Pulmonary cold sensing through Club cells triggers adipose thermogenesis to ameliorate obesity [0.03%]
肺部冷感受通过克拉细胞触发脂肪组织产热以改善肥胖问题
Junkun Jiang,Chengrui Liang,Zelin Wang et al.
Junkun Jiang et al.
Cold exposure is a well-known trigger for thermogenesis, primarily through skin cold-sensitive neurons activating adipose metabolism via the central nervous system (CNS). However, whether the lungs-also exposed to cold air-function as a col...
Longitudinal zone- and cell type-specific pattern-triggered immune responses in Arabidopsis roots [0.03%]
拟南芥根系纵向区域和细胞类型的模式触发免疫反应图式
Lahong Xu,Fausto Andres Ortiz-Morea,Sung-Il Kim et al.
Lahong Xu et al.
Roots, composed of diverse cell types across longitudinal developmental zones, are vital for plant survival against microbial challenges. Leveraging single-cell transcriptomics and live-cell imaging of Arabidopsis roots, we reveal here that...
The actin crosslinker Fimbrin is required for force sensing at tricellular junctions [0.03%]
黏蛋白交叉连接蛋白细丝蛋白是三细胞间力学感知所必需的
Nilay Taneja,Claire A Looney,Michael F Moubarak et al.
Nilay Taneja et al.
Epithelial cells sense and respond to mechanical forces by reinforcing connections between adherens junctions and the actin cytoskeleton. Tricellular junctions are key sites of mechanotransduction in epithelial cells, but how force response...
Molecular dynamics driving phenotypic divergence among KRAS mutants in pancreatic tumorigenesis [0.03%]
胰腺肿瘤发生过程中KRAS突变体表型分化的分子动力学机制
Adrien Grimont,David J Falvo,Whitney J Sisso et al.
Adrien Grimont et al.
Inflammation in the pancreas drives acinar-to-ductal metaplasia (ADM), a progenitor-like state that can be hijacked by mutant Kras in the formation of pancreatic ductal adenocarcinoma. How these cell fate decisions vary according to KRAS mu...
Robin M Skory,Ana Domingo-Muelas,Sarah Declercq et al.
Robin M Skory et al.
Fertilization involves dynamic sperm-egg interactions, yet has been primarily studied in static samples. Here, we use high-resolution live imaging to capture fertilization from the moment of sperm binding in zona-intact mouse oocytes. We id...
Tissue tension permits β-catenin phosphorylation to drive mesoderm specification in human embryonic stem cells [0.03%]
组织张力允许β-连环蛋白磷酸化驱动人胚胎干细胞中的中胚层分化
Nadia M E Ayad,Aisha Almsoud,Johnathon N Lakins et al.
Nadia M E Ayad et al.
The role of morphogenetic forces in cell fate specification is an area of intense interest. Using an ectopically expressed nonphosphorylatable mutant of β-catenin (Y654F) in human embryonic stem cell colonies, we provide evidence that impe...
Noncanonical caps, m6A, and Ψ RNA modifications in plant and animal development [0.03%]
非经典的帽结构、m6A和Ψ RNA修饰在植物及动物发育中的作用
Xuemei Chen,Hao Hu,Guifang Jia et al.
Xuemei Chen et al.
RNA modifications constitute a dynamic layer of gene regulation during development. Among them, noncanonical caps, N6-methyladenosine (m6A), and pseudouridine (Ψ) represent three major classes of chemical marks. Noncanonical caps diversify...
Thomas Greb,Jan U Lohmann
Thomas Greb
Plants maintain active stem cell populations throughout their lives, yet these systems are remarkably resilient to genetic, environmental, and mechanical perturbations. Synthesizing evidence from the shoot apical meristem, root apical meris...
Kristina Sakers,Patrick W Sheehan,Wendy Xin et al.
Kristina Sakers et al.
Over the past ∼25 years, our understanding of neural circuit development in the central nervous system has shifted. Once considered passive supporters, glial cells, namely, astrocytes, oligodendrocyte lineage cells, and microglia, are incr...
Johanna Ivaska,Sarah Sale,Alpha S Yap
Johanna Ivaska
Cancers are complex cellular communities comprising tumor cells and their microenvironment. Recent advances in cancer biology have emerged from efforts to analyze tumors as tissues, in which emergent properties arise as tumor cells interact...