AttnSeq-PPI: Enhancing protein-protein interaction network prediction using transfer learning-driven hybrid attention [0.03%]
基于迁移学习的混合注意力增强蛋白质相互作用网络预测模型
Dipayan Sarkar,Chiranjib Sarkar
Dipayan Sarkar
Study of protein-protein interaction (PPI) network is fundamental to all cellular processes in living organisms. PPI study based on experimental techniques such as high-throughput assays, mass spectrometry is time-consuming and expensive. C...
Structure and analysis of a virulent chitinase from Listeria monocytogenes [0.03%]
单核细胞增生性李斯特菌致病性几丁质酶的结构与分析
Saima Rehman,Maria Baczynska,Beichang Zhang et al.
Saima Rehman et al.
Listeria monocytogenes is the causative agent of Listeriosis, a serious foodborne illness that primarily affects pregnant women, new-borns, the elderly, and immunocompromised individuals. L. monocytogenes secretes proteins that bind and deg...
Deciphering the structural attributes of PPAR-γ and SIRT1 to identify their dual activators using a combined molecular modeling approach [0.03%]
基于分子模拟的结合口袋特征研究及双激动剂设计与筛选
Swati Dogra,Arijit Bhattacharya,Gera Narendra et al.
Swati Dogra et al.
PPAR-γ and SIRT1 are the emerging targets that are vital in diabetes and diabetic complications. So, the development of dual activators for PPAR-γ and SIRT1 can be a good strategy in the treatment of diabetes and diabetic complications an...
Direct cryo-EM visualization of the β-sheet structure in curved amyloid protofibril [0.03%]
直接cryo-EM观测弯曲淀粉样原纤维中的β折叠结构
Naoki Yamamoto,Jin Inoue,Ritsumi Saito et al.
Naoki Yamamoto et al.
Protofibrils are key intermediates to explore effective therapeutic strategies for amyloid-related diseases; however, their structural features remain largely ambiguous. Here, we report a direct visualization of the intermolecular β-sheet ...
Insights into key kinase regulatory network of LARP1 based on co-occurring phosphorylation events [0.03%]
基于协同磷酸化事件的LARP1关键激酶调控网络研究
Ashika Bangera,Nazah Naurah,Samseera Ummar et al.
Ashika Bangera et al.
LARP1 (La-related protein 1) is an important mediator of translation regulation that stabilizes terminal oligopyrimidine motif-containing mRNAs. LARP1, being a direct target of mechanistic Target of Rapamycin Complex 1 (mTORC1), undergoes p...
Phafin2 modulates the aggregation of NLRP3 on dispersed trans-Golgi network [0.03%]
Phafin2调控分散的反式高尔基网络上NLRP3的聚集现象
Yurou Li,Kaiyong Zheng,Chunsheng Chen et al.
Yurou Li et al.
NLRP3 is one of the central players in innate immune signaling. Upon stimulation, NLRP3 could oligomerize and recruit ASC, NEK7, and caspase 1 (CASP1), then assemble into inflammasome, triggering downstream inflammation and pyroptosis. Rece...
Understanding Huntington protein aggregation in cell mimicking environments [0.03%]
类细胞模拟环境中的亨廷顿蛋白聚集的初步研究
Apurva Mishra,Pramit K Chowdhury
Apurva Mishra
Protein aggregation plays a crucial role in various neurodegenerative diseases, including Huntington's disease. Understanding the factors influencing aggregation kinetics is essential for deciphering disease mechanisms. This research paper ...
Lin Qi,Mark Isalan
Lin Qi
De novo proteins represent a challenging frontier at the intersection of evolutionary biology and synthetic biology. Broadly, the term encompasses two distinct categories: naturally evolved de novo proteins, which arise from previously non-...
Characterization of fatty acid biosynthesis in microalga Scenedesmus - from the perspective of biofuel production [0.03%]
从生物燃料生产角度表征微藻Scenedesmus中脂肪酸的合成特征
Harshit Kumar Sharma,Ma Belén Velázquez,Noelia Marchetti et al.
Harshit Kumar Sharma et al.
Scenedesmus quadricauda, a freshwater microalga, has gained attention for its high lipid accumulation potential. However, information on fatty acid (FA) biosynthesis pathways in Scenedesmus species remains limited. Biomass (1.010 gL-1) and ...
Solution-based studies on the contact between the complement receptor 3 ligand-binding domain and simvastatin [0.03%]
基于溶液的研究：补体受体3配体结合域与辛伐他汀的相互作用
Morten Hulbæk Fog,Violaine Hubert,Corinne Sanglar et al.
Morten Hulbæk Fog et al.
Simvastatin is a primary cholesterol-lowering medication, but it has also been reported to possess anti-inflammatory properties. Notably, the CD18 integrins are targets for simvastatin antagonism of ligand binding, which may affect leukocyt...