Anti-IL-33 monoclonal antibody attenuates MAILD by suppressing the PI3K/AKT/mTOR signal pathway [0.03%]
抗IL-33单克隆抗体通过抑制PI3K/Akt/mTOR信号通路缓解MAILD
Jumei Yang,Zhuanhui Huang,Liqiong Men et al.
Jumei Yang et al.
Background: Interstitial lung disease (ILD) is a serious complication of idiopathic inflammatory myopathies (IIM) for which targeted therapies are lacking. Our previous work identified interleukin‑33 (IL‑33) as playing ...
Corrigendum to "Circ-PHC3 promotes malignant progression of ovarian cancer through regulating miR-512-3p/SLC2A1/HK2 mediated glucose metabolism" [Translational Research 294, 2026, 1-9] [0.03%]
“环状RNA Circ-PHC3通过circ-PHC3/miR-512-3p/SLC2A1/HK2轴调控葡萄糖代谢促进卵巢癌恶性进展”一文的勘误[《转化研究》2026, 294, 1-9]
Jinghua Tian,Fenghua Zhang,Zhengmao Zhang et al.
Jinghua Tian et al.
From JAK2 Degradation to Precision Immunotherapy: A Translational Passport for Strebloside in Epstein-Barr Virus-Associated Gastric Cancer [0.03%]
从jak2降解到精准免疫治疗：斯特布洛苷在eb病毒相关胃癌中转化之旅的通行证
M Vijayasimha,M Srikanth,K Purushothama Reddy
M Vijayasimha
Dynamic 3D imaging system detects vasculogenic mimicry and screens inhibitors in EGFR-mutant lung cancer [0.03%]
动态3D成像系统检测表皮生长因子受体突变型肺癌的血管生成模仿并筛选抑制剂
Chun-Hui Lee,Shang-Yin Wu,Wei-Pang Chung et al.
Chun-Hui Lee et al.
Vasculogenic mimicry (VM), wherein tumor cells form vessel-like structures independent of endothelial cells, drives metastasis and therapeutic resistance. Current in vitro VM research relies on conventional two-dimensional imaging, which fa...
From FLOW to translational positioning in chronic kidney disease: mechanistic complementarity of SGLT2 inhibitors and GLP-1 receptor agonists [0.03%]
从肾小球高滤过到慢性肾脏病的转归定位：钠葡萄糖共转运体2抑制剂与胰高血糖素样肽1受体激动剂机制互补性探讨
Xue Tian,Xiaoying Ma,Enxue Song et al.
Xue Tian et al.
Chronic kidney disease is a central node of the cardio-kidney-metabolic continuum and carries substantial residual cardiovascular and kidney risk. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) have reproducibly reduced kidney disease p...
Electroactive Scaffolds for Spinal Cord Injury Repair: Modulating the Electrophysiological Homeostasis [0.03%]
电活性支架在脊髓损伤修复中的应用：调节电生理稳态
Xiaochen Su,Shenglong Wang,Jing Tian et al.
Xiaochen Su et al.
Spinal cord injury (SCI) is a devastating neurological disorder characterized by neuronal loss, glial activation, disruption of electrophysiological homeostasis, and disconnection of neural circuits. Increasing evidence indicates that endog...
A Parabrachial GABAergic-Glutamatergic Circuit Regulates Sevoflurane Anesthesia via the PB→PVT Pathway [0.03%]
旁泌脑GABA能-谷氨酸神经环路通过PB→PVT通路调节异氟醚麻醉作用
Jing Wang,Ninan Dai,Miaoyi Han et al.
Jing Wang et al.
Although general anesthetics have been clinically applied for decades, their neural mechanisms of action remain incompletely understood. Emerging evidence indicates that the parabrachial nucleus (PB) and the paraventricular thalamus (PVT) a...
Multidimensional Regulatory Mechanisms and Targeted Intervention Strategies of the Gut-Joint Axis in Metabolic Osteoarthritis [0.03%]
肠道-关节轴在代谢性骨关节炎中的多维度调节机制及靶向干预策略
Rongrong Chai,Jinfeng Liu,Liang Hu et al.
Rongrong Chai et al.
Osteoarthritis (OA) is increasingly recognized as a heterogeneous disease driven not only by mechanical overload but also by systemic metabolic and inflammatory disturbances, among which metabolic osteoarthritis (Met OA) represents a distin...
Targeting Soluble PD-1 Alleviates Peritoneal Fibrosis by Modulating PD-L1 Recycling and Mesothelial-Mesenchymal Transition [0.03%]
靶向可溶性PD-1通过调节PD-L1循环和间皮细胞间充质转化来缓解腹膜纤维化
Hongbin Peng,Shidong Feng,Kaiying Xiao et al.
Hongbin Peng et al.
Background: Peritoneal fibrosis (PF) is a major cause of technique failure in long-term peritoneal dialysis (PD) patients, driven by a chronic microinflammatory state. While T-cell activation is implicated, the role of so...
Jinghan Yang,Aijing Cao,Xiaojing Liu
Jinghan Yang
Cellular senescence is a fundamental driver of aging and age-related diseases. While traditionally attributed to biochemical cues, accumulating evidence identifies cellular mechanics as a critical regulator of senescence. Cells continuously...