Investigation of adipocyte differentiation based on proteomics and intact N-glycopeptide modificationomics [0.03%]
基于蛋白质组和完整N-糖肽修饰组的脂肪细胞分化研究
Xin-Yu Li,Nuerbiye Nuermaimaiti,Xuanyu Meng et al.
Xin-Yu Li et al.
Objective: To investigate the role of N-glycosylation modification of proteins in adipocyte differentiation during the adipogenic process. Methods: ...
Structural insights into the mechanism underlying the dual cofactor specificity of glyoxylate reductase from Acetobacter aceti in the β-hydroxyacid dehydrogenase family [0.03%]
丙二酸脱氢酶家族中醋杆菌甘氨酸还原酶双辅助因子特异性的机制研究
Toma Rani Majumder,Takuya Yoshizawa,Masao Inoue et al.
Toma Rani Majumder et al.
The β-hydroxyacid dehydrogenase family exhibits diverse cofactor preferences: some enzymes favor NAD, others favor NADP, and a subset can utilize both NAD and NADPH. Glyoxylate reductase from Acetobacter aceti JCM 20276 (AacGR) exhibits a ...
Structure and functional studies of Avt1, a novel peptide from the sea anemone Aulactinia veratra [0.03%]
来源于海葵Aulactinia veratra的新肽Avt1的结构和功能研究
Renad A Albar,Hayden L Smith,Karoline Sanches et al.
Renad A Albar et al.
Sea anemones are a rich source of peptide toxins spanning a diverse range of biological activities, typically targeting proteins such as ion channels, receptors and transporters. These peptide toxins and their analogues are usually highly s...
Identification of dystrophin Dp71dΔ71-associated proteins in PC12 cells by quantitative proteomics [0.03%]
定量蛋白质组学鉴定PC12细胞中与Dp71dΔ71相关的蛋白
Coztli Azotla-Vilchis,Candelaria Merino-Jiménez,Emmanuel Ríos-Castro et al.
Coztli Azotla-Vilchis et al.
Dystrophin Dp71 is essential for the development of the nervous system. Its alteration is associated with intellectual disability. Different Dp71 isoforms are generated by alternative splicing; however, their functions have not been fully d...
Assembly of Hydrophobin class I from Agaricus bisporus produced different amyloid-like fibrils [0.03%]
来自双孢蘑菇的I类水合子装配产生不同类型的淀粉样纤维体
Jesús Rojas-Osnaya,Hugo Nájera
Jesús Rojas-Osnaya
This work studied the extraction, purification, characterization, and assembly of hydrophobin class I from Agaricus bisporus (ABH4). The highest soluble protein concentration was obtained from the pinhead, the extraction and purification we...
Serratiopeptidase exhibits antibiofilm activity through the proteolytic function of N-terminal domain and versatile function of the C-terminal domain [0.03%]
枯草杆菌肽通过N端结构域的蛋白水解功能和C端结构域的多种功能展现抗生物膜活性
Vishal Srivastava,Sheetal Bandhu,Shivam Mishra et al.
Vishal Srivastava et al.
Background: Serratiopeptidase, a serine protease traditionally used as an oral anti-inflammatory drug has been found to show antibiofilm action. Structurally, it comprises of two distinct domains; viz-the N-terminal catal...
From sequence to function: Exploring biophysical properties of bacteriophage BFK20 lytic transglycosylase domain from the minor tail protein gp15 [0.03%]
从序列到功能：研究噬菌体BFK20次要尾部蛋白gp15裂解转糖基酶结构域的生物物理性质
Kristina Papayova,Lucia Bocanova,Vladena Bauerova et al.
Kristina Papayova et al.
Bacteriophages have evolved different mechanisms of infection and penetration of bacterial cell walls. In Siphoviridae-like viruses, the inner tail proteins have a pivotal role in these processes and often encode lytic protein domains which...
Assigning roles in Chlamydomonas ribosome biogenesis: The conserved factor NIP7 [0.03%]
绿藻叶绿体中的核糖体生物发生：保守因子NIP7的作用机制研究
Raissa Ferreira Gutierrez,Heloisa Ciol,Angélica L Carrillo Barra et al.
Raissa Ferreira Gutierrez et al.
Ribosome biogenesis (RB) is a highly conserved process across eukaryotes that results in the assembly of functional ribosomal subunits. Studies in Saccharomyces cerevisiae and Homo sapiens have identified numerous RB factors (RBFs), includi...
Identification of potential pharmacological chaperones that selectively stabilize mutated Aspartoacylases in Canavan disease [0.03%]
卡那万病潜在药物伴侣的鉴定及其选择性稳定突变天冬氨酰胺酶的作用
Nitesh Kumar Poddar,Yasanandana S Wijayasinghe,Ronald E Viola
Nitesh Kumar Poddar
Canavan disease is caused by mutations in the ASPA gene, leading to diminished catalytic activity of aspartoacylase in the brain. Clinical missense mutations are found throughout the enzyme structure, with many of these mutated enzymes havi...
Kinetic characterization of the C-terminal domain of Malonyl-CoA reductase [0.03%]
丙二酰辅酶A还原酶C末端结构域的动态特征研究
Mirela Tkalcic Cavuzic,Amanda Silva de Sousa,Jeremy R Lohman et al.
Mirela Tkalcic Cavuzic et al.
Malonyl-CoA reductase utilizes two equivalents of NADPH to catalyze the reduction of malonyl-CoA to 3-hydroxypropionic acid (3HP). This reaction is part of the carbon fixation pathway in the phototrophic bacterium Chloroflexus aurantiacus. ...