Atomic insights into the physiological and functional diversity of NMDA receptors [0.03%]
原子分辨率N-甲基-D-天冬氨酸受体生理学和功能多样性的见解
Ke Xu,Siming Wu,Shujia Zhu
Ke Xu
N-methyl-D-aspartate receptors (NMDARs) are essential for brain development, memory processes, and cognition. They primarily act as coincidence detectors at the synapse, integrating presynaptic glutamate release and postsynaptic membrane de...
Kyle O&#x;Berry,Aryn H Gittis
Kyle O&#x;Berry
The globus pallidus externus (GPe) is a central nucleus in the basal ganglia. Although traditionally defined as a component of the basal ganglia's motor circuit, converging evidence from humans, rodents, and non-human primates has establish...
Re-examining the structure-function relationship in tactile corpuscles [0.03%]
重新审视触觉 corpuscle 的结构功能关系
Alan J Emanuel
Alan J Emanuel
In a recent study, Chikamoto and colleagues challenged the view that velocity tuning of axons associated with Pacinian corpuscles arises from interactions between the axon terminal and the surrounding lamellar cells. Instead, their investig...
The 'neat' and 'messy' in task-dependent neural geometry and computation [0.03%]
任务依赖的神经几何和计算中的“整洁”与“杂乱”现象
Cheng Xue,Gouki Okazawa
Cheng Xue
To solve diverse real-world tasks, the brain must flexibly switch between task rules and adjust computations. Recent advances in analyzing neural data and modeling neural networks have revealed their 'neat' features: neuronal population act...
Venous origins of choroid plexus vasculature: insights from zebrafish [0.03%]
源自静脉的脉络丛血管的发生过程：来自斑马鱼研究的新见解
Bing Xu,Yu Zhang,Wen-Jie Du et al.
Bing Xu et al.
The choroid plexus vasculature plays a critical role in maintaining cerebrospinal fluid homeostasis. In a recent study, Lee et al. identified two venous sources that give rise to the hindbrain myelencephalic choroid plexus vasculature in ze...
Yidan Ding,Joshua Kosnoff,Bin He
Yidan Ding
Brain-computer interfaces (BCIs) decode neural activity to enable direct communication with external devices. This process consists of three modules: signal acquisition, signal processing, and output translation. While invasive BCIs have de...
Third spaces for science: reimagining research beyond academia and industry [0.03%]
超越学术界和产业界的科学第三空间：重塑研究形象
Meike Ramon,Bigna Lenggenhager,Marte Roel Lesur et al.
Meike Ramon et al.
Science is a public good, yet the spaces where it is produced remain structurally constrained. Independent researchers, citizen scientists, and practitioners often lack access to institutional conditions needed for scientific work that is s...
Na N Guan,Jianren Song
Na N Guan
In a recent study, Slangewal et al. explored principles of visuomotor decision-making in larval zebrafish. Visuomotor choices were revealed to be largely additive, integrating visual motion, luminance level, and luminance change during cue ...
Dong Dong,Longzhen Cheng
Dong Dong
How does brushing one's hair become agony? In a recent study, Li, Son, and colleagues genetically isolated the specific trigeminal afferents that transduce touch into pain after nerve injury, revealing a critical role for Piezo2 in driving ...
Epigenetic noise in the aging brain: tuning neuronal vulnerability to neurodegeneration [0.03%]
衰老大脑中的表观遗传噪音：调节神经元对神经退行性病变的易感性
Xinyang Yin,Houchun Zhang,Ru Zhang et al.
Xinyang Yin et al.
Aging is the predominant risk factor for neurodegenerative diseases, yet the mechanisms linking biological aging to selective neuronal degeneration remain incompletely understood. Accumulating evidence indicates that aging progressively dis...