Glycoproteomic characterization of Neuropilin-1 reveals critical glycosylation sites for SARS-CoV-2 entry [0.03%]
神经纤毛蛋白-1的糖蛋白组学表征揭示了SARS-CoV-2进入的关键糖基化位点
Tuhin Das,Shuhong Luo,Panning Wang et al.
Tuhin Das et al.
The binding of the SARS-CoV-2 spike (S) glycoprotein to human host receptors, including ACE2, NRP1, and AXL, is essential for viral entry. Glycosylation of both the spike protein and its host receptors can significantly influence these inte...
Modulation of thermomechanical-induced albumin aggregation by extracts of Centella asiatica [0.03%]
羟基喜树碱脂质体的制备及其药代动力学研究
Laipubam Gayatri Sharma,Sanjana SenthilKumar,Latha Rangan et al.
Laipubam Gayatri Sharma et al.
In this study, Centella asiatica extracts obtained through sequential extraction in ethyl acetate (CEE), methanol (CME), and water (CWE) were explored for the inhibition of thermal and thermomechanical-induced aggregation of albumin. Th-T f...
Biochemical and kinetic properties of quinone oxidoreductase from Leishmania orientalis, a member of medium-chain dehydrogenase/reductase superfamily [0.03%]
沙粒菌东方利什曼原虫苯醌氧化还原酶的生化和动力学性质——中链脱氢酶/还原酶超家族成员
Panu Pimviriyakul,Sumita Harungsee,Theerapat Tangsupatawat et al.
Panu Pimviriyakul et al.
Soluble quinone oxidoreductase (QOR) is an attractive target for treating leishmaniasis. In this study, a QOR from Leishmania orientalis PCM2 (LoQOR) was identified as a member of nonZn2+ medium-chain dehydrogenase/reductase (MDR) superfami...
Human mitochondrial pyrophosphatase hPPA2: In vitro and in silico study of the factors affecting its function [0.03%]
人类线粒体焦磷酸酶hPPA2：影响其功能的因素的体内和体外研究
Svetlana Kurilova,Nataliya Vorobyeva,Ekaterina Bezpalaya et al.
Svetlana Kurilova et al.
Biallelic mutations in a nuclear gene PPA2 in human encoding mitochondrial inorganic pyrophosphatase hPPA2 cause mitochondrial disfunctions leading to severe cardiac pathology. This protein catalyzes a Mg2+-dependent hydrolysis of pyrophosp...
Ishadi K M Kodikara,Valentine O Nwanelo,Angela K Belanger et al.
Ishadi K M Kodikara et al.
HDAC7 (histone deacetylase 7) is involved in many diseases, including breast cancer. HDAC7 regulates gene expression epigenetically by assisting in the deacetylation of nucleosomal histones to remodel chromatin. However, HDAC7 is a pseudode...
Victor G Chrone,Johan C Jespersen,Daut C Asani et al.
Victor G Chrone et al.
Immunoglobulin G (IgG) is fundamental to adaptive immunity and numerous monoclonal IgGs (monoclonal antibodies (MAbs)) have been developed as therapeutics for various diseases, including ocrelizumab (OMAb), a CD20 MAb used for treating mult...
Oxygen-carrying proteins employed in blood substitute candidates: differences in interactions with a model antioxidant molecule [0.03%]
氧载体蛋白在血液替代品中的应用：与一种模型抗氧化剂分子相互作用的差异
Maria Lehene,Jozsef Simon,Cezara Zagrean-Tuza et al.
Maria Lehene et al.
Glutaraldehyde-polymerized hemoglobin (poly-Hb) has long been explored as a key candidate for blood substitute compositions, to be used in transfusions in order to supplement the oxygen-carrying capacity following severe blood loss. Bovine ...
Crystal structure and molecular dynamics simulation of Mycobacterium tuberculosis MaoC-like dehydratase HtdX provide insights into substrate binding and membrane interactions [0.03%]
结核分枝杆菌MaoC样去水化酶HtdX的晶体结构和分子动力学模拟提供了底物结合及膜相互作用的新见解
Rupam Biswas,Gourab Bhattacharje,Bina Kumari Singh et al.
Rupam Biswas et al.
The growing challenge of drug resistance has intensified the search for new therapeutic targets against the virulent pathogen Mycobacterium tuberculosis (Mtb). The complex cell envelope of Mtb contains unique lipids, such as mycolic acids, ...
Unravelling the phosphoregulatory network of protein kinase C-delta (PKC-δ) [0.03%]
蛋白激酶Cdelta的磷酸调节网络研究
Darshan Hebbal Raghu,Leona Dcunha,Mukhtar Ahmed et al.
Darshan Hebbal Raghu et al.
Protein kinase C Delta (PRKCD) is a serine/threonine kinase involved in transcription regulation, cytoskeleton organization, DNA damage response, DNA repair and carcinogenesis. Several PRKCD phosphopeptides are frequently detected to be dif...
Elucidation of multifunctionality and substrate specificity of human aspartate aminotransferases [0.03%]
人类天冬氨酸转氨酶多功能性和底物特异性的阐明
Tetsuya Miyamoto,Haruna Kito,Karen Sato et al.
Tetsuya Miyamoto et al.
d-Serine and d-aspartate play crucial physiological roles in mammals. d-Serine is produced by serine racemase, but the biosynthetic pathway of d-aspartate remains unclear. In this study, we investigated the substrate specificity and multifu...