Increased co-expression of ICOS and PD-1 predicts poor overall survival in patients with acute myeloid leukemia [0.03%]
急性髓系白血病患者ICOS和PD-1共表达增加预示总生存率较差
Shiyi Pan,Qinghua Cai,Yiqiong Wei et al.
Shiyi Pan et al.
Background: Inducible co-stimulatory factor (ICOS) has a dual role: activating cytotoxic T cells against tumors or exacerbating immunosuppression of regulatory T cells (Tregs) to participate in immune evasion. However, th...
Alterations in the immune landscape characterized by inflammatory activation and immune escape within 12 h after trauma [0.03%]
创伤后12小时免疫图谱的改变表现为炎症激活和免疫逃逸
Chenghu Song,Weici Liu,Yu Luo et al.
Chenghu Song et al.
Background: Trauma is statistically a significant cause of mortality among patients across countries. Nevertheless, the precise correlation between genetic diagnostic markers and the intricate mechanism of trauma remains ...
Comparable cytokine release ex-vivo by whole blood from COVID-19 patients with and without non-invasive ventilation [0.03%]
新冠肺炎患者体外全血细胞因子释放的比较（有无无创通气情况）
Martina Bonacini,Ilaria Ferrigno,Alessandro Rossi et al.
Martina Bonacini et al.
T cells are key players in the resolution of the infection by SARS-CoV-2. A delay in their activation can lead to severe COVID-19. The present work aimed to identify differences in cytokine release by T cells ex-vivo between COVID-19 patien...
PSMC2 promotes glioma progression by regulating immune microenvironment and PI3K/AKT/mTOR pathway [0.03%]
PSMC2通过调节免疫微环境和PI3K/AKT/mTOR信号通路促进胶质瘤进展
Yizheng Wang,Shiyang Zhang,Zijun Zhao et al.
Yizheng Wang et al.
Background: Glioma, the most frequent and malignant central nervous system (CNS) cancer, has a bad outcome. Proteasome 26S subunit ATPase 2 (PSMC2) is an essential part of the 26S proteasome and promotes the development o...
The changes of intestinal flora and its relevance with memory Tfh and B cells in rheumatoid arthritis patients treated with csDMARDs and csDMARDs + bDMARDs [0.03%]
接受传统合成抗风湿药和生物制剂治疗的类风湿关节炎患者肠道菌群变化及其与Tfh和B细胞的关系研究
Chunlei Jiang,Shuhong Chi,Fengkui Wang et al.
Chunlei Jiang et al.
Background: A growing body of experimental and clinical evidence has implicated gut microbiota in the onset and course of rheumatoid arthritis (RA). The imbalance of intestinal flora in RA patients may lead to abnormal ex...
Effect of dapagliflozin on collectins and complement activation in plasma from patients with type 2 diabetes and albuminuria: Data from the DapKid cohort [0.03%]
达格列净对2型糖尿病伴白蛋白尿患者血浆中凝集素和补体活化的影响：DapKid队列的数据分析
Mia Jensen,Mie K Eickhoff,Frederik Persson et al.
Mia Jensen et al.
Background: Sodium-glucose cotransporter 2 (SGLT- 2) inhibitors exert cardiovascular and kidney-protective effects in people with diabetes. Attenuation of inflammation could be important for systemic protection. The lecti...
Randomized Controlled Trial
Immunobiology. 2024 May;229(3):152797. DOI:10.1016/j.imbio.2024.152797 2024
Transcription suppression of GABARAP mediated by lncRNA XIST-EZH2 interaction triggers caspase-11-dependent inflammatory injury in ulcerative colitis [0.03%]
长链非编码 RNA XIST 通过与 EZH2 相互作用抑制 GABARAP 的转录从而触发溃疡性结肠炎中依赖于半胱天冬酶 -11 的炎症损伤
Dan Gu,Ting Cao,Shijie Yi et al.
Dan Gu et al.
Background: We have previously found that enhancer of zeste homolog 2 (EZH2) is correlated with inflammatory infiltration and mucosal cell injury in ulcerative colitis (UC). This study aims to analyze the role of X-inacti...
The predictive value of miR-377 and phospholipase A2 in the early diagnosis of diabetic kidney disease and their relationship with inflammatory factors [0.03%]
miR-377和磷脂酶A2在糖尿病肾病早期诊断中的预测价值及其与炎症因子的关系
Chenhao Xing,Lijing Huo,Hongyue Tang et al.
Chenhao Xing et al.
Objective: The value of novel biomarkers for DKD has received increasing attention, and there is an urgent need for novel biomarkers with sensitivity, specificity and ability to detect kidney damage.miR-377 regulates many...
Transmission patterns of C1-INH deficiency hereditary angioedema favors a wild-type male offspring: Our experience at Chandigarh, India [0.03%]
C1-抑制剂缺乏遗传性血管性水肿的传递模式倾向于野生型男性后代：我们在印度昌迪加尔的经验
Sanghamitra Machhua,Ankur Kumar Jindal,Suprit Basu et al.
Sanghamitra Machhua et al.
Background: Deficiency of C1-inhibitor (C1-INH) protein, caused by pathogenic variants in the Serpin family G member 1 (SERPING1) gene, is the commonest pathophysiological abnormality (in ∼95 % cases) in patients with he...
The phenotype and related gene expressions of macrophages in adipose tissue of T2D mice following MSCs infusion [0.03%]
MSCs输注后T2D小鼠脂肪组织中巨噬细胞的表型及有关基因表达变化
Wanlu Su,Yaqi Yin,Yu Cheng et al.
Wanlu Su et al.
Background: Infusion of mesenchymal stem cells (MSCs) induces polarization of M2 macrophages in adipose tissue of type 2 diabetes (T2D) mice. Studies have shown that M2 macrophages were divided into four sub-phenotypes (M...