Anti-inflammatory activity of calmodulin-lysine N-methyltransferase through suppressing the caspase-11 non-canonical inflammasome [0.03%]
钙调素赖氨酸N-甲基转移酶通过抑制caspase-11非经典炎性小体发挥抗炎作用
Hui-Jin Cho,Dong Joon Lee,Young-Su Yi
Hui-Jin Cho
Calmodulin (CaM)-lysine N-methyltransferase (CAMKMT) is a novel methyltransferase that catalyzes lysine trimethylation in CaM. However, its specific roles in inflammatory responses and diseases remain unclear. In this study, we investigated...
IL-27p28 specifically regulates MHC II expression in macrophages through CIITA [0.03%]
白细胞介素-27特异性地通过CIITA调节巨噬细胞MHCⅡ类分子的表达
Yu Han,Xu Zhang,Qing Wang et al.
Yu Han et al.
Antigen-presenting cells (APCs) constantly express major histocompatibility complex II (MHC II), including macrophages and dendritic cells (DCs) which deliver antigens to CD4+ T cells and play an important role in adaptive immunity. The exp...
The signature and predictive value of immune parameters in patients with secondary hemophagocytic lymphohistiocytosis [0.03%]
继发性噬血细胞综合征患者免疫参数的特征及预后价值分析
Huan Bai,Yun Wang,Ling Shen et al.
Huan Bai et al.
Background: Secondary hemophagocytic lymphohistiocytosis (sHLH) is a rare but fatal clinical syndrome, characterized by severe immune dysfunction and overwhelming inflammatory response. However, the host immune signature ...
Identification of hub biomarkers and immune-related pathways participating in the progression of Kawasaki disease by integrated bioinformatics analysis [0.03%]
整合生物信息学分析识别川崎病进展中参与的核心生物标志物和免疫相关通路
Yang Gao,Xuan Tang,Guanghui Qian et al.
Yang Gao et al.
Background: Kawasaki disease (KD) is a systemic vasculitis that commonly affects children and its etiology remains unknown. Growing evidence suggests that immune-mediated inflammation and immune cells in the peripheral bl...
Evaluation of the anti-inflammatory effects of PI3Kδ/γ inhibitors for treating acute lung injury [0.03%]
PI3Kδ/γ抑制剂抗炎作用评估及其治疗急性肺损伤的效果研究
Wendian Xiong,Lei Jia,Yanfei Cai et al.
Wendian Xiong et al.
Phosphatidylinositol 3-kinase delta (PI3Kδ) and gamma (PI3Kγ) are predominantly located in immune and hematopoietic cells. It is well-established that PI3Kδ/γ plays important roles in the immune system and participates in inflammation; ...
Study of tissue transglutaminase spliced variants expressed in THP-1 derived macrophages exhibiting distinct functional phenotypes [0.03%]
研究THP-1来源、具有不同功能表型的巨噬细胞中表达的组织转谷氨酰胺酶剪接变体
Paula Arbildi,Federico Calvo,Victoria Macías et al.
Paula Arbildi et al.
Tissue transglutaminase (TG2) expressed in monocytes and macrophage is known to participate in processes during either early and resolution stages of inflammation. The alternative splicing of tissue transglutaminase gene is a mechanism that...
The role of T cells and shared genes in psoriasis and inflammatory bowel disease based on single-cell RNA and comprehensive analysis [0.03%]
基于单细胞RNA和全面分析的银屑病与炎症性肠病中T细胞和共有基因的作用
Xiaofeng Liang,Zhishen Peng,Ying Deng et al.
Xiaofeng Liang et al.
Psoriasis and inflammatory bowel disease (IBD) have a similar etiology, including abnormal activation of T cells. Differentially expressed genes (DEGs) analysis was used to search for shared genes. GO (Gene Ontology) and KEGG (Kyoto Encyclo...
Alterations in Helios+ T cell subsets in peripheral blood of early-stage lung adenocarcinoma patients: Implications for early diagnosis [0.03%]
外周血日神型T细胞亚群在早期肺腺癌患者中的改变及其诊断价值探索
Yiming Zhao,Ming Zhao,Meng Li et al.
Yiming Zhao et al.
Objective: This study aimed to investigate the changes and significance of circulating Helios-associated T cell subsets in patients with early-stage lung adenocarcinoma (LUAD). ...
Cafeteria diet-induced obesity remodels immune response in acute Trypanosoma cruzi infection [0.03%]
西餐引起的肥胖会重塑急性克氏锥虫感染中的免疫反应
Amanda Goulart,Naira Ferreira Anchieta,Pedro Alexandre Sampaio et al.
Amanda Goulart et al.
Background: Obesity is a global problem associated with several conditions, including hypertension, diabetes, arthritis and cardiovascular diseases. With the increase in the prevalence of obesity in recent years, mostly i...
Identification and validation of a novel NK cells-related signature to predict prognosis and immune microenvironment in LUAD [0.03%]
识别并验证一个新型天然杀伤细胞相关的特征以预测LUAD的预后和免疫微环境
Chenghu Song,Weici Liu,Guanyu Jiang et al.
Chenghu Song et al.
Background: The prevalence and fatality rates of lung cancer are experiencing a rapid escalation. Natural Killer (NK) cells have been established to have a crucial role in both tumor initiation and progression. Neverthele...