Variations in the interferon and TLR3 genes may be associated with susceptibility to systemic lupus erythematosus and its clinical presentation [0.03%]
干扰素和TLR3基因的多态性可能与系统性红斑狼疮的易感性和临床表现有关
E Modzelewska,A Wajda,A Lutkowska et al.
E Modzelewska et al.
The study aimed to explore the pontential impact of 10 polymorphisms within IFN-α, IFN-β1, IFN-γ and TLR3 genes on SLE phenotype and susceptibility and to study the relationship between specific genotypes and clinics. Whole blood samples...
Altered serum concentrations of IL-8, IL-32 and IL-10 in patients with lung impairment 6 months after COVID-19 [0.03%]
新冠后六个月肺功能不全患者的血清IL-8、IL-32 和 IL-10 浓度变化
Laura Bergantini,Sara Gangi,Miriana d&#x;Alessandro et al.
Laura Bergantini et al.
Post-COVID symptoms are reported in 10-35 % of patients not requiring hospitalization, and in up to 80 % of hospitalized patients and patients with severe disease. The pathogenesis of post-COVID syndrome remains largely unknown. Some eviden...
The involvement of oxidative stress and the TLR4/NF-κB/NLRP3 pathway in acute lung injury induced by high-altitude hypoxia [0.03%]
氧化应激及TLR4/NF-κB/NLRP3信号途径在高原低氧急性肺损伤中的作用
Wangjie Cao,Yuanding Zeng,Yun Su et al.
Wangjie Cao et al.
Objective: This study investigated the effect of oxidative stress and the TLR4/NF-κB/NLRP3 pathway on the pathogenesis of acute lung injury (ALI) induced by high-altitude hypoxia. ...
Antipyretic and anti-inflammatory effects of inosine, an active component of Kangfuxin [0.03%]
复方新博林中活性成分次黄嘌呤的解热抗炎作用研究
Yue Zhang,Daqi Jia,Yipeng Wu et al.
Yue Zhang et al.
Kangfuxin has been widely recognized for its use in treating ulcerative conditions and mucositis, primarily due to its anti-inflammatory properties, which promote cell proliferation, granulation tissue growth, and angiogenesis. However, the...
Activation of the cGAS-STING pathway by viral dsDNA leading to M1 polarization of macrophages mediates antiviral activity against hepatitis B virus [0.03%]
cGAS-STING通路通过病毒dsDNA活化导致巨噬细胞M1极化介导的抗乙肝病毒活性
Qiyin Zong,Hao Zhang,Futing Liu et al.
Qiyin Zong et al.
Background and aims: Activation of the cGAS-STING pathway induces the production of type I interferons, initiating the antiviral immune response, which contributes to the clearance of pathogens. Previous studies have show...
The safety and efficacy of tumor necrosis factor-alpha inhibitor on pregnancy outcomes in patients with unexplained recurrent miscarriage [0.03%]
肿瘤坏死因子α抑制剂对不明原因反复流产患者妊娠结局的安全性和有效性分析
Fangxiang Mu,Chen Wang,Lin Liu et al.
Fangxiang Mu et al.
Objectives: Although tumor necrosis factor-alpha inhibitor (TNFi) treatment may improve pregnancy outcomes in unexplained recurrent miscarriage (URM) patients, evidence for its efficacy and safety is still insufficient. T...
The heterogeneity of tumour-associated macrophages contributes to the clinical outcomes and indications for immune checkpoint blockade in colorectal cancer patients [0.03%]
肿瘤相关巨噬细胞的异质性对结直肠癌患者临床预后及免疫检查点抑制剂疗效的影响
Junhui Tang,Liang Ming,Feiyu Qin et al.
Junhui Tang et al.
Tumor-associated macrophages (TAMs), one of the major immune cell types in colorectal cancer (CRC) tumor microenvironment (TME), play indispensable roles in immune responses against tumor progression. In this study, we aimed to know whether...
Retraction notice to "In vitro anticholinergic drugs affect CD8+ peripheral blood T-cells apoptosis in COPD" [Immunobiology 217/3 (2012) 345-353] [0.03%]
撤销登刊文章“体外抗胆碱药物影响COPD外周血CD8+T细胞的凋亡[免疫生物学217/3(2012)345-353]"的通知
Mirella Profita,Loredana Riccobono,Angela Marina Montalbano et al.
Mirella Profita et al.
Retraction of Publication
Immunobiology. 2024 May;229(3):152800. DOI:10.1016/j.imbio.2024.152800 2024
Association of neutrophil extracellular trap levels with Raynaud's phenomenon, glomerulonephritis and disease index score in SLE patients from Brazil [0.03%]
巴西系统性红斑狼疮患者中中性粒细胞胞外陷阱水平与雷诺现象、肾小球肾炎和疾病指数评分的关系
Eduardo Delabio Auer,Valéria Bumiller-Bini Hoch,Emiliano Borges da Silva et al.
Eduardo Delabio Auer et al.
Neutrophil extracellular traps (NETs) are cell-extruded DNA strands coated with neutrophils' nuclear proteins and enzymes from cytotoxic granules, produced by NETosis, a cell death pathway. They perform an important defensive role in innate...
LncRNA SNHG1 overexpression alleviates osteoarthritis via activating PI3K/Akt signal pathway and suppressing autophagy [0.03%]
长链非编码RNA SNHG1过表达通过激活PI3K/Akt信号通路和抑制自噬来缓解骨关节炎
Qiushi Wang,Jie Yang,Rui Pan et al.
Qiushi Wang et al.
We hereby intend to further explore and confirm the underlying mechanism of Small nucleolar RNA Host Gene 1 (SNHG1) in osteoarthritis (OA). For in vitro assays, OA was induced in primary chondrocytes with interleukin-1β (IL-1β) treatment;...