Mesenchymal stromal cell extracellular vesicles as immune modulators and drug carriers in neurodegenerative disorders [0.03%]
间充质基质细胞外泌体在神经退行性疾病中作为免疫调节剂和药物载体的作用
Lien Van Hoecke,Cristiano Lucci,Roosmarijn E Vandenbroucke
Lien Van Hoecke
Mesenchymal stromal cells (MSCs) hold significant therapeutic potential, but their clinical application is often hindered by limitations such as donor variability. MSC-derived extracellular vesicles (EVs) present a promising alternative, of...
Adrian J Duszkiewicz,Desdemona Fricker,Andrea Burgalossi et al.
Adrian J Duszkiewicz et al.
The organisation of thalamocortical networks follows a conserved structure. Traditionally, these are divided into primary sensory systems that receive subcortical sensory signals, and higher-order systems that are driven predominantly by co...
Modulation of viral neuroinflammation by astrocytic RIPK3 and serine protease inhibitors [0.03%]
通过星形胶质细胞RIPK3和丝氨酸蛋白酶抑制剂调节病毒神经炎症反应
Ebba Rosendal,Anna K Överby
Ebba Rosendal
A recent study by Lindman and colleagues highlights a cell type-specific function of receptor-interacting kinase 3 (RIPK3) in astrocytes during neurotropic flavivirus infection. Despite a proinflammatory transcriptional profile, RIPK3 in as...
Laura L Grima,Hannah Haberkern,Rishika Mohanta et al.
Laura L Grima et al.
The study of foraging is central to a renewed interest in naturalistic behavior in neuroscience. Applying a foraging framework grounded in behavioral ecology has enabled probing of the mechanisms underlying cognitive processes such as decis...
Pablo Barttfeld,Nicolás Comay,Iair Embon et al.
Pablo Barttfeld et al.
In a recent study, Goueytes and colleagues combined computational modeling with intracranial recordings to dissect the neural basis of confidence and changes of mind. They reveal a temporally organized, spatially distributed hierarchy of ev...
How prediction error drives memory updating: role of locus coeruleus-hippocampal interactions [0.03%]
预测误差驱动记忆更新的作用：蓝斑-海马相互作用的影响
Isabelle Groves,Stephanie L Grella,Carolyn W Harley et al.
Isabelle Groves et al.
The brain constantly generates predictions based on one's knowledge of the world, as captured in memory. When these predictions are in error, our knowledge base must be revised to remain relevant. Here, we propose that this error-driven upd...
Zhihao Zhang,Yanxia Chen,Qian Yu et al.
Zhihao Zhang et al.
Growing evidence documents that the influence of sedentary behaviors on brain health is not universally beneficial or detrimental but rather context-dependent and nuanced. More specifically, recent findings suggest that mentally active sede...
José R Sotelo-Silveira
José R Sotelo-Silveira
In a recent publication, Broix, Roy, and colleagues have shown that m6A controls local translation of the RNA-binding protein APC via YTHDF1, coupling RNA modification to β-actin mRNA local translation and axon growth. In addition, autism-...
Harnessing neuronal plasticity for sustained symptom relief with DBS [0.03%]
利用深部脑刺激(DBS)的神经可塑性实现持续的症状缓解
Doris D Wang,Coralie de Hemptinne
Doris D Wang
In a recent study, Spencer and colleagues demonstrated that high-frequency microsimulation of the globus pallidus internus (GPi) in individuals with Parkinson's disease induces long-term potentiation (LTP)-like effects in the inhibitory pat...
How do ramping dynamics influence computations in the entorhinal cortex? [0.03%]
放电速率的动态变化对内侧颞叶皮层计算过程的影响是什么？
Matthew F Nolan
Matthew F Nolan
The entorhinal cortex is crucial for declarative memory and spatial cognition. Recent experiments reveal that many entorhinal neurons represent information through ramping activity in which their firing rate changes monotonically between be...