In vivo generation of CD19 CAR T cells for the treatment of mouse systemic lupus erythematosus [0.03%]
体内生成CD19 CAR-T细胞治疗小鼠系统性红斑狼疮
Haojun Xie,Daxiang Chen,Ziyun Lin et al.
Haojun Xie et al.
Objective: Systemic lupus erythematosus (SLE) is a severe autoimmune disease with significant health impacts, yet effective therapies remain elusive. Recent advances underscore the promise of chimeric antigen receptor (CA...
miR-221-3p-mediated CPT2 suppression links cardiomyocyte metabolic stress to NET-associated inflammation in myocardial ischemia-reperfusion injury: Multi-omics evidence and experimental validation [0.03%]
miR-221-3p介导的CPT2抑制将心肌细胞代谢压力与NET相关炎症联系起来，用于心肌缺血再灌注损伤：多组学证据和实验验证
Malike Mutailipu,Abudousaimi Aini,Duolikun Mutailifu et al.
Malike Mutailipu et al.
Background: Impaired fatty acid oxidation (FAO) and neutrophil extracellular trap (NET) formation (NETosis) contribute to myocardial ischemia-reperfusion injury (MIRI). Whether cardiomyocyte metabolic dysfunction contribu...
The G-quadruplex ligand CX-5461 inhibits laryngeal cancer via inducing immunogenic cell death and remodeling the tumor immune microenvironment [0.03%]
G四链体配体CX-5461通过诱导免疫原性细胞死亡和重塑肿瘤免疫微环境抑制喉癌
Fang-Yuan Teng,Bo Zhang,Yue-Xi Liu et al.
Fang-Yuan Teng et al.
Background and objective: G-quadruplex (G4) structures, formed by guanine-rich nucleic acids, are implicated in tumor progression and represent promising therapeutic targets. In laryngeal cancer, the profile and clinical ...
JOSD2 attenuates the aggressive behavior of fibroblast-like synoviocytes in rheumatoid arthritis by deubiquitinating and stabilizing ZNF148 [0.03%]
JOSD2通过去泛素化和稳定ZNF148来抑制类风湿关节炎滑膜成纤维细胞的侵袭行为
Teng Wu,Qingshui Wen,Yunan Wang et al.
Teng Wu et al.
Background: Activated fibroblast-like synoviocytes (FLS) significantly promote synovial inflammation and bone destruction in rheumatoid arthritis (RA). Emerging evidence illustrates that ubiquitination significantly drive...
A novel LncRNA TUG1/miR-30d/e-3p/SNAI2 ceRNA axis drives dermal fibrosis in systemic sclerosis via direct transcriptional activation of COL1A1 [0.03%]
新颖的长链非编码RNA TUG1/miR-30d/e-3p/SNAI2 ceRNA轴通过COL1A1的直接转录激活驱动系统性硬化症皮肤纤维化
Ruixuan Zhu,Yangfan Xiao,Licong Liu et al.
Ruixuan Zhu et al.
Systemic sclerosis (SSc) is a severe autoimmune disease characterized by progressive dermal fibrosis, aberrant fibroblast activation, and excessive collagen deposition. Although noncoding RNA-mediated regulation has been increasingly implic...
A novel LncRNA TUG1/miR-30d/e-3p/SNAI2 ceRNA axis drives dermal fibrosis in systemic sclerosis via direct transcriptional activation of COL1A1 [0.03%]
长链非编码RNA TUG1通过直接转录激活COL1A1驱动系统性硬化症皮肤纤维化的新机制
Ruixuan Zhu,Yangfan Xiao,Licong Liu et al.
Ruixuan Zhu et al.
Systemic sclerosis (SSc) is a severe autoimmune disease characterized by progressive dermal fibrosis, aberrant fibroblast activation, and excessive collagen deposition. Although noncoding RNA-mediated regulation has been increasingly implic...
GSK3β-mediated phosphorylation of IF1 at Ser27 destabilizes mitochondrial ATP synthase inhibitory factor 1 to aggravate cardiac ischemia/reperfusion injury [0.03%]
GSK3β介导的IF1丝氨酸27磷酸化通过削弱线粒体ATP合酶抑制因子1的稳定性加重心脏缺血再灌注损伤
Beiduo Tian,Yao Dong,Chenlu Yuan et al.
Beiduo Tian et al.
Objectives: Myocardial ischemia-reperfusion (I/R) injury is a major cause of ischemic cardiomyopathy and chronic heart failure, underscoring the need for new cardioprotective strategies. ATP synthase inhibitory factor 1 (...
The gut-kidney axis revisited: Integrating gut microbiota, autophagy and metabolomics in chronic kidney disease [0.03%]
从肠道-肾脏轴再思考：慢性肾病中整合肠菌群、自噬和代谢组学
Khemender Lidoo,Rupinder Kaur,Ravinder Singh et al.
Khemender Lidoo et al.
Chronic kidney disease (CKD) is increasingly recognised as a systemic disorder driven by interconnected disturbances in gut microbial balance, metabolic regulation and renal cellular stress responses rather than by isolated renal dysfunctio...
A plasmid-loaded biomimetic nanoplatform targeting the PAD2-METs-OPN axis against recurrent herpes simplex keratitis [0.03%]
靶向PAD2-METs-OPN轴的质粒负载仿生纳米平台用于复发性单纯疱疹病毒角膜炎治疗
Junpeng Liu,Ting Chu,Mimi Wan et al.
Junpeng Liu et al.
The high recurrence rate of herpes simplex keratitis (HSK) is primarily attributed to the reactivation of herpes simplex virus type 1 (HSV-1) within the trigeminal ganglion (TG), a latent viral reservoir cannot be eradicated by current anti...
KLF6-driven macrophage-to-myofibroblast transition promotes PD-L1-mediated immune evasion in bladder cancer [0.03%]
膀胱癌中KLF6诱导的巨噬细胞向肌成纤维细胞转化促进PD-L1介导的免疫逃逸
Yuwen Chen,Zihuan Wang,Chengwu He et al.
Yuwen Chen et al.
Background: Although PD-1/PD-L1 inhibitors are central to the management of advanced bladder cancer, most patients fail to achieve a meaningful response. While evidence ties MMT to fibrotic disease, its contribution to bl...