Shared pyroptosis pathways and crosstalk genes underpin inflammatory links between periodontitis and atherosclerosis [0.03%]
牙周炎和动脉粥样硬化之间炎症关联的共有的细胞焦亡途径和串扰基因
Pinxin Zhan,Zhiying Feng,Xinqi Huang et al.
Pinxin Zhan et al.
Objective: This study aimed to identify crosstalk genes shared between periodontitis (PD) and atherosclerosis (AS) and to investigate their potential connections with pyroptosis-related genes. The goal was to uncover comm...
Expression of human superoxide dismutase (SOD) 1 G93A and chlorovirus ATCV-1 SOD increases the response of macrophages to inflammatory stimulants, including ATCV-1 major capsid protein glycans [0.03%]
人类超氧化物歧化酶(SOD)1G93A和绿藻病毒ATCV-1SOD的表达增强了巨噬细胞对炎性刺激物的反应，包括ATCV-1主要衣壳蛋白糖基化的反应
Thomas M Petro,Ahmed Esmael,Gary L Pattee et al.
Thomas M Petro et al.
One cause of familial Amyotrophic Lateral Sclerosis (ALS) is a mutation in Super Oxide Dismutase 1 (SOD1) whereby amino acid 93 is alanine instead of glycine (SOD1-G93A). Transgenic mice expressing human SOD1-G93A pathogenic variant develop...
Regulation of FOXM1 by HDAC3 Inhibition Ameliorates Macrophage Endoplasmic Reticulum stress and Apoptosis in Mycobacterium tuberculosis Infection [0.03%]
HDAC3抑制调节的FOXM1改善结核分枝杆菌感染中的巨噬细胞内质网应激和凋亡
Jinqi Hao,Lan Zhang,Jiafu Qi et al.
Jinqi Hao et al.
Mycobacterium tuberculosis (Mtb) infection may induce significant damage to the host lung tissues. Endoplasmic reticulum stress (ERS) and apoptosis of macrophages are considered key factors affecting the survival and pathogenicity of intrac...
Integrated analyses uncover new features of atypical memory B cells and novel targets for intervention [0.03%]
综合分析揭示非典型记忆B细胞的新特征及潜在干预靶点
Fuli Fan,Shubei Liu,Bin Wang et al.
Fuli Fan et al.
Background: Atypical memory B (AMB) is a novel subset of B lymphocytes, but its immune features and pathogenetic roles in systemic rheumatic diseases are still largely elusive. This study aimed to characterize transcripto...
The Autoimmune Profiles in the Etiopathogenesis of Granulomatous Lobular Mastitis [0.03%]
肉芽肿性小叶乳腺炎发病机制中的自身免疫特征 профили аутоиммунитета в этиопатогенезе гранулематозного лobarита乳房的肉芽肿性小叶乳腺炎发病机制中的自身免疫特征
Lu Xie,Jiamei Feng,Qingqian Gao et al.
Lu Xie et al.
Objectives: Granulomatous lobular mastitis (GLM) is a chronic breast inflammation with low remission and high recurrence. This study aimed to investigate GLM patients' autoimmune profiles and their correlation with GLM et...
Toll-like receptor upregulation in liver and peripheral blood mononuclear cells of patients with amoebic liver abscess [0.03%]
阿米巴性肝脓肿患者肝脏及外周血单个核细胞中 Toll 样受体的上调表达
Sandhya Khunger,Abhishek Mewara,Upninder Kaur et al.
Sandhya Khunger et al.
Aim: We aimed to understand the host and microbe interactions at the time of infection and inflammatory response in amoebic liver abscess (ALA) patients based on toll-like receptor (TLR) expression (mRNA), cytokine and Ig...
Qufeng epimedium decoction alleviates rheumatoid arthritis through CYLD-antagonized NF-kB activation by deubiquitinating Sirt1 [0.03%]
祛风淫羊藿汤通过去泛素化Sirt1抑制CYLD活化NF-κB缓解类风湿关节炎
Zhiming Wu,Peng Zhang,Wenyan Huang et al.
Zhiming Wu et al.
Background: Rheumatoid arthritis (RA) is a chronic autoimmune disease that markedly limits the patients´ day-to-day functional abilities and life quality. Currently, there is no known cure for RA. Qufeng epimedium decoct...
Inhibiting the alternative pathway of complement by reducing systemic complement factor B: Randomized, double-blind, placebo-controlled phase 1 studies with Sefaxersen [0.03%]
通过降低全身性补体因子B抑制补体的替代途径：Sefaxersen I期随机双盲安慰剂对照研究
Michael L McCaleb,Steven G Hughes,Tamar R Grossman et al.
Michael L McCaleb et al.
An over-active alternative complement pathway has been implicated in the pathophysiology of multiple diseases, including IgA nephropathy and geographic atrophy secondary to age related macular degeneration. In first-in-human double-blind, p...
Precolostral antibody reactivity against Histophilus somni conserved proteins and Escherichia coli whole cells in stillborn and live calves [0.03%]
初乳中仍出生和活产牛犊中致病性Histophilus somni（嗜血巴斯德菌）及大肠杆菌反应抗体的检测
Rafał Baran,Joanna Bajzert,Tadeusz Stefaniak et al.
Rafał Baran et al.
Recent studies have demonstrated that neither the uterus nor the fetal gastrointestinal tract is sterile. We hypothesized that antibodies (Ab) that react with bacterial antigens are common in fetuses. Plasma samples from 121 stillborn calve...
Predictive value and mechanism of lncRNA MANCR for pediatric severe pneumonia via miR-20a-5p / MAPK1 axis [0.03%]
lncRNA MANCR通过miR-20a-5p/MAPK1轴对儿童重症肺炎的预测价值及机制研究
Yuting Cai,Jiaxi Xie,Jinkai Yang
Yuting Cai
Severe community-acquired pneumonia (SCAP) significantly threats the safety of children's lives. Long non-coding RNA (lncRNA) MANCR is overexpressed in lung adenocarcinoma (LUAD) tissue, promote the proliferation, invasion, and migration, d...