When viral infections rewire neural circuits: towards cognitive virology [0.03%]
当病毒感染重塑神经回路时：走向认知病毒学
Jules Bouget,Emma Partiot,Raphael Gaudin
Jules Bouget
Viral infections cause a wide range of neurocognitive disorders. However, the molecular mechanisms that give rise to acute and chronic cognitive deficits remain poorly understood. In this opinion article we review current knowledge on the c...
Sexual dimorphism in pheromone perception across worms, flies, and rodents [0.03%]
从线虫、果蝇到啮齿动物的性信息素感知性别二态性
Qian Li,Yufeng Pan,Xia-Jing Tong
Qian Li
Sex-specific chemosensory behaviors arise from differences in how males and females detect and process environmental chemical cues, including pheromones, which drive sex-appropriate behaviors essential for reproduction across many species. ...
Yufan Dong,Danqian Liu
Yufan Dong
Rapid eye movement (REM) sleep is a unique state classically defined by brain activation and muscle paralysis. It is now recognized as a dynamic process involving coordinated oscillations and phasic behaviors, with substantial variations ac...
Yu P Zhang,Shekhar Kedia,David Klenerman
Yu P Zhang
Neurodegenerative diseases have long been considered distinct proteinopathies: amyloid-β and tau in Alzheimer's disease, α-synuclein in Parkinson's disease, and TDP-43 in amyotrophic lateral sclerosis. This single-protein paradigm has gui...
Csaba Cserép,Péter Berki,Mayte Mars et al.
Csaba Cserép et al.
Microglia are resident immune cells of the central nervous system (CNS) that dynamically adapt to their microenvironment to achieve multiple housekeeping roles. While ex vivo and in vitro models are instrumental tools to study microglial fu...
Freek van Ede,Daniela Gresch,Anna C Nobre
Freek van Ede
Neural processing is often categorized as externally or internally focused. Though commonly treated as poles of a single dimension, we delineate how the terms 'external' and 'internal' refer to independent concepts at the levels of cognitiv...
Kenshiro Fujise,Jaya Mishra,Nasser Karmali et al.
Kenshiro Fujise et al.
Synapses are traditionally defined by the presence of presynaptic vesicle pools and postsynaptic densities. Dopaminergic neurons, however, frequently form bouton-like structures that lack these conventional postsynaptic specializations. Rec...
Zichen He,Jacob J Morra,Eva A Naumann
Zichen He
In a recent article, Légaré and colleagues demonstrate that key mammalian brain network organizational features, which have been extensively mapped in human functional connectivity studies, are conserved in the tiny vertebrate brain of th...
Evolving perspectives on the molecular and neural foundations of mammalian circadian rhythms [0.03%]
不断发展的关于哺乳动物昼夜节律的分子和神经基础的观点
Yanqin Liu,Ran Huo,Eric E Zhang
Yanqin Liu
Circadian regulation is multilayered and hierarchical, enabling organisms to anticipate and adapt to daily environmental changes driven by the Earth's rotation. The classical transcriptional-translational feedback loop (TTFL) remains a foun...
Interacting corticobasal ganglia-thalamocortical loops shape behavioral control through cognitive maps and shortcuts [0.03%]
皮质基底节-丘脑回路通过认知地图和捷径塑造行为控制
Fred H Hamker,Javier Baladron,Lieneke K Janssen
Fred H Hamker
Control of behavior is often explained in terms of a dichotomy, with distinct neural circuits underlying goal-directed and habitual control, yet accumulating evidence suggests these processes are deeply intertwined. We propose a novel anato...