Targeting the ApoB100-ENO1 Interaction with Engineered Peptides Attenuates Atherosclerotic Inflammation and Plaque Progression [0.03%]
靶向ApoB100-ENO1相互作用的工程肽可减轻动脉粥样硬化炎症和斑块进展
Hyun Jung Yoo,Dan Hoang Nguyet Vo,Shin Eui Kang et al.
Hyun Jung Yoo et al.
Background: Atherosclerosis, a chronic inflammatory disease, presents significant "residual risk" even with effective lipid-lowering therapies, primarily due to persistent vascular inflammation. Apolipoprotein B100 (ApoB1...
Jiayong Lai,XiaoYa Wei,Dantong Li et al.
Jiayong Lai et al.
Tubular dilation and cyst formation at the corticomedullary junction are distinct pathological features of nephronophthisis (NPH) and may be associated with disease progression. However, the mechanism of renal cyst formation in NPH is uncle...
The key role of cellular plasticity in the development of colorectal cancer [0.03%]
结肠直肠癌发病过程中细胞 Plasticity 的关键作用
Lingqiao Lou,Yanghui Cao,Zhiyuan Ma et al.
Lingqiao Lou et al.
The development of colorectal cancer, which is a malignant tumor demonstrating high morbidity and mortality worldwide, involves complex molecular mechanisms and biological processes. Early-stage colorectal cancer patients do not exhibit obv...
Hierarchical Multimodal Structural And Material Analysis of Bone In Diabetes [0.03%]
糖尿病下骨的分层多模态结构和材料分析
Ashu Rastogi,Raveena Singh,Saroj Kumar et al.
Ashu Rastogi et al.
Objective: Diabetic neuropathy and Charcot neuroarthropathy (CN) may compromise lower limb skeletal integrity. We performed a comprehensive comparative assessment of foot bone across multiple hierarchical parameters at na...
Multi-omics analysis identifies S100a10/Anxa2 complex within proximal tubule aggravates acute kidney injury through p-Stat3/Spp1 signaling [0.03%]
多组学分析识别出S100a10/Anxa2复合体通过p-Stat3/Spp1信号通路加剧近端肾小管急性肾损伤的作用机制
Zhejun Chen,Liqing Ye,Minyan Zhu et al.
Zhejun Chen et al.
Background: Acute kidney injury (AKI) has become a global public health problem that seriously endangers human health, the treatment for AKI is mainly supportive and there is no targeted, efficient and low-toxicity treatm...
Unraveling PANoptosis a key player in acute kidney injury and its clinical implications [0.03%]
揭示PANoptosis在急性肾损伤中的作用及其临床意义
Songyuan Yang,Zehua Ye,Sheng Zhao et al.
Songyuan Yang et al.
Acute kidney injury (AKI) represents a significant public health challenge, marked by high rates of incidence and mortality. PANoptosis, a multifaceted process of cell death, involves complex interactions between pyroptosis, apoptosis, and ...
Autoantibody-defined subsets of patients with systemic lupus erythematosus associate with clinical manifestations, NCF2, and HLA DR3-DQ2 genotypes [0.03%]
自身抗体定义的系统性红斑狼疮患者的亚组与临床表现、NCF2和HLA DR3-DQ2基因型相关联
Henrik Christian Bidstrup Leffers,Anne Troldborg,Martin Andersen et al.
Henrik Christian Bidstrup Leffers et al.
Introduction: Understanding the associations between genetic markers, serological subsets and clinical manifestations in patients with Systemic lupus erythematosus (SLE) may elucidate disease mechanisms and inform persona...
Mesenteric adipocytes promote intestinal fibrosis and inflammation in Crohn's disease through epiregulin (EREG) [0.03%]
肠系膜脂肪细胞通过表皮生长因子样生长因子(EREG)促进克罗恩病肠道纤维化和炎症反应
Yawei Zhang,Hengchang Yao,Kailing Xie et al.
Yawei Zhang et al.
Background: The global incidence rate of Crohn's disease (CD) is rising, with mesenteric adipose tissue (MAT) playing a pivotal role in CD progression, particularly in fibrosis development. This study aimed to identify ke...
Unveiling the molecular mechanisms of hemorrhagic shock and acute lung injury: An integrative RNA-Seq and network analysis [0.03%]
出血性休克和急性肺损伤的分子机制解析：整合RNA测序与网络分析方法
Manjaree Mishra,Shivangi Agrawal,Shashi P Mishra et al.
Manjaree Mishra et al.
Acute lung injury (ALI), especially when resulting from trauma-associated hemorrhagic shock (THS), is a life-threatening condition with limited treatment options and high mortality. Understanding the molecular mechanisms driving ALI in this...
Enhancing Specific Thymic Treg Activation and Function with 4-1BB Monomeric Streptavidin-Based CARs [0.03%]
利用4-1BB单体链霉亲和素基CAR增强胸腺特异性Treg活化和功能
Jorge Gallego-Valle,Verónica Astrid Pérez-Fernández,Ana Pita et al.
Jorge Gallego-Valle et al.
Hyperinflammatory diseases arise from excessive immune activation, causing tissue damage and systemic inflammation. Regulatory T (Treg) cells play a key role in maintaining immune homeostasis, but their function or numbers may be impaired i...