The anti-tumor and immunomodulatory effect of α-tocopherol on tumor microenvironment in an in vitro model of colon cancer [0.03%]
α-维生素E对体外结肠癌肿瘤微环境的抗肿瘤和免疫调节作用
Tahereh Azari,Fatemeh Sadeghi,Kosar Malekpour et al.
Tahereh Azari et al.
Background: Colorectal cancer (CRC) requires effective preventive measures due to its high prevalence, mortality rate, and impact on patients' lives. Therefore, this study aimed to assess the immunomodulatory effects of ...
Role of IL33/HIF1α/VEGF in intermittent hypoxia-induced lung injury [0.03%]
间断性缺氧致肺损伤的IL33/HIF1α/VEGF轴作用机制研究
Yan Zhang,Wen-Yan Yu,Zhi-Xing Ma et al.
Yan Zhang et al.
Objective: To investigate the role of IL33/HIF1α/VEGF in lung tissue injury caused by intermittent hypoxia (IH) model in mice, and to reveal its possible mechanisms. ...
Predictive value of NKG2A+ NK cell population in diagnosing severe COVID-19 patients [0.03%]
NKG2A+NK细胞群预测严重新冠肺炎患者的价值研究
Chunqiu Yang,Rui Qian,Mengtao Gong et al.
Chunqiu Yang et al.
Objectives: To evaluate the predictive value of NKG2A+ natural killer (NK) cells in identifying patients at risk of developing severe COVID-19 and assess the therapeutic potential of NKG2A blockade in restoring NK cell an...
Dual-phase study of CD4+CXCR4+ T cells in Mycoplasma pneumoniae pneumonia: clinical correlations in children and therapeutic exploration with tofacitinib in mice [0.03%]
人型支原体肺炎CD4+CXCR4+T细胞的双相研究：儿童临床相关性及小鼠模型中的托法替尼治疗探索
Kaiwen Wang,Li Guo,Yongqi Zhang et al.
Kaiwen Wang et al.
Objective: This study had two primary objectives. First, we aimed to investigate whether differential expression of the chemokine receptor CXCR4 on CD4+ T lymphocytes could serve as a distinguishing immunological feature ...
A A Nowacka,L Sordo Vieira,V Petr et al.
A A Nowacka et al.
Infectious diseases remain a significant cause of mortality and morbidity worldwide. Complement is a critical component in the defense against pathogens and despite their great differences, viruses, bacteria, fungi, and protists have all de...
Complement proteins changes in ischemic stroke patients and their relation to outcome [0.03%]
缺血性卒中患者的补体成分改变及其与预后的关系
Radosław Opiła,Karolina Łuczkowska,Edyta Paczkowska et al.
Radosław Opiła et al.
We studied plasma levels of complement system factors C1q, C2, C3, C3b, C4, C4b, C5, C5a, C9 of 84 patients with ischemic stroke within 24 h from onset of symptoms and on seventh day after admission, using Luminex immunoassay. C1q, C2, C3, ...
The impact of neutralizing anti-IFN-γ autoantibodies on GBP5 expression and monocyte dysfunction in adult-onset immunodeficiency [0.03%]
中和性抗干扰素-y自身抗体对成人免疫缺陷患者GBP5表达及单核细胞功能障碍的影响
Kanokporn Sornsuwan,On-Anong Juntit,Kanyarat Thongheang et al.
Kanokporn Sornsuwan et al.
Anti-interferon gamma (IFN-γ) autoantibodies (AIGAs) are linked to opportunistic infections in adult-onset immunodeficiency (AOID). These autoantibodies, particularly those recognizing the C-terminal linear epitope (P128-143) and B27 epito...
Programmed cell death ligand 1 mediates antigen presentation, apoptosis, necrosis, and inflammatory response in Klebsiella pneumoniae-infected macrophages [0.03%]
肺炎克雷伯菌感染的巨噬细胞中程序性死亡配体1介导抗原呈递、凋亡、坏死和炎症反应
Xiaoya Zheng,Weihong Tang,Qiaoqiao Tang et al.
Xiaoya Zheng et al.
Klebsiella pneumoniae (Kp) infection has high global complication and mortality rate. Programmed cell death ligand 1 (PD-L1) is important for immune evasion in tumorigenesis, however, with unclear mechanism in Kp infection. This study aims ...
Anti-retroviral treatment of HIV infected individuals improves the ex vivo generation of memory-like NK cells [0.03%]
抗逆转录病毒治疗可通过体外生成类似记忆NK细胞改善HIV感染患者体内情况
Kalavati Lalsare,Shubhangi Bichare,Sheetal Mulay et al.
Kalavati Lalsare et al.
The ability of Natural Killer (NK) cells, to generate memory-like responses against viruses including - HIV, opened up possibility of their application as immune therapy. We attempted to generate memory-like NK cells from HIV exposed and un...
The Impacts of Acute High-Level Gamma Radiation Exposure on immunological parameters in the blood of rats [0.03%]
高剂量γ射线急性照射对大鼠外周血免疫学参数的影响研究
Soha M Hussien
Soha M Hussien
Gamma radiation (γR) influences cytokine regulation, with high doses (HD) producing marked biological effects under both controlled and accidental exposure scenarios. This study investigates the immunological responses to γR at doses of 2...