Role of electrostatics in cold adaptation: A comparative study of eury- and stenopsychrophilic triose phosphate isomerase [0.03%]
静电作用在冷适应中的作用：全耐寒性和窄耐寒性甘油磷酸激酶的比较研究
Jan S Nowak,Sune Olesen,Pengfei Tian et al.
Jan S Nowak et al.
Psychrophilic (cold-active) organisms have developed enzymes that facilitate sufficient metabolic activity at low temperatures to sustain life. This occurs through molecular adaptations that tend to increase protein flexibility at the expen...
Exploring human carboxylesterases 1 and 2 selectivity of two families of substrates at an atomistic level [0.03%]
从原子水平上探讨人类羧酸酯酶1和2两类底物的选择性
Sergio R Ribone,Dario A Estrin,Mario A Quevedo
Sergio R Ribone
Human carboxylesterases (CES) are enzymes that play an important role in the metabolism and biotransformation of diverse substances. The two more relevant isoforms, CES1A1 and CES2A1, catalyze the hydrolysis of numerous approved drugs and p...
TMB Stab-pred: Predicting the stability of transmembrane β-barrel proteins using their sequence and structural signatures [0.03%]
基于序列和结构特征预测跨膜β barrels蛋白的稳定性
P Ramakrishna Reddy,A Kulandaisamy,M Michael Gromiha
P Ramakrishna Reddy
Understanding the folding and stability of transmembrane β-barrel proteins (TMBs) provides insights into their structural integrity, functional mechanisms, and implications for disease states. In this work, we have characterized the import...
Green tea polyphenol EGCG acts differentially on end-stage amyloid polymorphs of α-synuclein formed in different polyol osmolytes [0.03%]
绿色茶叶多酚EGCG对在不同多元醇渗透剂中形成的α-突触核蛋白终末期淀粉样聚集体的作用存在差异
Santosh Devi,Dushyant K Garg,Rajiv Bhat
Santosh Devi
Synucleinopathies are heterogenous group of disorders characterized by α-synuclein amyloid aggregates in the nervous system. Different synucleinopathy clinical subtypes are encoded by structurally diverse α-synuclein amyloid polymorphs re...
Crystal structure of thymidine kinase from the multi-drug resistant col strain of Staphylococcus aureus [0.03%]
多重耐药的社区 acquired MRSA菌株的脱氧胸苷激酶的晶体结构
Anam Ashraf,Ravi Kant Pal,Md Imtaiyaz Hassan
Anam Ashraf
Thymidine kinase (TK) is a key enzyme in the salvage pathway of thymidine that produces thymidine monophosphate. TK enzyme activity is tightly coupled to the cell cycle, exhibiting marked fluctuations in expression and activity. We report t...
Synovial fluid glycoproteome profiling in knee osteoarthritis: Molecular insights into type 2 diabetes-associated biomarkers and therapeutic targets [0.03%]
膝骨关节炎的滑液糖蛋白组分析：2型糖尿病相关生物标志物和治疗靶点的分子机制研究
Monidipa Konar,Bhavneet Kaur,Uttam Chand Saini et al.
Monidipa Konar et al.
Type 2 diabetes mellitus (T2DM) and osteoarthritis (OA) share common risk factors like age, obesity and hypertension. Currently, 52 % of diabetic patients suffer from arthritis. Diabetes facilitates osteoarthritis by altering lipid metaboli...
Efficient production of a novel recombinant fusion protein of EIEC effector IpaD and EGFP: Biophysical characterization and functional studies [0.03%]
产志贺毒素大肠杆菌效应蛋白IpaD与增强型绿色荧光蛋白融合表达的生物物理特性及功能研究
Sudeshna Halder,Namita Jaiswal,Salari Charan Balajee et al.
Sudeshna Halder et al.
The conserved invasion plasmid antigen D (IpaD) protein demonstrates broad protective capabilities against bacillary dysentery caused by Enteroinvasive Escherichia coli (EIEC) and Shigella. However, the instability of the IpaD protein at ro...
A Bartkowiak,Ewa Szczesny-Malysiak,Jakub Dybas
A Bartkowiak
Heme proteins are a large group of biomolecules with heme incorporated as a prosthetic group. Apart from cytochromes present in almost all cell types, many other specific heme proteins are expressed in different kinds of cells, e.g. hemoglo...
DSP-1, the major fibronectin type-II protein of donkey seminal plasma is a small heat-shock protein and exhibits chaperone-like activity against thermal and oxidative stress [0.03%]
DSP-1是公驴精液中主要的纤维连接蛋白II型蛋白，是一种小热休克蛋白，并对热和氧化应激表现出分子伴侣活性。
Sk Alim,Sudheer K Cheppali,Sonali S Pawar et al.
Sk Alim et al.
Fibronectin type-II (FnII) proteins are major constituents in the seminal plasma of many mammals and play a crucial role in sperm capacitation. Additionally, the seminal FnII proteins from bull and horse exhibit chaperone-like activity (CLA...
Participation of a cysteine tetrad in the recycling mechanism of methionine sulfoxide reductase a from radiation-tolerant Deinococcus bacteria [0.03%]
参与放线菌素耐受性德尼伯克氏菌甲硫氨酸硫酸盐还原酶A的循环机制中的半胱氨酸四联体的作用
Pascal Rey,Nicolas Rouhier,Chloé Carassus et al.
Pascal Rey et al.
Methionine oxidation leads to the formation of methionine sulfoxide (MetO), which is reduced back to Met by methionine sulfoxide reductases (Msrs). The catalytic mechanism used by A-type Msr (MsrA) for MetO reduction requires a catalytic cy...