LncRNA FENDRR/ miR-424-5p serves as a diagnostic biomarker for sepsis and its predictive value for clinical outcomes [0.03%]
长链非编码RNA FENDRR/miR-424-5p作为脓毒症的诊断生物标志物及其对临床结局的预测价值
Xue Luo,Xin Chen,Ying Gu et al.
Xue Luo et al.
Purpose: This study intends to investigate the relationship between FENDRR and miR-424-5p and their clinical significance in sepsis, aiming to provide new diagnostic markers and prognostic markers for sepsis. ...
Xiaomin Fan,Ziqi Huang,Ziying Chen et al.
Xiaomin Fan et al.
COX inhibitors are frequently used for pain management during the perioperative period and may influence tumor progression and the tumor microenvironment by modulating inflammation and immune responses. This study investigates the effects o...
Mitochondrial DNA from endothelial cells activated the cGAS-STING pathway and regulated pyroptosis in lung ischaemia reperfusion injury after lung transplantation [0.03%]
内皮细胞线粒体DNA活化cGAS-STING信号通路调控肺移植后缺血再灌注肺损伤中pyroptosis
Ying-Nan Ju,Hu Li,Zi-Peng Zhuo et al.
Ying-Nan Ju et al.
Objective: Cell dysfunction and death induced by lung ischaemia-reperfusion injury (LIRI) are the main causes of death in transplant patients. Activation of the cGAS-STING-induced immune response and death plays a critica...
NOD-like receptor family pyrin domain containing 3 (rs10754558) gene polymorphism in chronic spontaneous urticaria: A pilot case-control study [0.03%]
慢性自发性荨麻疹患者中NLRP3（rs10754558）基因多态性的病例对照研究
Aya El Gendy,Fawzia Hassan Abo Ali,Shereen A Baioumy et al.
Aya El Gendy et al.
Background: Chronic spontaneous urticaria (CSU) is a persistent skin condition with no known cause or trigger. The unpredictability of CSU attacks lowers patients' quality of life. NOD-like receptor pyrin domain containin...
Serum KL-6 levels reflect the severity of interstitial lung disease caused by immune checkpoint inhibitors [0.03%]
血清KL-6水平反映免疫检查点抑制剂引起的间质性肺疾病的严重程度
Xiaoping Li,Dan Xue,Qiongying Wei et al.
Xiaoping Li et al.
Tumor immunotherapy, particularly immune checkpoint inhibitors (ICIs), has emerged as a powerful strategy in treating malignant tumors, exhibiting efficacy in both first-line and second-line treatments for advanced non-small cell lung cance...
Downregulation of the immunoproteasome subunit PSMB8 attenuates sepsis-associated acute kidney injury through the NF-κB pathway [0.03%]
免疫蛋白酶体亚基PSMB8的下调通过NF-κB途径缓解脓毒症相关急性肾损伤
Min Li,Wenjia Tong,Chao Dai et al.
Min Li et al.
Sepsis-associated acute kidney injury (S-AKI) is a prevalent and life-threatening complication in hospitalized and critically ill patients. Recent researches indicates that immunoproteasome, especially proteasome 20S subunit beta 8 (PSMB8),...
STING modulates HBV-related acute-on-chronic liver failure by mediating autophagy and macrophage polarization [0.03%]
STING通过调控自噬和巨噬细胞极化影响乙肝相关急性-on-慢性肝功能衰竭
Hao Zhang,Teng Liang,Wanlu Duan et al.
Hao Zhang et al.
Background & aims: HBV-related acute-on-chronic liver failure (HBV-ACLF) is a severe acute liver injury secondary to HBV-related chronic liver disease (with or without cirrhosis) and is characterized by a high short-term ...
M2-like macrophage-derived exosomes inhibit osteoclastogenesis via releasing miR-1227-5p [0.03%]
M2型巨噬细胞来源的外泌体通过释放miR-1227-5p抑制破骨细胞生成
Shan Chen,Jian Liu,Lilei Zhu
Shan Chen
Macrophages play a pivotal role in regulating inflammatory response in periodontitis, a condition characterized by excessive osteoclast differentiation. This study aimed to investigate whether exosomes derived from M2 macrophages regulate o...
Associations of HLA-G 3'UTR polymorphisms and increased HLA-G expression with gastric cancer susceptibility and prognosis [0.03%]
HLA-G 3'UTR多态性及高表达与胃癌易感性和预后的关系研究
Ines Zemni,Daria Bortolotti,Sabrine Dhouioui et al.
Ines Zemni et al.
Background: Gastric cancer (GC) remains a serious health concern and is characterized by a multifactorial etiology involving both genetic and epigenetic factors. The aim of the current study was to examine the relationshi...
Nucleotide receptor P2X7/STAT6 pathway regulates macrophage M2 polarization and its application in CAR-T immunotherapy [0.03%]
核苷酸受体P2X7/STAT6信号通路调控巨噬细胞M2极化及其在CAR-T免疫治疗中的应用研究
Qin Si,Lu Yang,Jie Liu et al.
Qin Si et al.
Background: A key factor underlying the failure of Chimeric Antigen Receptor-T Cell (CAR-T) therapy in ovarian cancer (OC) is the presence of an immunosuppressive tumor microenvironment, which is intricately linked to M2 ...