Integrated machine learning screened glutamine metabolism-associated biomarker SLC1A5 to predict immunotherapy response in hepatocellular carcinoma [0.03%]
集成机器学习筛选谷氨酰胺代谢相关生物标志物SLC1A5以预测肝细胞癌免疫治疗反应
Guixiong Zhang,Yitai Xiao,Hang Liu et al.
Guixiong Zhang et al.
Hepatocellular carcinoma (HCC) stands as one of the most prevalent malignancies. While PD-1 immune checkpoint inhibitors have demonstrated promising therapeutic efficacy in HCC, not all patients exhibit a favorable response to these treatme...
Selenium nanoparticles enhance the anti-tumor immune responses of anti-4-1BB antibody and alleviate the adverse effects on mice [0.03%]
硒化银纳米粒子可增强抗4-1BB抗体的抗肿瘤免疫反应并减轻对小鼠的不良作用
Lei Zhang,Houru Liu,Jie Shen et al.
Lei Zhang et al.
4-1BB agonists for cancer immunotherapy have shown good preliminary efficacy in clinical trials, but several of the first-generation 4-1BB agonistic antibodies entering the clinic have failed due to safety issues. Selenium nanoparticles (Se...
In silico analysis of DEL-1 and inflammation-related genes in lung squamous cell carcinoma [0.03%]
DEL-1和与炎症相关的基因在肺鳞状细胞癌中的生物信息学分析
Rahsan Ilikci-Sagkan,Dilara Fatma Akin,Recep Liman et al.
Rahsan Ilikci-Sagkan et al.
Aim: Twenty to thirty percent of non-small cell lung cancers (NSCLC) are caused by lung squamous cell carcinoma (LUSC), especially in smokers and there has been limited study previously evaluating the situation in terms o...
Letícia Torres-Dias,Rebeca Santana Souza,Jessica Carolina Alves Moreira et al.
Letícia Torres-Dias et al.
It is known that conventional antigen presentation involves phagocytosis of antigens followed by its internalization in endocytic compartments and presentation of epitopes through MHC class II molecules for CD4 T cells. However, since 1976 ...
Identification of RNMT as an immunotherapeutic and prognostic biomarker: From pan-cancer analysis to lung squamous cell carcinoma validation [0.03%]
RNMT作为免疫治疗和预后生物标志物的鉴定：从泛癌分析到肺癌鳞状细胞癌验证
Shuqiang Huang,Cuiyu Tan,Jinzhen Zheng et al.
Shuqiang Huang et al.
Background: Dysregulation of RNA guanine-7 methyltransferase (RNMT) plays a crucial role in the tumor progression and immune responses. However, the detailed role of RNMT in pan-cancer is still unknown. ...
Exploring liquid-liquid phase separation-related diagnostic biomarkers in osteoarthritis based on machine learning algorithms and experiment [0.03%]
基于机器学习算法和实验探索液-液相分离相关诊断生物标志物在骨关节炎中的作用
Bo Dong,Yue Li
Bo Dong
Background: Osteoarthritis (OA) is a prevalent joint disorder characterized by cartilage degeneration and joint inflammation. Liquid-liquid phase separation (LLPS), a biophysical process involved in cellular organization,...
HNRNP I promotes IRAK1 degradation to reduce podocyte apoptosis and inflammatory response alleviating renal injury in diabetic nephropathy [0.03%]
hnRNPI通过促进IRAK1降解抑制糖尿病肾病系膜细胞凋亡及炎症反应
Zichen Rao,Geriletu Ao,Yiming Zhang et al.
Zichen Rao et al.
Podocytes maintain renal filtration integrity when the glomerular filtration barrier (GFB) is integrated. Impairment or attrition of podocytes, leading to compromised GFB permeability, constitutes the primary etiology of proteinuria and is ...
Exploring the role of pyroptosis and immune infiltration in sepsis based on bioinformatic analysis [0.03%]
基于生物信息学分析探究焦亡与免疫浸润在脓毒症中的作用
Zhi-Hua Li,Yi Wang,Xiang-You Yu
Zhi-Hua Li
Purpose: Sepsis is a disease that is typically treated in intensive care units with high mortality and morbidity. Pyroptosis is a newly identified type of programmed cell death and is characterized by inflammatory cytokin...
Chimeric antigen carried by extracellular vesicles induces stronger protective immunity against Mycobacterium tuberculosis infection [0.03%]
由细胞外囊泡携带的嵌合抗原诱导更强的保护性免疫以抵抗结核杆菌感染
Lin Ji,Yuxuan Fu,Sidong Xiong
Lin Ji
Although Bacillus Calmette-Guerin (BCG) has been used in human for centuries, tuberculosis (TB) remains one of the deadliest infectious diseases.There have been remarkable successes in the field of TB vaccine research over the past decade, ...
Chronic NOD2 stimulation by MDP confers protection against parthanatos through M2b macrophage polarization in RAW264.7 cells [0.03%]
MDP持续刺激NOD2通过RAW264.7细胞中M2b型巨噬细胞极化来抵抗PARP介导的细胞死亡(parthanatos)
Florencia C Mansilla,María C Miraglia,Silvina S Maidana et al.
Florencia C Mansilla et al.
Innate immune cells show enhanced responsiveness to secondary challenges after an initial non-related stimulation (Trained Innate Immunity, TII). Acute NOD2 activation by Muramyl-Dipeptide (MDP) promotes TII inducing the secretion of pro-in...