Ureaplasma urealyticum GrpE protein elicits glycolysis-mediated inflammatory responses through TLR2 in macrophages [0.03%]
解脲支原体GrpE蛋白通过TLR2诱导巨噬细胞糖酵解介导的炎症反应
Jing Xie,Nan Xie,Chang Liu et al.
Jing Xie et al.
The pathogenesis of Ureaplasma urealyticum infection is linked to the host inflammatory response; however, the specific molecular mechanisms underlying this phenomenon have not been fully elucidated. GrpE is a chaperonin that accelerates AD...
APOE modulates ferroptosis to drive macrophage polarization toward the M2 type and enhance PTC migration and invasion [0.03%]
APOE通过调节铁死亡促进M2型巨噬细胞极化并增强PTC迁移和侵袭
Ziwen Li,Min Li,Sinuo Sun et al.
Ziwen Li et al.
Background: Previous studies have found that Apolipoprotein E (APOE) plays a crucial role in invasion and migration of papillary thyroid carcinoma (PTC) cells and enhance M2 macrophage polarization. Ferroptosis has been i...
Circulating Tfh cells and Tfr cells in papillary thyroid carcinoma and their diagnostic potential [0.03%]
乳头状甲状腺癌中的循环滤泡辅助T细胞和调节性滤泡T细胞及其诊断潜力
Heng Zhang,Yiwen Yu,Minglei Jiang et al.
Heng Zhang et al.
Objective: This study aim to explore the alterations of circulating T follicular helper (Tfh) and T follicular regulatory (Tfr) cells in the peripheral blood of patients with papillary thyroid carcinoma (PTC), assess thei...
APOE Drives Glioma Progression by Modulating CCL5/CCR5 Signaling in the Tumor Microenvironment and Inducing M2 Macrophage Polarization [0.03%]
APOE通过调节肿瘤微环境中的CCL5/CCR5信号并诱导M2型巨噬细胞极化来驱动胶质瘤进展
Wei Huang,Weimin Li,Xingyu Chen et al.
Wei Huang et al.
Background: Tumor-associated macrophages (TAMs) are pivotal in shaping the tumor microenvironment (TME) during cancer progression. Emerging evidence indicates that dysregulation of key signaling pathways in cancer cells d...
A Flow Cytometric Approach to Assess RBC-Bound IgG Antibodies in Different Age Populations [0.03%]
一种评估不同年龄段人群红细胞结合IgG抗体的方法
Anwar Ullah,Lina Liu,Xia Qi et al.
Anwar Ullah et al.
Background: RBC-bound IgG antibody-mediated agglutination occurs when red blood cells (RBCs) cluster together due to the presence of antibodies or other contributing factors. This process could be favorable in the elderly...
Clonal Analysis of Peripheral Blood T Cells in patients with Hashimoto's Thyroiditis at Different Stages using TCR Sequencing [0.03%]
TCR测序在不同阶段桥本甲状腺炎患者外周血T细胞克隆分析研究
Yufeng Liu,Huachao Zhu,Qing Zhang et al.
Yufeng Liu et al.
Background: Hashimoto's Thyroiditis (HT) is a prevalent autoimmune disorder characterized by progressive thyroid damage mediated by T cells. The clonal diversity and expansion of T cells play a critical role in the pathog...
Xi Jiang,Qiaoyu Li,Rongsheng Huang et al.
Xi Jiang et al.
Giardia duodenalis is a globally distributed zoonotic parasite primarily transmitted through the fecal-oral route, infecting various vertebrates, and the infection of which is prevalent in goats. Immune cells play a crucial role in pathogen...
Mechanism and Efficacy of Etanercept in Treating Autoimmune-like Manifestations of Coronavirus Disease 2019 in elderly individuals [0.03%]
艾塞纳肽治疗新型冠状病毒肺炎老年患者自身免疫表现的疗效及机制探讨
Lizhong Zhang,Hongyi Li,Lei Shi et al.
Lizhong Zhang et al.
During the COVID-19 pandemic, extensive research focused on universal treatments, but few studies addressed treatment regimens for elderly patients. This study aimed to evaluate the effects of etanercept, a TNF inhibitor, in elderly individ...
Decreased number of myeloid-derived suppressor cells in the placental trophoblast of gestational diabetes mellitus. Possible role of leptin [0.03%]
妊娠糖尿病胎盘滋养层中髓源性抑制细胞数量减少。脂肪因子的可能作用
Malika Tami,Lourdes Hontecillas-Prieto,Daniel García-Domínguez et al.
Malika Tami et al.
Gestational diabetes mellitus (GDM) is the most common complication of pregnancy and significantly increases both maternal and fetal morbidity and mortality. Inflammation is a hallmark of GDM, and placental inflammation may play a key role ...
High-dose Vitamin C inhibits PD-L1 expression by activating AMPK in colorectal cancer [0.03%]
高剂量维生素C通过激活结肠癌中的AMPK来抑制PD-L1的表达
Jia Huang,Su Min,Ruiyang Hong et al.
Jia Huang et al.
Vitamin C (VitC) has elicited considerable interest regarding its potential role in cancer therapy; however, its effects on tumor immunity remain unclear. In colorectal cancer (CRC), although anti-PD-1/PD-L1 therapies demonstrate promise, t...