Clostridium butyricum attenuates LPS-induced myocardial injury in septic mice by modulating CD4 + CD25 + FOXP3 + Treg [0.03%]
芽孢杆菌通过调节CD4+CD25+FOXP3+treg减轻败血症小鼠LPS诱导的心肌损伤
Jinglin Zhao,Liuli Wu,Rupan Zhang et al.
Jinglin Zhao et al.
Sepsis-induced myocardial injury has become a major threat to patient health and safety. Intestinal microbiota imbalance plays a crucial role in sepsis regulation. Using 16srRNA technology, we explored how intestinal colonization of Clostri...
Downregulating LKB1 in bone marrow mesenchymal stem cells could inhibit CD4+ T cell proliferation via the PD-1/PD-L1 signaling pathway [0.03%]
通过PD-1/PD-L1信号通路下调骨髓间充质干细胞中的LKB1可抑制CD4⁺T细胞增殖
Yaqin Zhang,Jingyi Ren,Zhongxian Liao et al.
Yaqin Zhang et al.
Background: Our previous research has shown that LKB1 in amniotic mesenchymal stem cells (MSCs) serves as a vital regulator of regulatory T cell differentiation and T cell proliferation, which may have a similar role in b...
Pan-cancer analysis of ADAR1 with its prognostic relevance in low-grade glioma [0.03%]
ADAR1的泛癌分析及其在低级别胶质瘤预后中的相关性
Qin Yang,Xin Li
Qin Yang
ADAR1, known as the primary enzyme for adenosine-to-inosine RNA editing, has recently been implicated in cancer development through both RNA editing-dependent and -independent pathways. These discoveries suggest that ADAR1's functions may e...
The role of CD24hiCD27+ regulatory B cells in human chronic rhinosinusitis with/without nasal polyps [0.03%]
CD24hiCD27+调节性B细胞在人慢性鼻窦炎伴或不伴有鼻息肉中的作用
Shiyu Tian,Jiao Xia,Ke Liu et al.
Shiyu Tian et al.
Background: Regulatory B cells (Bregs) reduce allergic and autoimmune inflammation. However, their role in chronic rhinosinusitis (CRS) remains unknown. This study investigated the frequency and function of Breg subsets i...
Comparison of urine and serum IgG detection ELISA for tegumentary leishmaniasis diagnosis and prognosis [0.03%]
检测皮肤利什曼病诊断和预后的尿液和血清IgG的对比酶联免疫吸附试验
Raquel S B Câmara,Isabela A G Pereira,Daniela P Lage et al.
Raquel S B Câmara et al.
Laboratorial diagnosis of tegumentary leishmaniasis (TL) is hampered by variable sensitivity and/or specificity of the tests, which are still hampered by blood́ invasive collection. In this context, in the present study, we develop a serum...
Comparative Study
Immunobiology. 2024 Nov;229(6):152853. DOI:10.1016/j.imbio.2024.152853 2024
A study on the efficacy and Safety Evaluation of a novel PD-1/CTLA-4 bispecific antibody [0.03%]
一项新型PD-1/CTLA-4双特异性抗体疗效和安全性研究
Qi Song,Meiling Jiang,Xinrong Pan et al.
Qi Song et al.
Tumors constitute a significant health concern for humans, and PD-1 and CTLA-4 monoclonal antibodies have been proven effective in cancer treatment. Some researchers have identified that the combination of PD-1 and CTLA-4 dual blockade demo...
Myeloperoxidase-deficient mice exposed to Zymosan exhibit severe neutrophilia and anemia with enhanced granulopoiesis and reduced erythropoiesis, accompanied by pulmonary inflammation [0.03%]
髓过氧化物酶缺乏的小鼠暴露于zymosan后会出现严重的中性粒细胞增多和贫血，伴有增强的粒细胞生成和减少的红细胞生成以及肺部炎症
Misaki Yoshikawa,Yuki Sato,Mayu Sasaki et al.
Misaki Yoshikawa et al.
We previously reported that myeloperoxidase-deficient (MPO-/-) mice develop more severe neutrophil-rich lung inflammation than wild-type mice following intranasal Zymosan administration. Interestingly, we found that these mutant mice with s...
Identification and validation of potential biomarkers related to oxidative stress in idiopathic pulmonary fibrosis [0.03%]
特发性肺纤维化相关氧化应激潜在生物标志物的识别与验证
Xianglin Du,Zhen Ma,Yanqing Xing et al.
Xianglin Du et al.
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, fibrotic interstitial pneumonia with a poor prognosis and a pathogenesis that has not been fully elucidated. Oxidative stress is closely associated with IPF. In this research, w...
Dexmedetomidine induces IL-10 secretion by B lymphocytes in the peripheral blood of patients with hepatocellular carcinoma [0.03%]
右美托咪啶诱导肝癌患者外周血B淋巴细胞分泌IL-10
Miaomiao Qin,Yining Chen,Xinxin Wang et al.
Miaomiao Qin et al.
Background/aim: To investigate the distribution of subpopulations of peripheral blood B lymphocytes in individuals with hepatocellular carcinoma (HCC), and to evaluate the effect of dexmedetomidine (DEX) on B lymphocyte d...
TLR4/TNFR1 blockade suppresses STAT1/STAT3 expression and increases SOCS3 expression in modulation of LPS-induced macrophage responses [0.03%]
TLR4/TNFR1抑制通过调控LPS诱导的巨噬细胞反应中的STAT1/STAT3表达并增加SOCS3表达发挥功效
Ritasha Sawoo,Biswadev Bishayi
Ritasha Sawoo
Due to the urgent need to create appropriate treatment techniques, which are currently unavailable, LPS-induced sepsis has become a serious concern on a global scale. The primary active component in the pathophysiology of inflammatory disea...