Ishadi K M Kodikara,Valentine O Nwanelo,Angela K Belanger et al.
Ishadi K M Kodikara et al.
HDAC7 (histone deacetylase 7) is involved in many diseases, including breast cancer. HDAC7 regulates gene expression epigenetically by assisting in the deacetylation of nucleosomal histones to remodel chromatin. However, HDAC7 is a pseudode...
Victor G Chrone,Johan C Jespersen,Daut C Asani et al.
Victor G Chrone et al.
Immunoglobulin G (IgG) is fundamental to adaptive immunity and numerous monoclonal IgGs (monoclonal antibodies (MAbs)) have been developed as therapeutics for various diseases, including ocrelizumab (OMAb), a CD20 MAb used for treating mult...
Oxygen-carrying proteins employed in blood substitute candidates: differences in interactions with a model antioxidant molecule [0.03%]
氧载体蛋白在血液替代品中的应用：与一种模型抗氧化剂分子相互作用的差异
Maria Lehene,Jozsef Simon,Cezara Zagrean-Tuza et al.
Maria Lehene et al.
Glutaraldehyde-polymerized hemoglobin (poly-Hb) has long been explored as a key candidate for blood substitute compositions, to be used in transfusions in order to supplement the oxygen-carrying capacity following severe blood loss. Bovine ...
Crystal structure and molecular dynamics simulation of Mycobacterium tuberculosis MaoC-like dehydratase HtdX provide insights into substrate binding and membrane interactions [0.03%]
结核分枝杆菌MaoC样去水化酶HtdX的晶体结构和分子动力学模拟提供了底物结合及膜相互作用的新见解
Rupam Biswas,Gourab Bhattacharje,Bina Kumari Singh et al.
Rupam Biswas et al.
The growing challenge of drug resistance has intensified the search for new therapeutic targets against the virulent pathogen Mycobacterium tuberculosis (Mtb). The complex cell envelope of Mtb contains unique lipids, such as mycolic acids, ...
Unravelling the phosphoregulatory network of protein kinase C-delta (PKC-δ) [0.03%]
蛋白激酶Cdelta的磷酸调节网络研究
Darshan Hebbal Raghu,Leona Dcunha,Mukhtar Ahmed et al.
Darshan Hebbal Raghu et al.
Protein kinase C Delta (PRKCD) is a serine/threonine kinase involved in transcription regulation, cytoskeleton organization, DNA damage response, DNA repair and carcinogenesis. Several PRKCD phosphopeptides are frequently detected to be dif...
Elucidation of multifunctionality and substrate specificity of human aspartate aminotransferases [0.03%]
人类天冬氨酸转氨酶多功能性和底物特异性的阐明
Tetsuya Miyamoto,Haruna Kito,Karen Sato et al.
Tetsuya Miyamoto et al.
d-Serine and d-aspartate play crucial physiological roles in mammals. d-Serine is produced by serine racemase, but the biosynthetic pathway of d-aspartate remains unclear. In this study, we investigated the substrate specificity and multifu...
Computing pathogenicity of mutations in human cytochrome P450 superfamily [0.03%]
计算人类细胞色素P450超家族突变致病性的方法
Somnath Mondal,Pranchal Shrivastava,Rukmankesh Mehra
Somnath Mondal
Cytochrome P450 (CYPs) are crucial heme-containing enzymes that metabolize drugs and endogenous compounds. In humans, 57 CYP isoforms have been identified, with over 200 mutations linked to severe disorders. Our comprehensive computational ...
Parishin C modulates the amyloid transformation of alpha-synuclein protein by apparently interacting with the NAC domain [0.03%]
parishin C通过与NAC结构域相互作用来调节α-突触核蛋白的淀粉样转化
Almas Akhtar,Payal Singh,Nikita Admane et al.
Almas Akhtar et al.
Parkinson's disease (PD) is a neurodegenerative disorder marked by the gradual deterioration of dopaminergic neurons in the brain and the presence of Lewy bodies (LB) within the remaining affected neurons, comprised of α-synuclein protein ...
Biophysical analysis of SECIS binding protein 2 (SBP2) from Naegleria gruberi [0.03%]
纳格利雅原虫SECIS结合蛋白2(SBP2)的生物物理分析
Jéssica Fernandes Scortecci,Adriano de Freitas Fernandes,Vitor Hugo Balasco Serrão et al.
Jéssica Fernandes Scortecci et al.
The Selenocysteine (Sec - U) biosynthesis pathway is present in eukaryotes and prokaryotes, in which its incorporation is directed by the stop codon UGA and the structural mRNA element named Sec Insertion Sequence (SECIS) that contain an es...
Structural, functional relevance of DNAJBs in protein aggregation and associated neurodegenerative diseases [0.03%]
DNAJ家族成员在蛋白质聚集及其相关神经退行性疾病中的结构和功能作用
Siraj Fatima,Priyanka Pandey,Sandeep K Sharma et al.
Siraj Fatima et al.
DNAJ proteins, also known as HSP40s, are co-chaperones that regulate the multifunctionality of HSP70s in maintaining cellular protein homeostasis. The heterogeneous family of DNAJ co-chaperones is classified into three classes (A, B and C),...