Alexander Fröhlich,Kathryn R Bowles
Alexander Fröhlich
Tau phosphorylation plays an essential role in regulating tau's microtubule-stabilizing function, but its hyperphosphorylation drives tauopathies such as Alzheimer's disease (AD). In a recent study, Kim and colleagues decipher that tyrosine...
Margaret M Henderson,Michael J Tarr,Leila Wehbe
Margaret M Henderson
Several recent studies, enabled by advances in neuroimaging methods and large-scale datasets, have identified areas in human ventral visual cortex that respond more strongly to food images than to images of many other categories, adding to ...
Re-examining the pathobiological basis of gait dysfunction in Parkinson's disease [0.03%]
帕金森病步态障碍的病理生理基础再探讨
Newton Cho,Lorraine V Kalia,Suneil K Kalia
Newton Cho
Parkinson's disease (PD) is a significant source of morbidity, especially with an aging population. Gait problems, particularly freezing of gait (FOG), remain a persistent issue, causing falls and reduced quality of life without consistent ...
Akiko Terauchi,Erin M Johnson-Venkatesh,Hisashi Umemori
Akiko Terauchi
Despite accounting for only ~0.001% of all neurons in the human brain, midbrain dopaminergic neurons control numerous behaviors and are associated with many neuropsychiatric disorders that affect our physical and mental health. Dopaminergic...
Making sense of vertebrate senses from a neural crest and cranial placode evo-devo perspective [0.03%]
从神经脊和颅节瘤的进化与发育角度理解脊椎动物的感觉系统
Brittany M Edens,Marianne E Bronner
Brittany M Edens
The evolution of vertebrates from protochordate ancestors marked the beginning of the gradual transition to predatory lifestyles. Enabled by the acquisition of multipotent neural crest and cranial placode cell populations, vertebrates devel...
Hannah Shoenhard,Amita Sehgal
Hannah Shoenhard
Memory consolidation requires rapid energy supply to neurons. In a recent study, Francés et al. revealed the signal by which a neuron commands glia to limit fatty acid synthesis in favor of metabolite export during memory formation in Dros...
Na Xu,Si-Yu Chen,Ai-Hui Tang
Na Xu
The precise organization of the complex set of synaptic proteins at the nanometer scale is crucial for synaptic transmission. At the heart of this nanoscale architecture lies the nanocolumn. This aligns presynaptic neurotransmitter release ...
Elucidating hemodynamics and neuro-glio-vascular signaling using rodent fMRI [0.03%]
利用小鼠fMRI阐明血流动力学及神经-胶质-血管信号通路
Xiaoqing Alice Zhou,Yuanyuan Jiang,Lidia Gomez-Cid et al.
Xiaoqing Alice Zhou et al.
Despite extensive functional mapping studies using rodent functional magnetic resonance imaging (fMRI), interpreting the fMRI signals in relation to their neuronal origins remains challenging due to the hemodynamic nature of the response. U...
Jonas Obleser
Jonas Obleser
How do you know you have heard right? Metacognition, the ability to assess and monitor one's own cognitive state, is key to understanding human communication in complex environments. However, the foundational role of metacognition in hearin...
Mechanistic insights into chemotherapy-induced circadian disruption using rodent models [0.03%]
利用啮齿动物模型探讨化疗诱导的昼夜节律紊乱的机制
Zoe M Tapp,Amiya K Ghosh,Karl H Obrietan et al.
Zoe M Tapp et al.
Chemotherapy treatment can significantly increase the survival of patients with cancer, but it also causes collateral damage in the body that can lead to treatment dose reductions and can reduce patient quality of life. One understudied sid...