Lilian G Jerow,Darcy A Krueger,Christina Gross et al.
Lilian G Jerow et al.
Somatic mutations in genes regulating mechanistic target of rapamycin (mTOR) pathway signaling can cause epilepsy, autism, and cognitive dysfunction. Research has predominantly focused on mTOR regulation of excitatory neurons in these condi...
A role for respiration in coordinating sleep oscillations and memory consolidation [0.03%]
呼吸在睡眠振荡及记忆巩固中的作用
Fabian Schwimmbeck,Esteban Bullón Tarrasó,Thomas Schreiner
Fabian Schwimmbeck
Memory consolidation is thought to rely on the interplay of sleep-related brain oscillations. Drawing on recent findings that highlight the influence of respiration on these rhythms, we outline a framework positioning respiration as pacemak...
Matthijs A A van der Meer,Daniel Bendor
Matthijs A A van der Meer
Hippocampal replay is widely thought to support two key cognitive functions: online decision-making and offline memory consolidation. In this review, we take a closer look at the hypothesized link between awake replay and online decision-ma...
MicroRNA regulation of enteric nervous system development and disease [0.03%]
microRNA在肠神经系统发育及疾病中的调节作用
Amy Marie Holland,Reindert Jehoul,Jorunn Vranken et al.
Amy Marie Holland et al.
The enteric nervous system (ENS), an elaborate network of neurons and glia woven through the gastrointestinal tract, is integral for digestive physiology and broader human health. Commensurate with its importance, ENS dysfunction is linked ...
Adam P Swiercz,Mumeko C Tsuda,Heather A Cameron
Adam P Swiercz
Novel object recognition tasks are commonly used to assess memory in rodents. These tests rely on an innate preference for exploring objects that are new or have been moved or changed. However, this preference, while normally seen in contro...
Attenuating the neuronal response to chronic stress through transcription factor aggregation [0.03%]
通过转录因子聚合来减弱神经元对慢性压力的反应
Mathilde Solyga,Florence Besse
Mathilde Solyga
How do neurons cope with chronic stress? In a recent study using blind Drosophila models, Shekhar and colleagues uncovered that chronic sensory deprivation induces brain-wide accumulation of aggregates sequestering transcription factors of ...
Min Chen,Hailan Hu
Min Chen
Reward processing is a critical brain function. Zichó and colleagues recently identified a previously unrecognized brainstem nucleus, the subventricular tegmental nucleus (SVTg), as a novel reward center that modulates dopamine release and...
Peter Denno,Sijia Zhao,Masud Husain et al.
Peter Denno et al.
'Brain fog' is commonly reported in more than a dozen chronic diseases, but what is it? We review research across conditions which has characterised brain fog and evaluate its definitions and objective correlates. Brain fog has been used to...
Xavier J Maddern,Lauren T Ursich,Leigh C Walker
Xavier J Maddern
Sex hormones shape behavior through diverse mechanisms. In a recent study, Zallar et al. have uncovered a rapid, nongenomic estrogen signaling pathway mediating binge drinking in female mice via membrane-associated estrogen receptor α (ER...
Digestive exophagy as a novel mechanism of amyloid-β degradation by microglial lysosomes [0.03%]
微胶质细胞溶酶体通过消化型自噬降解淀粉样蛋白-β的一种新机制
Melanie Meyer-Luehmann
Melanie Meyer-Luehmann
Microglia are known to be involved in the modulation of amyloid-β (Aβ) plaques in Alzheimer's disease (AD). In a recent study, Jacquet et al. describe how microglia degrade larger Aβ aggregates by forming lysosomal synapses, further impl...