Cytokine-induced killer (CIK) cells inhibit Plasmodium falciparum parasitemia through cytolytic effector activity in vitro [0.03%]
细胞因子诱导的杀伤(CIK)细胞通过体外细胞毒性效应活性抑制恶性疟原虫寄生现象
Rohulla Vaseq,Berthila Ferkamchwi,Hans Weiher et al.
Rohulla Vaseq et al.
Cytokine-induced killer (CIK) cells, with dual traits resembling natural killer (NK) and T cells, have shown a promising clinical efficacy against cancer in clinical application leading to licensing of CIK cells in many countries. Here, we ...
Screening of kinase-related genes as diagnostic biomarkers and immune infiltration analysis in sepsis [0.03%]
脓毒症相关激酶基因的诊断标志物筛选及免疫浸润分析研究
Bingqiang Su,Yingwei Ding,Xiuqi Zhu et al.
Bingqiang Su et al.
Background: Sepsis is a systemic inflammatory syndrome that can lead to loss of organ function. Kinase-related genes (KRGs) modulate immune diseases by regulating inflammation, immune metabolism, and apoptosis. However, t...
Unraveling SLAN+/- monocytes transcriptomics in lupus and extracellular vesicles effects [0.03%]
SLAN+/-单核细胞转录组在狼疮和外泌体效应中的研究
Paula X Losada,Juan Antonio Villatoro-García,Julio Jaramillo et al.
Paula X Losada et al.
Objective: Lupus Nephritis (LN) is a common and serious complication in patients with Systemic Lupus Erythematosus (SLE), an immune complex-mediated disease. Extracellular Vesicles (EVs) can carry autoantigens recognized ...
SLAMF7 improves the efficacy of PD-1 immunotherapy by enhancing T cell response in non-small cell lung cancer [0.03%]
SLAMF7通过增强非小细胞肺癌T细胞反应来提高PD-1免疫疗法的疗效
Juanfeng Lao,Manman Zhu,Liangjian Kuang et al.
Juanfeng Lao et al.
Programmed death-1 (PD-1) immune checkpoint inhibition has transformed the therapeutic landscape of non-small cell lung cancer (NSCLC), while a proportion of NSCLC cases exhibited primary or acquired resistance, reflecting the imperative to...
MiR-210 suppresses Candida albicans-derived β-glucan-induced inflammation in THP-1-derived macrophages via the Syk-NF-κB pathway [0.03%]
MiR-210通过Syk-NF-κB途径抑制念珠菌α-葡聚糖诱导的炎症反应
Junsheng Hou,Min Li
Junsheng Hou
In immunocompromised individuals, infections due to Candida albicans (C. albicans) can be life-threatening. Recognition of the insoluble β-glucan derived from the C. albicans cell wall (CaIG) by Dectin-1 in macrophages initiates an inflamm...
Jie Gao,Zhe Li,Xinyue Zhang et al.
Jie Gao et al.
Cognitive impairment is a global health problem with increasing prevalence and mortality rates. The complement system plays a key role in the underlying pathological mechanisms. To explore potential strategies for ameliorating and preventin...
Immunometabolism of T cells and macrophages: Human translational perspectives [0.03%]
T细胞和巨噬细胞的免疫代谢：人类转化研究的观点
Borros Arneth
Borros Arneth
Background: Immunometabolism explores how immune-cell function depends on cellular energy metabolism. Recent insights demonstrate that nutrient utilization dictates activation, polarization, and tolerance. ...
Single-cell transcriptome reveals that immune cells inhibit the repairment of IGFBP3 + stromal cells in thin endometrium [0.03%]
单细胞转录组揭示免疫细胞通过抑制IGFBP3+基质细胞修复薄子宫内膜发挥作用
Haijiao Zou,Dongmei Zhou,Shaodan Fang et al.
Haijiao Zou et al.
Thin endometrium (TE), affecting 1.5 %-9.1 % of reproductive-aged women, emerges as a disturbed decidua microenvironment underpinning implantation failure and recurrent pregnancy loss. Through integrated single-cell transcriptomics with his...
ZBP1 aggravates acute lung injury in mice by promoting the macrophage inflammatory phenotype [0.03%]
缺氧诱导的巨噬细胞炎症表型促进急性肺损伤小鼠ALI恶化
Hong Li,Xiaoliang Du,Yongze Liu et al.
Hong Li et al.
Background: Acute lung injury (ALI) is an acute lung inflammatory disease that is difficult to cure and has a poor prognosis. Macrophages play a key role in the pathogenesis of ALI, and their different phenotypes and func...
Predictive value of interstitial inflammation for renal outcome in patients with immunoglobulin a nephropathy [0.03%]
免疫复合物肾小球病患者间质炎症的预后价值
Qing Wei,Min Wu,Yuxiang Gong et al.
Qing Wei et al.
Background: Renal interstitial inflammation (RII) is a common pathological feature in immunoglobulin A nephropathy (IgAN) and may predict renal outcomes, but further validation is required. This study evaluated the progno...