Emerging roles of KLF4 regulation of autophagy in different physiological and pathological processes [0.03%]
KLF4调控自噬在不同生理及病理过程中的新兴作用
Chenglin Zhu,Qi Zhang,Hao Fan et al.
Chenglin Zhu et al.
Krüppel-like factor 4 (KLF4) is a zinc finger transcription factor that exhibits both transcriptional activation and inhibition effects. It participates in the occurrence and development of various diseases by regulating processes such as ...
Metformin mitigates inflammation and apoptosis in salivary gland epithelial cells via an AMPK-dependent mechanism in chronic obstructive sialadenitis [0.03%]
二甲双胍通过AMPK依赖性机制缓解慢性阻塞性腮腺炎中唾液腺上皮细胞的炎症和凋亡
Lianhao Wang,Boyuan Peng,Shijiao Pan et al.
Lianhao Wang et al.
Chronic obstructive sialadenitis (COS) frequently results from apoptosis and inflammation in salivary gland epithelial cells, leading to salivary secretion dysfunction. Our previous research suggested that metformin (MET) might have a prote...
3C3 alleviates atopic dermatitis-like phenotypes through cyclophilin A and B-mediated inhibition of calcineurin-NFAT pathway [0.03%]
3C3通过环孢肽A和B介导的钙调神经磷酸酶-NFAT通路抑制作用缓解特应性皮炎样表型
Yejin Jo,Hayan Jeong,Su-Jin Lee et al.
Yejin Jo et al.
Atopic dermatitis (AD) disrupts a patients' quality of life and is associated with other atopic disorders, such as food allergy, allergic rhinitis, and asthma. Although topical medications are widely used, they have undesirable side effects...
In silico analysis of VEGFR2 and c-MET in consideration with immunologic facts: Implications for mRNA vaccine design against breast cancer [0.03%]
基于免疫学事实的VEGFR2和c-MET的计算机分析及其在乳腺癌mRNA疫苗设计中的应用启示
Marziyeh Ghayoumian,Fahimeh Shamsi,Hamid Madanchi et al.
Marziyeh Ghayoumian et al.
Active immunization in cancer therapy can induce tumor-specific immune responses without harming the normal cells. Among these approaches, especially after the success of FDA-approved mRNA vaccines, this platform has gained much more attent...
5-aminolaevulinic acid combined with sodium ferrous citrate ameliorated collagen-induced arthritis via anti-inflammatory effects and fibroblast-like synoviocytes-driven B cell immunomodulation [0.03%]
5氨基乙醛酸联合枸橼酸亚铁通过抗炎作用和类风湿滑膜细胞驱动的B细胞免疫调节改善胶原诱导的关节炎
Zhaolun Ding,Kuai Ma,Atsuko Kamiya et al.
Zhaolun Ding et al.
Purpose: This study evaluated the therapeutic potential of 5-aminolevulinic acid combined with sodium ferrous citrate (5-ALA/SFC) for rheumatoid arthritis (RA), focusing on its dual anti-inflammatory and immunomodulatory ...
Mechanistic insights into SUMOylation and its role in cancer pathogenesis: bridging oncogenesis, immunity, and therapeutic opportunities [0.03%]
SUMO化修饰的机制学说及其在癌症发生发展中的作用：连接肿瘤发生、免疫和治疗机会
Wei Qu,Jinning Gu,Shanshan Liu et al.
Wei Qu et al.
SUMOylation is a post-translational modification mediated by SUMO proteins, a family of small ubiquitin-like biological macromolecules that covalently attach to specific lysine residues in target proteins. This modification regulates variou...
Mohammad Abuzar Shaikh,Ziyaul Haque,Anzarul Haque et al.
Mohammad Abuzar Shaikh et al.
Over 125 million individuals worldwide suffer from psoriasis, a chronic inflammatory skin condition that is immune-mediated. It is often linked to systemic comorbidities such psoriatic arthritis, cardiovascular disease, and mental health co...
Harnessing the chimeric antigen receptor engineered cells in gastrointestinal cancer immunotherapy [0.03%]
嵌合抗原受体工程细胞在胃肠癌免疫治疗中的应用
Arash Dadvand,Mohsen Nooroulahi,Somaieh Matin et al.
Arash Dadvand et al.
Gastrointestinal (GI) cancers pose a significant global health concern. Their prevalence is continually increasing, and managing them remains a significant clinical hurdle. Adoptive cell therapies designed to express chimeric antigen recept...
Metformin inhibits NF-κB p65/RelA-NLRP3 inflammasome-IL-1β axis, attenuates lipid droplet accumulation, and reprograms CD14/CD16 expression in monocytes exposed to colorectal tumor-conditioned medium [0.03%]
二甲双胍通过抑制NF-κB p65/RelA-NLRP3炎性小体-IL-1β轴，减轻脂滴积累并重新编程结肠直肠癌肿瘤细胞培养上清液刺激单核细胞分化出的瘤样巨噬细胞的CD14/CD16表达
Nihel Chahinez Djebri,Souad Zoudji,Aida Messaoud et al.
Nihel Chahinez Djebri et al.
Background: Colorectal cancer (CRC) generates a complex tumor microenvironment (TME) known to profoundly alter the function and phenotype of immune cells, including monocytes. Key aspects of this environment can be mimick...
Agrimonolide from Agrimonia pilosa Ledeb attenuates cholestatic liver injury and macrophage infiltration via the inhibition of bile acid excretion transporters [0.03%]
Agrimonia pilosa Ledeb中的 agrimonolide通过抑制胆汁酸排泄转运蛋白缓解胆汁淤积性肝损伤和巨噬细胞浸润
Leng Han,Keyuan Chen,Jiaqi Liu et al.
Leng Han et al.
Background: Cholestasis is a complex hepatobiliary syndrome without effective treatment. Agrimonia pilosa Ledeb has been used in traditional Chinese medicine for centuries to treat various diseases, including inflammatory...