Alterations in CD8+CD45RA+CCR7- T cells as a potential biomarker for primary Sjögren's syndrome [0.03%]
外周血CD8+CD45RA+ CCR7- T细胞亚群作为自身免疫性疾病口干燥症的生物标志物的可能性研究
Jie Pan,Rongqiang Wu,Liuyang He et al.
Jie Pan et al.
In this study, we found that the CD8+CD45RA+CCR7- T cell subpopulation was increased in the peripheral blood of patients with primary Sjögren's syndrome (pSS) compared with healthy donors. Moreover, both CD8+TIM-3+ T cells and CD8+CD45RA+C...
QRICH1, as a key effector of endoplasmic reticulum stress, enhances HBV in promoting HMGB1 translocation and secretion in hepatocytes [0.03%]
内质网应激关键效应物QRICH1在HBV促进肝细胞HMGB1转位及分泌中的作用机制研究
Ying Feng,Yucai Geng,Zhixiang Liu et al.
Ying Feng et al.
Background: Extracellular high mobility group box 1 (HMGB1) serves as a damage-associated molecular pattern (DAMP) and leads to diverse biological effects, including the aggravation of HBV-related liver diseases. However,...
USP14 promotes osteoarthritis progression by deubiquitinating FZD8 to activate the Wnt/β-catenin signaling pathway [0.03%]
USP14通过去泛素化FZD8激活Wnt/β-catenin信号通路促进骨关节炎进展
Xiaochao Chen,Tiancheng Ma,Yongfeng Chen et al.
Xiaochao Chen et al.
Background: Osteoarthritis (OA) is a chronic degenerative disease and associated with multiple pathogenic factors, such as old age, heredity, obesity, mechanical damage and inflammatory gene mutation. In this study, we ai...
HMGB1 regulates the activation of dendritic cells and CD4+ T cell responses through the modulation of autophagy in bleomycin-induced pulmonary fibrosis [0.03%]
HMGB1通过调节自噬作用调控支气管肺泡炎中成纤维细胞活化和CD4⁺T细胞反应
Xiuhua Liu,Xinghui Song,Guangting Li et al.
Xiuhua Liu et al.
Background: The role of HMGB1 in inflammation and autophagy has garnered increasing attention; however, its impact on the activation of dendritic cells (DCs) and autophagy remains unclear. This study aims to explore the e...
Interpretable Machine Learning reveals the Role of PANoptosis in the Diagnosis and Subtyping of NAFLD [0.03%]
可解释机器学习揭示了PANoptosis在NAFLD诊断和分型中的作用
Feng Tian,Yuqi Zhao,Xinyang He et al.
Feng Tian et al.
Non-alcoholic fatty liver disease (NAFLD) is a global health challenge characterized by complex pathogenesis and limited therapeutic options. Emerging evidence highlights PANoptosis-a coordinated interplay of pyroptosis, apoptosis, and necr...
CH25H/25-HC promotes pulmonary fibrosis via AMPK/STAT6 pathway-dependent M2 macrophage polarization in COPD [0.03%]
CH25H/25-HC通过AMPK/STAT6通路依赖性M2巨噬细胞极化促进慢性阻塞性肺疾病相关肺纤维化
Ying Li,Guangzhi Xiao,Xianghui Fu et al.
Ying Li et al.
Objective: Chronic obstructive pulmonary disease (COPD) is intricately linked to pulmonary fibrosis, yet the underlying mechanisms remain unclear. This study investigates whether CH25H/25-hydroxycholesterol (25-HC) promot...
Single-cell RNA and TCR repertoire analysis identify markers of virus-specific T cells [0.03%]
单细胞RNA和TCR谱系分析可识别病毒特异性T细胞的标志物
Byung-Kwan Jeong,Young-Ae Kim,Jung-Wook Park et al.
Byung-Kwan Jeong et al.
Adoptive cell therapy (ACT) is a promising method for treating cancer and viral infections. Identifying antigen-specific T cells (ASTs) is critical to ACT. We investigated biomarkers for identifying ASTs. Peripheral blood mononuclear cells ...
Novel diagnostic biomarkers regulating macrophages autophagy in ischemic cardiomyopathy: An analysis integrating bulk RNA sequencing with single-cell RNA sequencing [0.03%]
整合bulkRNA测序与单细胞RNA测序分析缺血性心肌病调控巨噬细胞自噬的新型诊断生物标志物
Weiluan Cen,Yajin Pan,Yaohan Tang et al.
Weiluan Cen et al.
Macrophage autophagy plays a pivotal role in ischemia cardiomyopathy (ICM). However, the underlying mechanisms and macrophage autophagy-related biomarkers in ICM have not been elucidated. Therefore, this study was designed to explore novel ...
Biomarker identification for rheumatoid arthritis with inadequate response to DMARD and TNF therapies using multidimensional analyses [0.03%]
使用多维分析鉴定对DMARD和TNF疗法反应不足的类风湿关节炎生物标志物
Leyuan Li,Hui Guo,Weijin Zhang et al.
Leyuan Li et al.
Purpose: Rheumatoid arthritis (RA) is an immune system disorder disease accompanied with severe joint damage. However, the molecular mechanism of RA with insensitive to medicine remains insufficient. Thus, this study aims...
The Clinical significance of Peripheral Blood-related Inflammatory Markers in patients with AECOPD [0.03%]
急性加重期慢性阻塞性肺疾病患者外周血相关炎症标志物的临床意义
Dehu Li,Lanlan Liu,Jiaxi Lv et al.
Dehu Li et al.
Objective: Peripheral blood-related inflammatory markers, including systemic immune inflammation index (SII), inflammatory response index (SIRI), neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), a...