Dysregulation of copper metabolism and organelle-driven cellular injury: Mechanisms and therapeutic implications [0.03%]
铜代谢紊乱及细胞器介导的细胞损伤：机制和治疗意义
Ting Yang,Yunjie Zheng,Yanfei Ju et al.
Ting Yang et al.
Copper is an essential trace element required for numerous physiological processes, with its systemic metabolism closely centered in the liver. This review systematically elucidates the mechanisms governing copper metabolism, emphasizing th...
Targeting ACOT1-SLC25A5 Axis attenuates LPS-induced acute liver injury by inhibiting ferroptosis and inflammatory responses [0.03%]
靶向ACOT1-SLC25A5轴通过抑制铁死亡和炎症反应缓解LPS诱导的急性肝损伤
Chengzhu Xu,Shun Wang,Xiyang Wang et al.
Chengzhu Xu et al.
Sepsis associated acute liver injury is a major contributor to multiple organ dysfunction and mortality in critically ill patients. ACOT1 has emerged as a promising therapeutic target, demonstrated to inhibit disseminated intravascular coag...
Extracellular vesicles derived from M1 macrophages deliver miR-515-5p to suppress trophoblast migration and invasion by targeting YAP in preeclampsia [0.03%]
来源于M1型巨噬细胞的细胞外囊泡通过递送miR-515-5p靶向调控YAP抑制胎盘侵袭细胞迁移在子痫前期中的作用机制研究
Hanhui Nie,Xiufang Wang,Heyi Tian et al.
Hanhui Nie et al.
Trophoblast migration and invasion are critical processes in the pathogenesis of preeclampsia (PE), with maternal-fetal cellular communication playing a key role in their regulation. Among the immune components at the maternal-fetal interfa...
Apigenin-7-O-β-D-glucuronide prophylaxis ameliorates allergic airway inflammation by suppressing the TCF4-mediated Syk pathway [0.03%]
染料木素-7-O-β-D-葡萄糖醛酸酯通过抑制TCF4介导的Syk通路改善过敏性气道炎症
Hui Yang,Yewei Chen,Yiping Wang et al.
Hui Yang et al.
Background: Asthma has traditionally been characterized by persistent airway inflammation. Innovative therapeutic target and specific pharmacologic intervention remain essential for effectively managing inflammatory condi...
Beyond flavor perception: The role of the taste receptor family in immunity [0.03%]
味觉感知之外：味觉受体家族在免疫中的作用
Ni Ye,Bin Wang,Zhentao Cheng et al.
Ni Ye et al.
Taste receptor family 1 (T1R) and taste receptor family 2 (T2R) are G protein-coupled receptors (GPCRs) responsible for sweet, umami, and bitter taste perception. Their widespread ectopic expression of T1Rs and T2Rs in extraoral tissues sug...
Serum calprotectin as a biomarker for large vessel vasculitis: a multicenter cross-sectional study [0.03%]
血清钙卫蛋白作为大血管炎生物标志物的多中心横断面研究
Sidar Çöpür,Ayşegül Avcu,Nagehan Dik Kutlu et al.
Sidar Çöpür et al.
Objective: Large vessel vasculitis (LVV), namely Takayasu arteritis (TAK) and giant cell arteritis (GCA), is the most common type of primary vasculitis affecting adult patients with significant and potentially debilitatin...
Cardiac ACY1 ameliorates pathological hypertrophy by suppressing β-catenin/TCF4 signaling [0.03%]
心脏ACY1通过抑制β-连环素/TCF4信号通路改善病理性心室肥大
Yangxian Chen,Qiong Lai,Shengai Ye et al.
Yangxian Chen et al.
Pathological cardiac hypertrophy induced by pressure overload is a critical precursor to heart failure, necessitating the identification of novel pathogenesis-specific therapeutic targets. Here, we identify aminoacylase-1 (ACY1), a central ...
Network pharmacology and virtual screening suggest neoprzewaquinone a as a potential therapeutic agent for rheumatoid arthritis, validated in fibroblast-like synoviocytes and collagen-induced arthritis models [0.03%]
网络药理学和虚拟筛选相结合提示新博来霉素醌亚胺A可能是治疗类风湿关节炎的药物，并在滑膜成纤维细胞系和胶原诱导的鼠性关节炎模型中得到验证
Qingyang Liu,Yuan Tan,Fengying Jiang et al.
Qingyang Liu et al.
Currently, utilized disease-modifying antirheumatic drugs (DMARDs) do not provide a complete cure for rheumatoid arthritis (RA) and are associated with side effects related to prolonged use. In contrast, natural products have demonstrated p...
FABP5 attenuates pulmonary fibrosis by regulating lipid metabolism in type II alveolar epithelial cells [0.03%]
脂肪结合蛋白FABP5通过调节II型肺泡上皮细胞脂质代谢抑制肺纤维化
Hang Yin,Zhixiang Lei,Yuqi Mai et al.
Hang Yin et al.
Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive disease resulting from alveolar epithelial cell injury. Senescence and dysfunction of alveolar epithelial type II (AT2) cells are key drivers of IPF pathogenesis. Given that meta...
Discovery and development of small-molecule inhibitors targeting cytotoxic T lymphocyte associated protein 4 to enhance cancer immunotherapy and reduce side effects [0.03%]
靶向细胞毒T淋巴细胞相关蛋白4的小分子抑制剂的发现和开发以增强癌症免疫治疗和减少副作用
Chong Yu,Xiaohua Zhou,Wenqiang Chen et al.
Chong Yu et al.
The immune system plays crucial role to fight against cancer. Still, cancer cells have evolved mechanisms to evade immune responses, especially through immune checkpoint proteins such as cytotoxic T-lymphocyte-associated protein 4 (CTLA-4),...