Identification of the interfacial regions in misfolded transthyretin oligomers [0.03%]
鉴定误折叠的甲状腺转运蛋白低聚物的界面区域
Anvesh K R Dasari,Matthew F Coats,Abdullah B Ali et al.
Anvesh K R Dasari et al.
Misfolding and aggregation of transthyretin (TTR) is associated with numerous ATTR amyloidosis. TTR aggregates extracted from ATTR patients consist of not only full-length TTR, but also N-terminally truncated TTR fragments that can be produ...
Assessing the Martini 3 protein model: A review of its path and potential [0.03%]
评估Martini 3蛋白模型：回顾其路径和潜力
Luís Borges-Araújo,Gilberto P Pereira,Mariana Valério et al.
Luís Borges-Araújo et al.
Coarse-grained (CG) protein models have become indispensable tools for studying many biological protein details, from conformational dynamics to the organization of protein macro-complexes, and even the interaction of proteins with other mo...
The molecular interplay between human and bacterial amyloids: Implications in neurodegenerative diseases [0.03%]
人和细菌淀粉样蛋白之间的分子相互作用：在神经退行性疾病中的影响
Neha Jain
Neha Jain
Neurodegenerative disorders such as Parkinson's (PD) and Alzheimer's diseases (AD) are linked with the assembly and accumulation of proteins into structured scaffold called amyloids. These diseases pose significant challenges due to their c...
Chemical proteomics approaches for protein post-translational modification studies [0.03%]
化学蛋白质组学方法用于蛋白质翻译后修饰研究
Nan Zhang,Jinghua Wu,Qingfei Zheng
Nan Zhang
The diversity and dynamics of proteins play essential roles in maintaining the basic constructions and functions of cells. The abundance of functional proteins is regulated by the transcription and translation processes, while the alternati...
Conformational and dynamic properties of the KH1 domain of FMRP and its fragile X syndrome linked G266E variant [0.03%]
脆性X综合征KH1结构域及其G266E突变体的构象与动态性质研究
Flavia Catalano,Daniele Santorelli,Alessandra Astegno et al.
Flavia Catalano et al.
The Fragile X messenger ribonucleoprotein (FMRP) is a multi-domain protein involved in interactions with various macromolecules, including proteins and coding/non-coding RNAs. The three KH domains (KH0, KH1 and KH2) within FMRP are recogniz...
The apo-acyl coenzyme A binding protein of Leishmania major forms a unique 'AXXA' motif mediated dimer [0.03%]
利什曼原虫的游离酰基辅酶a结合蛋白形成一个独特的由"AXXA"基序介导的二聚体
Shalini Verma,Rohit Singh Dangi,Manoj Kumar Rajak et al.
Shalini Verma et al.
Acyl-Coenzyme A binding domain containing proteins (ACBDs) are ubiquitous in nearly all eukaryotes. They can exist as a free protein, or a domain of a large, multidomain, multifunctional protein. Besides modularity, ACBDs also display multi...
Characterization of AICAR transformylase/IMP cyclohydrolase (ATIC) bifunctional enzyme from Candidatus Liberibacer asiaticus [0.03%]
稻粒肿原体AICA转酰基酶/次黄嘌呤-鸟嘌呤核苷酸磷酸核糖转移酶(ATIC)双功能酶的鉴定
Sapna Lonare,Surabhi Rode,Preeti Verma et al.
Sapna Lonare et al.
The bifunctional enzyme, 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR) transformylase/inosine monophosphate (IMP) cyclohydrolase (ATIC) is involved in catalyzing penultimate and final steps of purine de novo biosynthetic pathway cru...
A role of methionines in the functioning of oxidatively modified fibrinogen [0.03%]
甲硫氨酸在氧化修饰纤维蛋白原功能中的作用
L V Yurina,A D Vasilyeva,E S Gavrilina et al.
L V Yurina et al.
Posttranslational modifications in fibrinogen resulting from induced oxidation or oxidative stress in the organism can have deleterious influence on optimal functioning of fibrinogen, causing a disturbance in assembly and properties of fibr...
Epitope mapping of SARS-CoV-2 RBDs by hydroxyl radical protein footprinting reveals the importance of including negative antibody controls [0.03%]
SARS-CoV-2 RBD表位图谱的羟基 radicals 蛋白质足迹法测定：包含阴性抗体对照的重要性不容忽视
Daniel Nyberg Larsen,Jakub Zbigniew Kaczmarek,Yaseelan Palarasah et al.
Daniel Nyberg Larsen et al.
Understanding protein-protein interactions is crucial for drug design and investigating biological processes. Various techniques, such as CryoEM, X-ray spectroscopy, linear epitope mapping, and mass spectrometry-based methods, can be employ...
Active roles of lytic polysaccharide monooxygenases in human pathogenicity [0.03%]
溶解性多糖单加氧酶在人类病原体中的积极作用
Daniel Kracher,Tina Lanzmaier,Leonor Vieira Carneiro
Daniel Kracher
Lytic polysaccharide monooxygenases (LPMOs) are redox enzymes widely studied for their involvement in microbial and fungal biomass degradation. The catalytic versatility of these enzymes is demonstrated by the recent discovery of LPMOs in a...