Investigation of the HLA locus in autopsy-confirmed progressive supranuclear palsy [0.03%]
尸体确诊进行性核上性麻痹的HLA座位研究
Jinguo Wang,Shelley L Forrest,Sathish Dasari et al.
Jinguo Wang et al.
Objectives: Progressive supranuclear palsy (PSP) is a neurodegenerative disease showing pathological tau accumulation in subcortical neurons and glial cells. The human leukocyte antigen (HLA) locus on chromosome 6 is a po...
Targeting B7-H3 in solid tumors: Development and evaluation of novel CAR-T Cell therapy [0.03%]
针对实体瘤中B7-H3的新型CAR-T细胞疗法的开发与评估
Ning Li,Chunhua Zhang,Xiaoyu Li et al.
Ning Li et al.
Ovarian and gastric cancers, representative of many solid tumors, remain among the most challenging malignancies to treat due to limited therapeutic options and poor outcomes at advanced stages. Although immunotherapies have revolutionized ...
Different doses of hydroxychloroquine regulate the structure of intestinal flora and glycosyltransferase activity in rats with IgA nephropathy [0.03%]
不同剂量的羟氯喹调节IgA肾病大鼠肠道菌群结构和糖基转移酶活性的研究
Lingling Bao,Xueyan Bian,Liling Ren et al.
Lingling Bao et al.
Background: Hydroxychloroquine (HCQ), by virtue of its ability to reduce proteinuria, is an alternative therapy for Immunoglobulin A nephropathy (IgAN). This study investigated the effects of different doses of HCQ on the...
Suppression of astrocyte elevated gene-1 protects against light-induced photoreceptor apoptosis and inflammation in retina [0.03%]
星形胶质细胞升高基因-1的抑制作用可保护视网膜免受光线诱导的光感受器凋亡和炎症反应
Xinran Gao,Haoran Qiao
Xinran Gao
Purpose: To research the function of astrocyte elevated gene-1 (AEG-1) in light-induced retinal degeneration. Methods: The retinas of B...
Assessment of cellular immune phenotype of peripheral blood mononuclear cells in Bangladeshi children with severe acute malnutrition [0.03%]
孟加拉国重度急性营养不良儿童外周血单个核细胞的细胞免疫表型评估
Zannatun Noor,Shaumik Islam,Md Mehedi Hasan et al.
Zannatun Noor et al.
Children suffering from severe acute malnutrition (SAM) have a weakened immune system. The relationship between malnutrition and alterations in the frequency of peripheral blood mononuclear cells (PBMCs) remains unclear. This study investig...
Harnessing miR-16-5p-Loaded Exosomes from Adipose-Derived Stem Cells to Restore Immune Homeostasis in SLE Patients [0.03%]
利用负载miR-16-5p的脂肪源干细胞外泌体恢复SLE患者的免疫稳态
Yin-Hong Zhang,Juan Chen,Wen-Fei Mao et al.
Yin-Hong Zhang et al.
Background: Systemic Lupus Erythematosus (SLE) is an autoimmune disorder marked by an imbalance between pro-inflammatory Th17 cells and regulatory T cells (Tregs), which contributes to chronic inflammation and multi-organ...
Unveiling the Role of Oligosaccharyltransferase STT3B in Colorectal Cancer Tissues: Clinical significance and Molecular Mechanisms Driving the Formation of Tertiary Lymphoid Structures [0.03%]
寡糖转移酶STT3B在结直肠癌组织中的作用机制及临床意义探讨
Caixia Zhang,Bin Wang,Xiaofeng Bian et al.
Caixia Zhang et al.
The role of tertiary lymphatic structures (TLS) in anti-tumor response has garnered increasing attention; however, the clinical implications and regulatory mechanisms of various TLS subtypes remain poorly understood. This study investigates...
Renqing Changjue alleviates sepsis-induced acute lung injury by regulating renin-angiotensin system and inhibiting inflammatory response [0.03%]
仁青常觉通过调节肾素血管紧张素系统和抑制炎症反应缓解脓毒症诱导的急性肺损伤
Minxia Zhu,Yaqi Lei,Zhaojun Zhang et al.
Minxia Zhu et al.
Sepsis, with high morbidity and mortality, represents a systemic inflammatory response syndrome. A common consequence of sepsis is acute lung injury (ALI). Renqing Changjue (RQCJ), a renowned prescription in traditional Tibetan medicine, is...
CVB3 regulates Treg cell pyroptosis through the lncRNA XIST/miR-195-5p/caspase-1 molecular axis [0.03%]
CVB3通过XIST/miR-195-5p/caspase-1分子轴调节Treg细胞焦亡
Yan Zhang,Lei Yang,Huiting Mu et al.
Yan Zhang et al.
Viral myocarditis (VMC) is characterized by severe cardiac inflammation and is a major cause of congestive heart failure and sudden cardiac death in healthy young people. The lncRNA XIST plays an important regulatory role in myocardial inju...
Preclinical models of immune checkpoint inhibitors-related interstitial pneumonia for anti-PD1 tumor immunotherapy [0.03%]
免疫检查点抑制剂相关间质性肺炎的抗PD1肿瘤免疫治疗的临床前模型
Tingyue Luo,Weisheng Chen,Danhui Huang et al.
Tingyue Luo et al.
Immune-related adverse reactions (irAEs) are common adverse reactions after immune checkpoint inhibitor treatment, impacting the universality and continued use of immunotherapy. Currently, preclinical models to investigate the mechanisms un...