune protective efficacy of BCG vaccination against Mycobacterium tuberculosis infection [0.03%]
阑尾切除术会降低卡介苗对肺结核感染的免疫保护作用
Huirong Huang,Wei Xu,Sidong Xiong
Huirong Huang
Cecal appendix is a unique niche for commensal bacteria, and has been considered the primary site for immunoglobulin A production. Yet its immune function in anti-infection immunity has not been fully understood. In order to elucidate wheth...
Serological assessment of rubella immunity in Iranian children post 2019 elimination: A pilot study [0.03%]
伊朗儿童麻疹免疫血清学评估：2019年后试点研究
Tasnim Jamalvandi,Akram Sadat Ahmadi,Somayeh Shatizadeh Malekshahi et al.
Tasnim Jamalvandi et al.
Background and aim: The elimination of rubella in Iran, achieved in 2019, represents a significant public health success. A limited number of studies have investigated rubella IgG seropositivity levels in Iran across diff...
Serum LINC01278 serves as a negative biomarker for sepsis and its up-regulation inhibits LPS-induced inflammatory response in THP-1 cells [0.03%]
血清LINC01278作为败血症的负性生物标志物及其上调抑制LPS诱导的炎症反应
Ying Gu,Honggang Jia,Xinyu Lin et al.
Ying Gu et al.
Background: Sepsis represents a potentially fatal condition characterized by organ failure. Long non-coding RNAs (lncRNAs) have provided new insights into the treatment of inflammation caused by sepsis. ...
Clinical significance of serum miR-98-5p in children with Mycoplasma pneumoniae infection complicated with digestive system damage [0.03%]
支原体肺炎合并消化系统损伤患儿血清miR-98-5p的临床意义
Ying Li,Wei Jia,Jiayang Huang et al.
Ying Li et al.
Background: Studies have shown that serum microRNA detection holds significant potential in improving the diagnostic accuracy of mycoplasma pneumoniae pneumonia (MPP). ...
LINC00461 promotes macrophage M1 polarization by inhibiting KLF4 transcription [0.03%]
LINC00461通过抑制KLF4转录促进M1极化
Bicong Gao,Kaitong Jia,You Ya et al.
Bicong Gao et al.
Background: Macrophage polarization is a complex process whereby macrophages differentiate into M1 (pro-inflammatory) or M2 (anti-inflammatory) phenotypes, mediating distinct and often opposing functions in immunity and t...
Untargeted metabolomics reveals postoperative metabolic dynamics in hepatic cystic echinococcosis patients [0.03%]
非目标代谢组学揭示肝棘球蚴病囊肿患者术后代谢动态变化
Kahaer Tuerxun,Abudouxikuer Abudoumijiti,Zainuer Yusupu et al.
Kahaer Tuerxun et al.
Background: Hepatic cystic echinococcosis (CE) is a chronic parasitic disease caused by the larval stage of Echinococcus granulosus and remains a significant global zoonosis, particularly in pastoral regions of northwest ...
Exosomes derived from baicalin-pretreated bone marrow mesenchymal stem cells inactivate the TLR4/MyD88/NF-kB pathway to improve asthma [0.03%]
黄芩素预处理骨髓间充质干细胞源外泌体通过抑制TLR4/MyD88/NF-κB信号通路改善哮喘病理症状
Wenbo Shen,Wei Jia,Qiang Wu et al.
Wenbo Shen et al.
Background: Baicalin, a natural compound isolated from the root of Scutellaria baicalensis Georgi, has been shown to have various pharmacological effects on lung diseases including asthma. Recently, research has suggested...
Genetic variants in complement-related genes: potential implications for cancer risk and progression [0.03%]
补体相关基因的遗传变异与癌症风险和进展的关系
Jenny N Fung,Ruben Pio
Jenny N Fung
The complement system is a critical component of the immune system, playing a significant role in pathogen defense and immune regulation. In cancer, it has a complex and dual role, either aiding in immune surveillance or contributing to tum...
Kasumi-1 exosome plays a major T-cell immune evasion role in TP53-type acute leukemia [0.03%]
Kasumi-1外泌体在TP53型急性白血病中发挥主要的T细胞免疫逃逸作用
Yunyun Du,Zhenfeng Fan,Lijiao Li et al.
Yunyun Du et al.
Background: The treatment and prognosis for TP53-mutant acute leukemia (AL) are notably unfavorable. Tumor-derived exosomes are participating in tumorigenesis and immunomodulation. Our objective was to characterize the ex...