Evolving perspectives on the molecular and neural foundations of mammalian circadian rhythms [0.03%]
不断发展的关于哺乳动物昼夜节律的分子和神经基础的观点
Yanqin Liu,Ran Huo,Eric E Zhang
Yanqin Liu
Circadian regulation is multilayered and hierarchical, enabling organisms to anticipate and adapt to daily environmental changes driven by the Earth's rotation. The classical transcriptional-translational feedback loop (TTFL) remains a foun...
Interacting corticobasal ganglia-thalamocortical loops shape behavioral control through cognitive maps and shortcuts [0.03%]
皮质基底节-丘脑回路通过认知地图和捷径塑造行为控制
Fred H Hamker,Javier Baladron,Lieneke K Janssen
Fred H Hamker
Control of behavior is often explained in terms of a dichotomy, with distinct neural circuits underlying goal-directed and habitual control, yet accumulating evidence suggests these processes are deeply intertwined. We propose a novel anato...
Mesenchymal stromal cell extracellular vesicles as immune modulators and drug carriers in neurodegenerative disorders [0.03%]
间充质基质细胞外泌体在神经退行性疾病中作为免疫调节剂和药物载体的作用
Lien Van Hoecke,Cristiano Lucci,Roosmarijn E Vandenbroucke
Lien Van Hoecke
Mesenchymal stromal cells (MSCs) hold significant therapeutic potential, but their clinical application is often hindered by limitations such as donor variability. MSC-derived extracellular vesicles (EVs) present a promising alternative, of...
Adrian J Duszkiewicz,Desdemona Fricker,Andrea Burgalossi et al.
Adrian J Duszkiewicz et al.
The organisation of thalamocortical networks follows a conserved structure. Traditionally, these are divided into primary sensory systems that receive subcortical sensory signals, and higher-order systems that are driven predominantly by co...
Modulation of viral neuroinflammation by astrocytic RIPK3 and serine protease inhibitors [0.03%]
通过星形胶质细胞RIPK3和丝氨酸蛋白酶抑制剂调节病毒神经炎症反应
Ebba Rosendal,Anna K Överby
Ebba Rosendal
A recent study by Lindman and colleagues highlights a cell type-specific function of receptor-interacting kinase 3 (RIPK3) in astrocytes during neurotropic flavivirus infection. Despite a proinflammatory transcriptional profile, RIPK3 in as...
Laura L Grima,Hannah Haberkern,Rishika Mohanta et al.
Laura L Grima et al.
The study of foraging is central to a renewed interest in naturalistic behavior in neuroscience. Applying a foraging framework grounded in behavioral ecology has enabled probing of the mechanisms underlying cognitive processes such as decis...
Pablo Barttfeld,Nicolás Comay,Iair Embon et al.
Pablo Barttfeld et al.
In a recent study, Goueytes and colleagues combined computational modeling with intracranial recordings to dissect the neural basis of confidence and changes of mind. They reveal a temporally organized, spatially distributed hierarchy of ev...
How prediction error drives memory updating: role of locus coeruleus-hippocampal interactions [0.03%]
预测误差驱动记忆更新的作用:蓝斑-海马相互作用的影响
Isabelle Groves,Stephanie L Grella,Carolyn W Harley et al.
Isabelle Groves et al.
The brain constantly generates predictions based on one's knowledge of the world, as captured in memory. When these predictions are in error, our knowledge base must be revised to remain relevant. Here, we propose that this error-driven upd...
Zhihao Zhang,Yanxia Chen,Qian Yu et al.
Zhihao Zhang et al.
Growing evidence documents that the influence of sedentary behaviors on brain health is not universally beneficial or detrimental but rather context-dependent and nuanced. More specifically, recent findings suggest that mentally active sede...
José R Sotelo-Silveira
José R Sotelo-Silveira
In a recent publication, Broix, Roy, and colleagues have shown that m6A controls local translation of the RNA-binding protein APC via YTHDF1, coupling RNA modification to β-actin mRNA local translation and axon growth. In addition, autism-...